Divisions of the Mesoderm Flashcards
Epimere/somatic/paraxial
-______: notochord
-Paraxial: gilid
Axial
Epimere/somatic/paraxial
-Axial: ________
-Paraxial: gilid
notochord
Epimere/somatic/paraxial
-Axial: notochord
-________: gilid
paraxial
Mesomere/Neck/Intermediate
-_________: gives rise to the kidneys
Nephrotome
Mesomere/Neck/Intermediate
-Nephrotome: gives rise to the _______
kidneys
hypomere/lateral plate
-gives rise to _______ ______
abdominal cavity
Habang neural fold is happening: mesomere is _______
dividing
Habang neural fold is happening: _______ is dividing
mesomere
Splitting of hypomere: ______, _______, _______
dermatome, myotome, sclerotome
Somite formation
- created from ______ ___
- divide into discrete units because of the expression of hairy genes
- Periodicity : caused by expression of hairy genes
- very interesting: starts out as pole cells
- expression of the genes: migrate, cells remain, go up/anteriorly
- expression becomes limited in anterior
- some parts split off from the main part
- expression in the posterior part: restricts and constricts
-90 minutes - cells di nagmimigrate pataas
- like a waves in the ocean: when they reach the shore, they leave something and then they go back to the ocean
paraxial rod
Somite formation
- created from paraxial rod
- divide into ______ units because of the expression of hairy genes
- Periodicity : caused by expression of hairy genes
- very interesting: starts out as pole cells
- expression of the genes: migrate, cells remain, go up/anteriorly
- expression becomes limited in anterior
- some parts split off from the main part
- expression in the posterior part: restricts and constricts
-90 minutes - cells di nagmimigrate pataas
- like a waves in the ocean: when they reach the shore, they leave something and then they go back to the ocean
discrete
Somite formation
- created from paraxial rod
- divide into discrete units because of the expression of ______ _____
- Periodicity : caused by expression of hairy genes
- very interesting: starts out as pole cells
- expression of the genes: migrate, cells remain, go up/anteriorly
- expression becomes limited in anterior
- some parts split off from the main part
- expression in the posterior part: restricts and constricts
-90 minutes - cells di nagmimigrate pataas
- like a waves in the ocean: when they reach the shore, they leave something and then they go back to the ocean
hairy genes
Somite formation
- created from paraxial rod
- divide into discrete units because of the expression of hairy genes
- __________ : caused by expression of hairy genes
- very interesting: starts out as pole cells
- expression of the genes: migrate, cells remain, go up/anteriorly
- expression becomes limited in anterior
- some parts split off from the main part
- expression in the posterior part: restricts and constricts
-90 minutes - cells di nagmimigrate pataas
- like a waves in the ocean: when they reach the shore, they leave something and then they go back to the ocean
Periodicity
Somite formation
- created from paraxial rod
- divide into discrete units because of the expression of hairy genes
- Periodicity : caused by expression of hairy genes
- very interesting: starts out as _____ _____
- expression of the genes: migrate, cells remain, go up/anteriorly
- expression becomes limited in anterior
- some parts split off from the main part
- expression in the posterior part: restricts and constricts
-90 minutes - cells di nagmimigrate pataas
- like a waves in the ocean: when they reach the shore, they leave something and then they go back to the ocean
pole cells
Somite formation
- created from paraxial rod
- divide into discrete units because of the expression of hairy genes
- Periodicity : caused by expression of hairy genes
- very interesting: starts out as pole cells
- expression of the genes: _______, cells remain, go up/anteriorly
- expression becomes limited in anterior
- some parts split off from the main part
- expression in the posterior part: restricts and constricts
-90 minutes - cells di nagmimigrate pataas
- like a waves in the ocean: when they reach the shore, they leave something and then they go back to the ocean
migrate
Somite formation
- created from paraxial rod
- divide into discrete units because of the expression of hairy genes
- Periodicity : caused by expression of hairy genes
- very interesting: starts out as pole cells
- expression of the genes: migrate, cells remain, go up/_______
- expression becomes limited in anterior
- some parts split off from the main part
- expression in the posterior part: restricts and constricts
-90 minutes - cells di nagmimigrate pataas
- like a waves in the ocean: when they reach the shore, they leave something and then they go back to the ocean
anteriorly
Somite formation
- created from paraxial rod
- divide into discrete units because of the expression of hairy genes
- Periodicity : caused by expression of hairy genes
- very interesting: starts out as pole cells
- expression of the genes: migrate, cells remain, go up/anteriorly
- expression becomes _______ in anterior
- some parts split off from the main part
- expression in the posterior part: restricts and constricts
-90 minutes - cells di nagmimigrate pataas
- like a waves in the ocean: when they reach the shore, they leave something and then they go back to the ocean
limited
Somite formation
- created from paraxial rod
- divide into discrete units because of the expression of hairy genes
- Periodicity : caused by expression of hairy genes
- very interesting: starts out as pole cells
- expression of the genes: migrate, cells remain, go up/anteriorly
- expression becomes limited in ______
- some parts split off from the main part
- expression in the posterior part: restricts and constricts
-90 minutes - cells di nagmimigrate pataas
- like a waves in the ocean: when they reach the shore, they leave something and then they go back to the ocean
anterior
Somite formation
- created from paraxial rod
- divide into discrete units because of the expression of hairy genes
- Periodicity : caused by expression of hairy genes
- very interesting: starts out as pole cells
- expression of the genes: migrate, cells remain, go up/anteriorly
- expression becomes limited in anterior
- some parts ______ ____from the main part
- expression in the posterior part: restricts and constricts
-90 minutes - cells di nagmimigrate pataas
- like a waves in the ocean: when they reach the shore, they leave something and then they go back to the ocean
split off
Somite formation
- created from paraxial rod
- divide into discrete units because of the expression of hairy genes
- Periodicity : caused by expression of hairy genes
- very interesting: starts out as pole cells
- expression of the genes: migrate, cells remain, go up/anteriorly
- expression becomes limited in anterior
- some parts split off from the main part
- expression in the ________ part: restricts and constricts
-90 minutes - cells di nagmimigrate pataas
- like a waves in the ocean: when they reach the shore, they leave something and then they go back to the ocean
posterior
Somite formation
- created from paraxial rod
- divide into discrete units because of the expression of hairy genes
- Periodicity : caused by expression of hairy genes
