DLA8, DLA10- Skin Overview and Infections Flashcards
list the 5 layers of epidermis
(superficial to deep) -stratum corneum (-stratum lucidum, thick skin only) -stratum granulosum -stratum spinosum -stratum basale
list the natural defense mechanisms of the skin
- keratin
- AMPs (antimicrobial peptides) host defense
- skin sloughing
- Sebum: low pH, lipids (sphinoid bases)
- Sweat: low pH, high salt, lysozymes (peptidoglycan disruption)
(1) and (2) are common infections related to poor hygeine
- impetigo
- furuncles = clustered boils
____ is a common disease contracted from beaches or soil in tropical areas
cutaneous larva migrans (nematodes, hookworms)
primary skin infections are caused by (1) to affect (2); examples include: (3)
(primary pyodermas)
1- single pathogen
2- normal skin
3- S. aureus, β-hemolytis streptococci, coryneform bacteria
Secondary skin infections are defined as (1), caused by (2).
(secondary pyoderma)
1- infection of existing skin lesion (ex. insect bites, scratching, cracks, etc)
2- mix of infectious and non-infectious causes: scabies, psoriasis, poison ivy, atopic dermatitis, eczema, herpeticum, kerion
describe mechanism of ‘athletes’s foot’
- toe web infection – secondary pyoderma
- 1st thought to only be fungal infection
- Now thought dermatophytes (fungi) first must cause skin damage
- this allows bacterial growth of coryneform bacteria and brevibacterium (& Gram-)
compare macule, nodule, papule
- Macule: patch of skin altered in color, no elevation —- if >1cm diameter = patch
- Papule: small, solid, conical elevation of skin
- Nodule (tumor): small mass, rounded/irregular shape, palpable (slightly larger and extend deeper than papules)
define skin patch
- a macule >1 cm in diameter
- skin color alteration
- no elevation
define a bulla/vesicle (includ subtypes)
- small, abnormal elevation of outer layer of skin enclosing watery liquid
- Blister/Vesicle = 1-5 mm in diameter
- Bullae > 5 mm in diameter
examples of vesicle and bullae diseases
Vesicles: chickenpox (VVZ), oral herpes (HSV1), hand/foot/mouth disease
Bullae: bullous impetigo
define a pustule and its associated diseases
- small circumscribed elevation of skin containing pus w/ inflamed base
- acne, chickenpox (VVZ), smallpox
(T/F) pustules are always associated with hair follicles
F- they usually are, but not always
ex: folliculite, boils, chickenpox (VVZ)
define wheal (include examples)
- localized area of edema, usually irregular and variable in size and color
- ex: hive, insect bite
list the primary skin lesions
macule, papule, nodule, vesicle, bulla, pustule, wheal, plaque
list the secondary skin lesions
scale, crust, fissure, ulcer