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pharma > DMARDS > Flashcards

DMARDS Flashcards

1
Q

Methotrexate

A 
1sr line agent , rapid onset 
AE: 
nausea and mucosal ulcer 
leukopenia,anemia.stomatitis,GI ulceration , alopecia 
hepatotoxicity
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2
Q

methotraxate mechanism

A

١- ⬆️ AMP ➡️ adenosine (inhib inflam)

٢- folate antagonist : ❌ purine synth ➡️ affect lymphocyte and macrophage

⬇️ proliferation + ⬆️ apoptosis

⬇️ proinflam cyrokines

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3
Q

Leflunomide

A

Block pyrimidine synth ➡️ ⬇️ T cell prolif + production of autoantibodies by B cells

⬇️ TNF-a dependent

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4
Q

Sulfasalazine

A

synthetic drug ( aminosalicylic acid+ Sulfapyrdine)

suppression of T cell response + ⬇️ B cell prolif

⬇️ lymphocyte function

synergistic effect with metho or antimalaria(hydroxy chloroquin)

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5
Q

(hydroxy chloroquin)

A

antimalaria

AE : ocular toxicity

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pharma (4 decks)

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