- very interesting: starts out as pole cells
- expression of the genes: migrate, cells remain, go up/anteriorly
- expression becomes limited in anterior
- some parts split off from the main part
- expression in the posterior part: _______ and constricts
-90 minutes - cells di nagmimigrate pataas
- like a waves in the ocean: when they reach the shore, they leave something and then they go back to the ocean
restricts
Somite formation
- created from paraxial rod
- divide into discrete units because of the expression of hairy genes
- Periodicity : caused by expression of hairy genes
- very interesting: starts out as pole cells
- expression of the genes: migrate, cells remain, go up/anteriorly
- expression becomes limited in anterior
- some parts split off from the main part
- expression in the posterior part: restricts and ________
-90 minutes - cells di nagmimigrate pataas
- like a waves in the ocean: when they reach the shore, they leave something and then they go back to the ocean
constricts
Somite formation
- created from paraxial rod
- divide into discrete units because of the expression of hairy genes
- Periodicity : caused by expression of hairy genes
- very interesting: starts out as pole cells
- expression of the genes: migrate, cells remain, go up/anteriorly
- expression becomes limited in anterior
- some parts split off from the main part
- expression in the posterior part: restricts and constricts
- __minutes
- cells di nagmimigrate pataas
- like a waves in the ocean: when they reach the shore, they leave something and then they go back to the ocean
90
Somite formation
- created from paraxial rod
- divide into discrete units because of the expression of hairy genes
- Periodicity : caused by expression of hairy genes
- very interesting: starts out as pole cells
- expression of the genes: migrate, cells remain, go up/anteriorly
- expression becomes limited in anterior
- some parts split off from the main part
- expression in the posterior part: restricts and constricts
-90 minutes - cells __ ________ pataas
- like a waves in the ocean: when they reach the shore, they leave something and then they go back to the ocean
di nagmimigrate
Somite Formation
__________ - caused by expression of fibronectin and cadherins which may in turn be brought about by the transcription factor, Paraxis
- from a mass of mesenchyme: they will start to form epithelium
- fibronectin forming a kind of mesenchyme around the cells
- cadherins for junctions that will form between the cells
Epithelialization
Somite Formation
Epithelialization - caused by expression of ________ and cadherins which may in turn be brought about by the transcription factor, Paraxis
- from a mass of mesenchyme: they will start to form epithelium
- fibronectin forming a kind of mesenchyme around the cells
- cadherins for junctions that will form between the cells
fibronectin
Somite Formation
Epithelialization - caused by expression of fibronectin and _______ which may in turn be brought about by the transcription factor, Paraxis
- from a mass of mesenchyme: they will start to form epithelium
- fibronectin forming a kind of mesenchyme around the cells
- cadherins for junctions that will form between the cells
cadherins
Somite Formation
Epithelialization - caused by expression of fibronectin and cadherins which may in turn be brought about by the ______ _____, Paraxis
- from a mass of mesenchyme: they will start to form epithelium
- fibronectin forming a kind of mesenchyme around the cells
- cadherins for junctions that will form between the cells
transcription factor
Somite Formation
Epithelialization - caused by expression of fibronectin and cadherins which may in turn be brought about by the transcription factor, ______
- from a mass of mesenchyme: they will start to form epithelium
- fibronectin forming a kind of mesenchyme around the cells
- cadherins for junctions that will form between the cells
Paraxis
Somite Formation
Epithelialization - caused by expression of fibronectin and cadherins which may in turn be brought about by the transcription factor, Paraxis
- from a mass of ________: they will start to form epithelium
- fibronectin forming a kind of mesenchyme around the cells
- cadherins for junctions that will form between the cells
mesenchyme
Somite Formation
Epithelialization - caused by expression of fibronectin and cadherins which may in turn be brought about by the transcription factor, Paraxis
- from a mass of mesenchyme: they will start to form _________
- fibronectin forming a kind of mesenchyme around the cells
- cadherins for junctions that will form between the cells
epithelium
Somite Formation
Epithelialization - caused by expression of fibronectin and cadherins which may in turn be brought about by the transcription factor, Paraxis
- from a mass of mesenchyme: they will start to form epithelium
- ________ forming a kind of mesenchyme around the cells
- cadherins for junctions that will form between the cells
fibronectin
Somite Formation
Epithelialization - caused by expression of fibronectin and cadherins which may in turn be brought about by the transcription factor, Paraxis
- from a mass of mesenchyme: they will start to form epithelium
- fibronectin forming a kind of _______ around the cells
- cadherins for junctions that will form between the cells
mesenchyme
Somite Formation
Epithelialization - caused by expression of fibronectin and cadherins which may in turn be brought about by the transcription factor, Paraxis
- from a mass of mesenchyme: they will start to form epithelium
- fibronectin forming a kind of mesenchyme around the cells
- ______ for junctions that will form between the cells
cadherins
Somite Formation
Epithelialization - caused by expression of fibronectin and cadherins which may in turn be brought about by the transcription factor, Paraxis
- from a mass of mesenchyme: they will start to form epithelium
- fibronectin forming a kind of mesenchyme around the cells
- cadherins for ________ that will form between the cells
junctions
Somite Formation
Epithelialization - caused by expression of fibronectin and cadherins which may in turn be brought about by the transcription factor, Paraxis
- from a mass of mesenchyme: they will start to form epithelium
- fibronectin forming a kind of mesenchyme ______ the cells
- cadherins for junctions that will form between the cells
around
Somite Formation
Epithelialization - caused by expression of fibronectin and cadherins which may in turn be brought about by the transcription factor, Paraxis
- from a mass of mesenchyme: they will start to form epithelium
- fibronectin forming a kind of mesenchyme around the cells
- cadherins for junctions that will form _______ the cells
between
_________ (axial specification occurs early in development; e.g. only certain somites from ribs)
- somites have different fates! But as they start they all look similar
- only certain somites will form vertebrae that will have ribs
Specification
Specification (____ specification occurs early in development; e.g. only certain somites from ribs)
- somites have different fates! But as they start they all look similar
- only certain somites will form vertebrae that will have ribs
axial
Specification (axial specification occurs _____ in development; e.g. only certain somites from ribs)
