DM & renal

Question 1

ACCORD trial

Answer 1

Intensive glucose control associated with increased mortality (targeting HbA1c <6.0% resulted in higher risk of cardiovascular and all-cause mortality as compared with standard therapy (i.e., targeting hba1c between 7.0-7.9%)

Question 2

ADVANCE trial

Answer 2

Intensive glycemic control reduces risk of nephropathy when compared to conventional glycemic control (≤ 180 mg/dL)

Question 3

NICE-SUGAR trial

Answer 3

Tight glycemic control (81-108 mg/dL) in critically ill patients is associated with higher mortality when compared to conventional glycemic control (≤ 180 mg/dL)

Question 4

DIGAMI trial

Answer 4

In diabetic patients with acute myocardial infarction, insulin-glucose infusion with subsequent long-term insulin treatment reduces mortality at 1 year

Question 5

CHOIR trial

Answer 5

Target lower hemoglobin levels in patients with anemia and chronic kidney disease

Question 6

MDRD trial

Answer 6

In patients with elevated baseline proteinuria (≥1 g/day in moderate insufficiency, ≥3 g/day in severe insufficiency), lower blood pressure targets significantly delayed the progression of renal disease