- somites have different fates! But as they start they all look similar
- only certain somites will form vertebrae that will have ribs
early
Specification (axial specification occurs early in development; e.g. only certain somites from ribs)
- ______ have different fates! But as they start they all look similar
- only certain somites will form vertebrae that will have ribs
somites
Specification (axial specification occurs early in development; e.g. only certain somites from ribs)
- somites have different _____! But as they start they all look similar
- only certain somites will form vertebrae that will have ribs
fates
Specification (axial specification occurs early in development; e.g. only certain somites from ribs)
- somites have different fates! But as they start they all look _______
- only certain somites will form vertebrae that will have ribs
similar
Specification (axial specification occurs early in development; e.g. only certain somites from ribs)
- somites have different fates! But as they start they all look similar
- only certain somites will form ______ that will have ribs
vertebrae
_________ within somites
- within the somite, they will differentiate
- myocoel: cavity
- from being epithelium: will again start to become mesenchymal again
- will be ready to migrate
- migrate just to surrounding: give rise to vertebrate
- surround the neural tube
- ventromedial somite: sclerotome
- dorsomedial, ventrolateral portion: myotome
- in between two: dermatome
- myotome: gives rise to muscles
- will form hypaxial muscles
- dermatome: dermis; give rise to dermis of back
Differentiation
Differentiation within somites
- within the ______, they will differentiate
- myocoel: cavity
- from being epithelium: will again start to become mesenchymal again
- will be ready to migrate
- migrate just to surrounding: give rise to vertebrate
- surround the neural tube
- ventromedial somite: sclerotome
- dorsomedial, ventrolateral portion: myotome
- in between two: dermatome
- myotome: gives rise to muscles
- will form hypaxial muscles
- dermatome: dermis; give rise to dermis of back
somite
Differentiation within somites
- within the somite, they will differentiate
- ______: cavity
- from being epithelium: will again start to become mesenchymal again
- will be ready to migrate
- migrate just to surrounding: give rise to vertebrate
- surround the neural tube
- ventromedial somite: sclerotome
- dorsomedial, ventrolateral portion: myotome
- in between two: dermatome
- myotome: gives rise to muscles
- will form hypaxial muscles
- dermatome: dermis; give rise to dermis of back
myocoel
Differentiation within somites
- within the somite, they will differentiate
- myocoel: _______
- from being epithelium: will again start to become mesenchymal again
- will be ready to migrate
- migrate just to surrounding: give rise to vertebrate
- surround the neural tube
- ventromedial somite: sclerotome
- dorsomedial, ventrolateral portion: myotome
- in between two: dermatome
- myotome: gives rise to muscles
- will form hypaxial muscles
- dermatome: dermis; give rise to dermis of back
cavity
Differentiation within somites
- within the somite, they will differentiate
- myocoel: cavity
- from being _______: will again start to become mesenchymal again
- will be ready to migrate
- migrate just to surrounding: give rise to vertebrate
- surround the neural tube
- ventromedial somite: sclerotome
- dorsomedial, ventrolateral portion: myotome
- in between two: dermatome
- myotome: gives rise to muscles
- will form hypaxial muscles
- dermatome: dermis; give rise to dermis of back
epithelium
Differentiation within somites
- within the somite, they will differentiate
- myocoel: cavity
- from being epithelium: will again start to become ________ again
- will be ready to migrate
- migrate just to surrounding: give rise to vertebrate
- surround the neural tube
- ventromedial somite: sclerotome
- dorsomedial, ventrolateral portion: myotome
- in between two: dermatome
- myotome: gives rise to muscles
- will form hypaxial muscles
- dermatome: dermis; give rise to dermis of back
mesenchymal
Differentiation within somites
- within the somite, they will differentiate
- myocoel: cavity
- from being epithelium: will again start to become mesenchymal again
- will be ready to ______
- migrate just to surrounding: give rise to vertebrate
- surround the neural tube
- ventromedial somite: sclerotome
- dorsomedial, ventrolateral portion: myotome
- in between two: dermatome
- myotome: gives rise to muscles
- will form hypaxial muscles
- dermatome: dermis; give rise to dermis of back
migrate
Differentiation within somites
- within the somite, they will differentiate
- myocoel: cavity
- from being epithelium: will again start to become mesenchymal again
- will be ready to migrate
- migrate just to ________ : give rise to vertebrate
- surround the neural tube
- ventromedial somite: sclerotome
- dorsomedial, ventrolateral portion: myotome
- in between two: dermatome
- myotome: gives rise to muscles
- will form hypaxial muscles
- dermatome: dermis; give rise to dermis of back
surrounding
Differentiation within somites
- within the somite, they will differentiate
- myocoel: cavity
- from being epithelium: will again start to become mesenchymal again
- will be ready to migrate
- migrate just to surrounding: give rise to ________
- surround the neural tube
- ventromedial somite: sclerotome
- dorsomedial, ventrolateral portion: myotome
- in between two: dermatome
- myotome: gives rise to muscles
- will form hypaxial muscles
- dermatome: dermis; give rise to dermis of back
vertebrate
Differentiation within somites
- within the somite, they will differentiate
- myocoel: cavity
- from being epithelium: will again start to become mesenchymal again
- will be ready to migrate
- migrate just to surrounding: give rise to vertebrate
- _______ the neural tube
- ventromedial somite: sclerotome
- dorsomedial, ventrolateral portion: myotome
- in between two: dermatome
- myotome: gives rise to muscles
- will form hypaxial muscles
- dermatome: dermis; give rise to dermis of back
surround
Differentiation within somites
- within the somite, they will differentiate
- myocoel: cavity
- from being epithelium: will again start to become mesenchymal again
- will be ready to migrate
- migrate just to surrounding: give rise to vertebrate
- surround the _______ _____
- ventromedial somite: sclerotome
- dorsomedial, ventrolateral portion: myotome
- in between two: dermatome
- myotome: gives rise to muscles
- will form hypaxial muscles
- dermatome: dermis; give rise to dermis of back
neural tube
Differentiation within somites
- within the somite, they will differentiate
- myocoel: cavity
- from being epithelium: will again start to become mesenchymal again
- will be ready to migrate
- migrate just to surrounding: give rise to vertebrate
- surround the neural tube
- _________ somite: sclerotome
- dorsomedial, ventrolateral portion: myotome
- in between two: dermatome
- myotome: gives rise to muscles
- will form hypaxial muscles
- dermatome: dermis; give rise to dermis of back
ventromedial
Differentiation within somites
- within the somite, they will differentiate
- myocoel: cavity
- from being epithelium: will again start to become mesenchymal again
- will be ready to migrate
- migrate just to surrounding: give rise to vertebrate
- surround the neural tube
- ventromedial somite: ________
- dorsomedial, ventrolateral portion: myotome
- in between two: dermatome
- myotome: gives rise to muscles
- will form hypaxial muscles
- dermatome: dermis; give rise to dermis of back
sclerotome
Differentiation within somites
- within the somite, they will differentiate
- myocoel: cavity
- from being epithelium: will again start to become mesenchymal again
- will be ready to migrate
- migrate just to surrounding: give rise to vertebrate
- surround the neural tube
- ventromedial somite: sclerotome
- _________, ventrolateral portion: myotome
- in between two: dermatome
- myotome: gives rise to muscles
- will form hypaxial muscles
- dermatome: dermis; give rise to dermis of back
dorsomedial
Differentiation within somites
- within the somite, they will differentiate
- myocoel: cavity
- from being epithelium: will again start to become mesenchymal again
- will be ready to migrate
- migrate just to surrounding: give rise to vertebrate
- surround the neural tube
- ventromedial somite: sclerotome
- dorsomedial, __________ portion: myotome
- in between two: dermatome
- myotome: gives rise to muscles
- will form hypaxial muscles
- dermatome: dermis; give rise to dermis of back
ventrolateral
Differentiation within somites
- within the somite, they will differentiate
- myocoel: cavity
- from being epithelium: will again start to become mesenchymal again
- will be ready to migrate
- migrate just to surrounding: give rise to vertebrate
- surround the neural tube
- ventromedial somite: sclerotome
- dorsomedial, ventrolateral portion: ________
- in between two: dermatome
- myotome: gives rise to muscles
- will form hypaxial muscles
- dermatome: dermis; give rise to dermis of back
myotome
Differentiation within somites
- within the somite, they will differentiate
- myocoel: cavity
- from being epithelium: will again start to become mesenchymal again
- will be ready to migrate
- migrate just to surrounding: give rise to vertebrate
- surround the neural tube
- ventromedial somite: sclerotome
- dorsomedial, ventrolateral portion: myotome
- in between _____: dermatome
- myotome: gives rise to muscles
- will form hypaxial muscles
- dermatome: dermis; give rise to dermis of back
two
Differentiation within somites
- within the somite, they will differentiate
- myocoel: cavity
- from being epithelium: will again start to become mesenchymal again
- will be ready to migrate
- migrate just to surrounding: give rise to vertebrate
- surround the neural tube
- ventromedial somite: sclerotome
- dorsomedial, ventrolateral portion: myotome
- in between two: _______
- myotome: gives rise to muscles
- will form hypaxial muscles
- dermatome: dermis; give rise to dermis of back
dermatome
Differentiation within somites
- within the somite, they will differentiate
- myocoel: cavity
- from being epithelium: will again start to become mesenchymal again
- will be ready to migrate
- migrate just to surrounding: give rise to vertebrate
- surround the neural tube
- ventromedial somite: sclerotome
- dorsomedial, ventrolateral portion: myotome
- in between two: dermatome
- _________ : gives rise to muscles
- will form hypaxial muscles
- dermatome: dermis; give rise to dermis of back
myotome
Differentiation within somites
- within the somite, they will differentiate
- myocoel: cavity
- from being epithelium: will again start to become mesenchymal again
- will be ready to migrate
- migrate just to surrounding: give rise to vertebrate
- surround the neural tube
- ventromedial somite: sclerotome
- dorsomedial, ventrolateral portion: myotome
- in between two: dermatome
- myotome: gives rise to ______
- will form hypaxial muscles
- dermatome: dermis; give rise to dermis of back
muscles
Differentiation within somites
- within the somite, they will differentiate
- myocoel: cavity
- from being epithelium: will again start to become mesenchymal again
- will be ready to migrate
- migrate just to surrounding: give rise to vertebrate
- surround the neural tube
- ventromedial somite: sclerotome
- dorsomedial, ventrolateral portion: myotome
- in between two: dermatome
- myotome: gives rise to muscles
- will form ________ muscles
- dermatome: dermis; give rise to dermis of back
hypaxial
Differentiation within somites
- within the somite, they will differentiate
- myocoel: cavity
- from being epithelium: will again start to become mesenchymal again
- will be ready to migrate
- migrate just to surrounding: give rise to vertebrate
- surround the neural tube
- ventromedial somite: sclerotome
- dorsomedial, ventrolateral portion: myotome
- in between two: dermatome
- myotome: gives rise to muscles
- will form hypaxial muscles
- __________: dermis; give rise to dermis of back
dermatome
Differentiation within somites
- within the somite, they will differentiate
- myocoel: cavity
- from being epithelium: will again start to become mesenchymal again
- will be ready to migrate
- migrate just to surrounding: give rise to vertebrate
- surround the neural tube
- ventromedial somite: sclerotome
- dorsomedial, ventrolateral portion: myotome
- in between two: dermatome
- myotome: gives rise to muscles
- will form hypaxial muscles
- dermatome: ______; give rise to dermis of back
dermis
Differentiation within somites
- within the somite, they will differentiate
- myocoel: cavity
- from being epithelium: will again start to become mesenchymal again
- will be ready to migrate
- migrate just to surrounding: give rise to vertebrate
- surround the neural tube
- ventromedial somite: sclerotome
- dorsomedial, ventrolateral portion: myotome
- in between two: dermatome
- myotome: gives rise to muscles
- will form hypaxial muscles
- dermatome: dermis; give rise to dermis of _____
back
Epimere/ Somites
divides into:
_________
- induced by Shh from notochord and expresses Pax 1
Myotome
- induced by Wnt (1,3) from dorsal neural tube for epaxial muscle pathway and BMP4 and FGF from lateral plate mesoderm for hypaxial musculature
Sclerotome
_______/ Somites
divides into:
Sclerotome
- induced by Shh from notochord and expresses Pax 1
Myotome
- induced by Wnt (1,3) from dorsal neural tube for epaxial muscle pathway and BMP4 and FGF from lateral plate mesoderm for hypaxial musculature
Epimere
Epimere/ Somites
divides into:
Sclerotome
- induced by _____ from notochord and expresses Pax 1
Myotome
- induced by Wnt (1,3) from dorsal neural tube for epaxial muscle pathway and BMP4 and FGF from lateral plate mesoderm for hypaxial musculature
Shh
Epimere/ Somites
divides into:
Sclerotome
- induced by Shh from ______ and expresses Pax 1
Myotome
- induced by Wnt (1,3) from dorsal neural tube for epaxial muscle pathway and BMP4 and FGF from lateral plate mesoderm for hypaxial musculature
notochord
Epimere/ Somites
divides into:
Sclerotome
- induced by Shh from notochord and expresses _____ _
Myotome
- induced by Wnt (1,3) from dorsal neural tube for epaxial muscle pathway and BMP4 and FGF from lateral plate mesoderm for hypaxial musculature
Pax 1
Epimere/ Somites
divides into:
Sclerotome
- induced by Shh from notochord and expresses Pax 1
_______
- induced by Wnt (1,3) from dorsal neural tube for epaxial muscle pathway and BMP4 and FGF from lateral plate mesoderm for hypaxial musculature
Myotome
Epimere/ Somites
divides into:
Sclerotome
- induced by Shh from notochord and expresses Pax 1
Myotome
- induced by ______ from dorsal neural tube for epaxial muscle pathway and BMP4 and FGF from lateral plate mesoderm for hypaxial musculature
Wnt (1,3)
Epimere/ Somites
divides into:
Sclerotome
- induced by Shh from notochord and expresses Pax 1
Myotome
- induced by Wnt (1,3) from ______ _____ _____ for epaxial muscle pathway and BMP4 and FGF from lateral plate mesoderm for hypaxial musculature
dorsal neural tube
Epimere/ Somites
divides into:
Sclerotome
- induced by Shh from notochord and expresses Pax 1
Myotome
- induced by Wnt (1,3) from dorsal neural tube for ______ _____ _______and BMP4 and FGF from lateral plate mesoderm for hypaxial musculature
epaxial muscle pathway
Epimere/ Somites
divides into:
Sclerotome
- induced by Shh from notochord and expresses Pax 1
Myotome
- induced by Wnt (1,3) from dorsal neural tube for epaxial muscle pathway and ______ and _____ from lateral plate mesoderm for hypaxial musculature
BMP4, FGF
Epimere/ Somites
divides into:
Sclerotome
- induced by Shh from notochord and expresses Pax 1
Myotome
- induced by Wnt (1,3) from dorsal neural tube for epaxial muscle pathway and BMP4 and FGF from _______ _____ mesoderm for hypaxial musculature
lateral plate
Epimere/ Somites
divides into:
Sclerotome
- induced by Shh from notochord and expresses Pax 1
Myotome
- induced by Wnt (1,3) from dorsal neural tube for epaxial muscle pathway and BMP4 and FGF from lateral plate mesoderm for _______ ________
hypaxial musculature
Epimere/ Somites (cont’d)
- _____ and proteins as inducers of certain structures
- notochord produces Shh; also has a role in the induction of sclerotome
- without Shh: sclerotome will not form
- start to secrete Pax1: beginning of conversion to sclerotome
- dorsal part: Wnt 1 and 3: influence on dorsomedial portion of somite: becomes the dorsal myotome
- dorsal part of neural tube: secrete neurotrophin 3: signals to form dermatome
- Pax 3 and 7: are also important in formation of dermatome
- form differently because of different inducers
- BMP 4, FGF5: from the lateral plate
genes
Epimere/ Somites (cont’d)
-genes and ______ as inducers of certain structures
- notochord produces Shh; also has a role in the induction of sclerotome
- without Shh: sclerotome will not form
- start to secrete Pax1: beginning of conversion to sclerotome
- dorsal part: Wnt 1 and 3: influence on dorsomedial portion of somite: becomes the dorsal myotome
- dorsal part of neural tube: secrete neurotrophin 3: signals to form dermatome
- Pax 3 and 7: are also important in formation of dermatome
- form differently because of different inducers
- BMP 4, FGF5: from the lateral plate
proteins
Epimere/ Somites (cont’d)
-genes and proteins as _______ of certain structures
- notochord produces Shh; also has a role in the induction of sclerotome
- without Shh: sclerotome will not form
- start to secrete Pax1: beginning of conversion to sclerotome
- dorsal part: Wnt 1 and 3: influence on dorsomedial portion of somite: becomes the dorsal myotome
- dorsal part of neural tube: secrete neurotrophin 3: signals to form dermatome
- Pax 3 and 7: are also important in formation of dermatome
- form differently because of different inducers
- BMP 4, FGF5: from the lateral plate
inducers
Epimere/ Somites (cont’d)
-genes and proteins as inducers of certain structures
- ______ produces Shh; also has a role in the induction of sclerotome
- without Shh: sclerotome will not form
- start to secrete Pax1: beginning of conversion to sclerotome
- dorsal part: Wnt 1 and 3: influence on dorsomedial portion of somite: becomes the dorsal myotome
- dorsal part of neural tube: secrete neurotrophin 3: signals to form dermatome
- Pax 3 and 7: are also important in formation of dermatome
- form differently because of different inducers
- BMP 4, FGF5: from the lateral plate
notochord
Epimere/ Somites (cont’d)
-genes and proteins as inducers of certain structures
- notochord produces ____; also has a role in the induction of sclerotome
- without Shh: sclerotome will not form
- start to secrete Pax1: beginning of conversion to sclerotome
- dorsal part: Wnt 1 and 3: influence on dorsomedial portion of somite: becomes the dorsal myotome
- dorsal part of neural tube: secrete neurotrophin 3: signals to form dermatome
- Pax 3 and 7: are also important in formation of dermatome
- form differently because of different inducers
- BMP 4, FGF5: from the lateral plate
Shh
Epimere/ Somites (cont’d)
-genes and proteins as inducers of certain structures
- notochord produces Shh; also has a role in the induction of _______
- without Shh: sclerotome will not form
- start to secrete Pax1: beginning of conversion to sclerotome
- dorsal part: Wnt 1 and 3: influence on dorsomedial portion of somite: becomes the dorsal myotome
- dorsal part of neural tube: secrete neurotrophin 3: signals to form dermatome
- Pax 3 and 7: are also important in formation of dermatome
- form differently because of different inducers
- BMP 4, FGF5: from the lateral plate
sclerotome
Epimere/ Somites (cont’d)
-genes and proteins as inducers of certain structures
- notochord produces Shh; also has a role in the induction of sclerotome
- without _____ : sclerotome will not form
- start to secrete Pax1: beginning of conversion to sclerotome
- dorsal part: Wnt 1 and 3: influence on dorsomedial portion of somite: becomes the dorsal myotome
- dorsal part of neural tube: secrete neurotrophin 3: signals to form dermatome
- Pax 3 and 7: are also important in formation of dermatome
- form differently because of different inducers
- BMP 4, FGF5: from the lateral plate
Shh
Epimere/ Somites (cont’d)
-genes and proteins as inducers of certain structures
- notochord produces Shh; also has a role in the induction of sclerotome
- without Shh: sclerotome will not form
- start to secrete ______ : beginning of conversion to sclerotome
- dorsal part: Wnt 1 and 3: influence on dorsomedial portion of somite: becomes the dorsal myotome
- dorsal part of neural tube: secrete neurotrophin 3: signals to form dermatome
- Pax 3 and 7: are also important in formation of dermatome
- form differently because of different inducers
- BMP 4, FGF5: from the lateral plate
Pax1
Epimere/ Somites (cont’d)
-genes and proteins as inducers of certain structures
- notochord produces Shh; also has a role in the induction of sclerotome
- without Shh: sclerotome will not form
- start to secrete Pax1: beginning of ______ to sclerotome
- dorsal part: Wnt 1 and 3: influence on dorsomedial portion of somite: becomes the dorsal myotome
- dorsal part of neural tube: secrete neurotrophin 3: signals to form dermatome
- Pax 3 and 7: are also important in formation of dermatome
- form differently because of different inducers
- BMP 4, FGF5: from the lateral plate
conversion
Epimere/ Somites (cont’d)
-genes and proteins as inducers of certain structures
- notochord produces Shh; also has a role in the induction of sclerotome
- without Shh: sclerotome will not form
- start to secrete Pax1: beginning of conversion to ________
- dorsal part: Wnt 1 and 3: influence on dorsomedial portion of somite: becomes the dorsal myotome
- dorsal part of neural tube: secrete neurotrophin 3: signals to form dermatome
- Pax 3 and 7: are also important in formation of dermatome
- form differently because of different inducers
- BMP 4, FGF5: from the lateral plate
sclerotome
Epimere/ Somites (cont’d)
-genes and proteins as inducers of certain structures
- notochord produces Shh; also has a role in the induction of sclerotome
- without Shh: sclerotome will not form
- start to secrete Pax1: beginning of conversion to sclerotome
- ______ part: Wnt 1 and 3: influence on dorsomedial portion of somite: becomes the dorsal myotome
- dorsal part of neural tube: secrete neurotrophin 3: signals to form dermatome
- Pax 3 and 7: are also important in formation of dermatome
- form differently because of different inducers
- BMP 4, FGF5: from the lateral plate
dorsal
Epimere/ Somites (cont’d)
-genes and proteins as inducers of certain structures
- notochord produces Shh; also has a role in the induction of sclerotome
- without Shh: sclerotome will not form
- start to secrete Pax1: beginning of conversion to sclerotome
- dorsal part: ___ _ and _: influence on dorsomedial portion of somite: becomes the dorsal myotome
- dorsal part of neural tube: secrete neurotrophin 3: signals to form dermatome
- Pax 3 and 7: are also important in formation of dermatome
- form differently because of different inducers
- BMP 4, FGF5: from the lateral plate
Wnt 1 and 3
Epimere/ Somites (cont’d)
-genes and proteins as inducers of certain structures
- notochord produces Shh; also has a role in the induction of sclerotome
- without Shh: sclerotome will not form
- start to secrete Pax1: beginning of conversion to sclerotome
- dorsal part: Wnt 1 and 3: influence on _______ portion of somite: becomes the dorsal myotome
- dorsal part of neural tube: secrete neurotrophin 3: signals to form dermatome
- Pax 3 and 7: are also important in formation of dermatome
- form differently because of different inducers
- BMP 4, FGF5: from the lateral plate
dorsomedial
Epimere/ Somites (cont’d)
-genes and proteins as inducers of certain structures
- notochord produces Shh; also has a role in the induction of sclerotome
- without Shh: sclerotome will not form
- start to secrete Pax1: beginning of conversion to sclerotome
- dorsal part: Wnt 1 and 3: influence on dorsomedial portion of somite: becomes the _______ ______
- dorsal part of neural tube: secrete neurotrophin 3: signals to form dermatome
- Pax 3 and 7: are also important in formation of dermatome
- form differently because of different inducers
- BMP 4, FGF5: from the lateral plate
dorsal myotome
Epimere/ Somites (cont’d)
-genes and proteins as inducers of certain structures
- notochord produces Shh; also has a role in the induction of sclerotome
- without Shh: sclerotome will not form
- start to secrete Pax1: beginning of conversion to sclerotome
- dorsal part: Wnt 1 and 3: influence on dorsomedial portion of somite: becomes the dorsal myotome
- ______ part of neural tube: secrete neurotrophin 3: signals to form dermatome
- Pax 3 and 7: are also important in formation of dermatome
- form differently because of different inducers
- BMP 4, FGF5: from the lateral plate
dorsal
Epimere/ Somites (cont’d)
-genes and proteins as inducers of certain structures
- notochord produces Shh; also has a role in the induction of sclerotome
- without Shh: sclerotome will not form
- start to secrete Pax1: beginning of conversion to sclerotome
- dorsal part: Wnt 1 and 3: influence on dorsomedial portion of somite: becomes the dorsal myotome
- dorsal part of ______ ____: secrete neurotrophin 3: signals to form dermatome
- Pax 3 and 7: are also important in formation of dermatome
- form differently because of different inducers
- BMP 4, FGF5: from the lateral plate
neural tube
Epimere/ Somites (cont’d)
-genes and proteins as inducers of certain structures
- notochord produces Shh; also has a role in the induction of sclerotome
- without Shh: sclerotome will not form
- start to secrete Pax1: beginning of conversion to sclerotome
- dorsal part: Wnt 1 and 3: influence on dorsomedial portion of somite: becomes the dorsal myotome
- dorsal part of neural tube: secrete _______ __: signals to form dermatome
- Pax 3 and 7: are also important in formation of dermatome
- form differently because of different inducers
- BMP 4, FGF5: from the lateral plate
neurotrophin 3
Epimere/ Somites (cont’d)
-genes and proteins as inducers of certain structures
- notochord produces Shh; also has a role in the induction of sclerotome
- without Shh: sclerotome will not form
- start to secrete Pax1: beginning of conversion to sclerotome
- dorsal part: Wnt 1 and 3: influence on dorsomedial portion of somite: becomes the dorsal myotome
- dorsal part of neural tube: secrete neurotrophin 3: signals to form _______
- Pax 3 and 7: are also important in formation of dermatome
- form differently because of different inducers
- BMP 4, FGF5: from the lateral plate
dermatome
Epimere/ Somites (cont’d)
-genes and proteins as inducers of certain structures
- notochord produces Shh; also has a role in the induction of sclerotome
- without Shh: sclerotome will not form
- start to secrete Pax1: beginning of conversion to sclerotome
- dorsal part: Wnt 1 and 3: influence on dorsomedial portion of somite: becomes the dorsal myotome
- dorsal part of neural tube: secrete neurotrophin 3: signals to form dermatome
- ______ _ and _: are also important in formation of dermatome
- form differently because of different inducers
- BMP 4, FGF5: from the lateral plate
Pax 3 and 7
Epimere/ Somites (cont’d)
-genes and proteins as inducers of certain structures
- notochord produces Shh; also has a role in the induction of sclerotome
- without Shh: sclerotome will not form
- start to secrete Pax1: beginning of conversion to sclerotome
- dorsal part: Wnt 1 and 3: influence on dorsomedial portion of somite: becomes the dorsal myotome
- dorsal part of neural tube: secrete neurotrophin 3: signals to form dermatome
- Pax 3 and 7: are also important in formation of ________
- form differently because of different inducers
- BMP 4, FGF5: from the lateral plate
dermatome
Epimere/ Somites (cont’d)
-genes and proteins as inducers of certain structures
- notochord produces Shh; also has a role in the induction of sclerotome
- without Shh: sclerotome will not form
- start to secrete Pax1: beginning of conversion to sclerotome
- dorsal part: Wnt 1 and 3: influence on dorsomedial portion of somite: becomes the dorsal myotome
- dorsal part of neural tube: secrete neurotrophin 3: signals to form dermatome
- Pax 3 and 7: are also important in formation of dermatome
- form ________ because of different inducers
- BMP 4, FGF5: from the lateral plate
differently
Epimere/ Somites (cont’d)
-genes and proteins as inducers of certain structures
- notochord produces Shh; also has a role in the induction of sclerotome
- without Shh: sclerotome will not form
- start to secrete Pax1: beginning of conversion to sclerotome
- dorsal part: Wnt 1 and 3: influence on dorsomedial portion of somite: becomes the dorsal myotome
- dorsal part of neural tube: secrete neurotrophin 3: signals to form dermatome
- Pax 3 and 7: are also important in formation of dermatome
- form differently because of different _______
- BMP 4, FGF5: from the lateral plate
inducers
Epimere/ Somites (cont’d)
-genes and proteins as inducers of certain structures
- notochord produces Shh; also has a role in the induction of sclerotome
- without Shh: sclerotome will not form
- start to secrete Pax1: beginning of conversion to sclerotome
- dorsal part: Wnt 1 and 3: influence on dorsomedial portion of somite: becomes the dorsal myotome
- dorsal part of neural tube: secrete neurotrophin 3: signals to form dermatome
- Pax 3 and 7: are also important in formation of dermatome
- form differently because of different inducers
- ______ __, FGF5: from the lateral plate
BMP 4
Epimere/ Somites (cont’d)
-genes and proteins as inducers of certain structures
- notochord produces Shh; also has a role in the induction of sclerotome
- without Shh: sclerotome will not form
- start to secrete Pax1: beginning of conversion to sclerotome
- dorsal part: Wnt 1 and 3: influence on dorsomedial portion of somite: becomes the dorsal myotome
- dorsal part of neural tube: secrete neurotrophin 3: signals to form dermatome
- Pax 3 and 7: are also important in formation of dermatome
- form differently because of different inducers
- BMP 4, ______: from the lateral plate
FGF 5
Epimere/ Somites (cont’d)
-genes and proteins as inducers of certain structures
- notochord produces Shh; also has a role in the induction of sclerotome
- without Shh: sclerotome will not form
- start to secrete Pax1: beginning of conversion to sclerotome
- dorsal part: Wnt 1 and 3: influence on dorsomedial portion of somite: becomes the dorsal myotome
- dorsal part of neural tube: secrete neurotrophin 3: signals to form dermatome
- Pax 3 and 7: are also important in formation of dermatome
- form differently because of different inducers
- BMP 4, FGF5: from the _____ plate
lateral
Development of the _______
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and segmentation of vertebral column
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one long rod
Sclerotome
Development of the Sclerotome
- development is not straight but ______
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and segmentation of vertebral column
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one long rod
segmental
Development of the Sclerotome
- development is ___ ______ but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and segmentation of vertebral column
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one long rod
not straight
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of _______
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and segmentation of vertebral column
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one long rod
vertebrae
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of ____ ______ expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and segmentation of vertebral column
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one long rod
Hox genes
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in ____________ patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and segmentation of vertebral column
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one long rod
anteroposterior
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of _____ _____
- roles of spinal ganglia and notochord in morphogenesis and segmentation of vertebral column
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one long rod
vertebral column
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of _____ _____ and notochord in morphogenesis and segmentation of vertebral column
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one long rod
spinal ganglia
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and ______ in morphogenesis and segmentation of vertebral column
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one long rod
notochord
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in _______ and segmentation of vertebral column
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one long rod
morphogenesis
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and ________ of vertebral column
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one long rod
segmentation
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and segmentation of ______ _____
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one long rod
vertebral column
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and segmentation of vertebral column
- ______ ______: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one long rod
spinal ganglia
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and segmentation of vertebral column
- spinal ganglia: from ______ _____: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one long rod
neural crest
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and segmentation of vertebral column
- spinal ganglia: from neural crest: that _______ to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one long rod
migrate
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and segmentation of vertebral column
- spinal ganglia: from neural crest: that migrate to the ______ ____ in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one long rod
neural tube
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and segmentation of vertebral column
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- _______ ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one long rod
notochord
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and segmentation of vertebral column
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ______ ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one long rod
ilalim
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and segmentation of vertebral column
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng _____ ____
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one long rod
neural tube
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and segmentation of vertebral column
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- _______ of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one long rod
induction
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and segmentation of vertebral column
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag _____: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one long rod
removed
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and segmentation of vertebral column
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: _______ is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one long rod
segmentation
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and segmentation of vertebral column
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, ______ ang vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one long rod
dikit2
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and segmentation of vertebral column
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and _________: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one long rod
vertebrae
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and segmentation of vertebral column
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole _____ ___ structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one long rod
solid rod
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and segmentation of vertebral column
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be _______ so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one long rod
present
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and segmentation of vertebral column
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- ______ ______ has to be present so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one long rod
spinal ganglia
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and segmentation of vertebral column
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that ______ area will be segmented
- if you remove the notochord: ventral portion will form one long rod
dorsal
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and segmentation of vertebral column
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be ________
- if you remove the notochord: ventral portion will form one long rod
segmented
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and segmentation of vertebral column
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the _______: ventral portion will form one long rod
notochord
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and segmentation of vertebral column
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the notochord: _______ portion will form one long rod
ventral
Development of the Sclerotome
- development is not straight but segmental
Segmental arrangement of vertebrae
- role of Hox genes expression in anteroposterior patterning of vertebral column
- roles of spinal ganglia and notochord in morphogenesis and segmentation of vertebral column
- spinal ganglia: from neural crest: that migrate to the neural tube in a certain pattern
- notochord ay nasa ilalim ng neural tube
- induction of spinal ganglia: pag removed: segmentation is removed, dikit² and vertebrae: one whole solid rod structure
- spinal ganglia has to be present so that dorsal area will be segmented
- if you remove the notochord: ventral portion will form one ____ ____
long rod
Repatterning of sclerotome in formation of _______
- somites have given rise to sclerotome and myotome
- however, in the course of the dev, especially in the dev of spinal nerve
- it induces the splitting of sclerotome into two
- in such a way that the posterior portion will fuse with anterior of previous
- myotome stays in place
- muscles are in between
vertebrae
Repatterning of sclerotome in formation of vertebrae
- ______ have given rise to sclerotome and myotome
- however, in the course of the dev, especially in the dev of spinal nerve
- it induces the splitting of sclerotome into two
- in such a way that the posterior portion will fuse with anterior of previous
- myotome stays in place
- muscles are in between
somites
Repatterning of sclerotome in formation of vertebrae
- somites have given rise to ______ and _____
- however, in the course of the dev, especially in the dev of spinal nerve
- it induces the splitting of sclerotome into two
- in such a way that the posterior portion will fuse with anterior of previous
- myotome stays in place
- muscles are in between
sclerotome, myotome
Repatterning of sclerotome in formation of vertebrae
- somites have given rise to sclerotome and myotome
- however, in the course of the dev, especially in the dev of ______ _____
- it induces the splitting of sclerotome into two
- in such a way that the posterior portion will fuse with anterior of previous
- myotome stays in place
- muscles are in between
spinal nerve
Repatterning of sclerotome in formation of vertebrae
- somites have given rise to sclerotome and myotome
- however, in the course of the dev, especially in the dev of spinal nerve
- it induces the ______ of sclerotome into two
- in such a way that the posterior portion will fuse with anterior of previous
- myotome stays in place
- muscles are in between
splitting
Repatterning of sclerotome in formation of vertebrae
- somites have given rise to sclerotome and myotome
- however, in the course of the dev, especially in the dev of spinal nerve
- it induces the splitting of ________ into two
- in such a way that the posterior portion will fuse with anterior of previous
- myotome stays in place
- muscles are in between
sclerotome
Repatterning of sclerotome in formation of vertebrae
- somites have given rise to sclerotome and myotome
- however, in the course of the dev, especially in the dev of spinal nerve
- it induces the splitting of sclerotome into ___
- in such a way that the posterior portion will fuse with anterior of previous
- myotome stays in place
- muscles are in between
two
Repatterning of sclerotome in formation of vertebrae
- somites have given rise to sclerotome and myotome
- however, in the course of the dev, especially in the dev of spinal nerve
- it induces the splitting of sclerotome into two
- in such a way that the _____ portion will fuse with anterior of previous
- myotome stays in place
- muscles are in between
posterior
Repatterning of sclerotome in formation of vertebrae
- somites have given rise to sclerotome and myotome
- however, in the course of the dev, especially in the dev of spinal nerve
- it induces the splitting of sclerotome into two
- in such a way that the posterior portion will ____ with anterior of previous
- myotome stays in place
- muscles are in between
fuse
Repatterning of sclerotome in formation of vertebrae
- somites have given rise to sclerotome and myotome
- however, in the course of the dev, especially in the dev of spinal nerve
- it induces the splitting of sclerotome into two
- in such a way that the posterior portion will fuse with ______ of previous
- myotome stays in place
- muscles are in between
anterior
Repatterning of sclerotome in formation of vertebrae
- somites have given rise to sclerotome and myotome
- however, in the course of the dev, especially in the dev of spinal nerve
- it induces the splitting of sclerotome into two
- in such a way that the posterior portion will fuse with anterior of previous
- ______ stays in place
- muscles are in between
myotome
Repatterning of sclerotome in formation of vertebrae
- somites have given rise to sclerotome and myotome
- however, in the course of the dev, especially in the dev of spinal nerve
- it induces the splitting of sclerotome into two
- in such a way that the posterior portion will fuse with anterior of previous
- myotome stays in place
- ______ are in between
muscles
_______ bone formation
First Phase
- mesenchyme (in sclerotome, limbs) is induced to secrete Pax 1 and Scleraxis: activate cartilage specific genes
- transcription factors: promote transcription of other genes downstream
- have to be present, genes downstream will not function without them
- unless the genes function in a redundant manner
Endochondral
Endochondral bone formation
_______ _____
- mesenchyme (in sclerotome, limbs) is induced to secrete Pax 1 and Scleraxis: activate cartilage specific genes
- transcription factors: promote transcription of other genes downstream
- have to be present, genes downstream will not function without them
- unless the genes function in a redundant manner
First phase
Endochondral bone formation
First Phase
- _______ (in sclerotome, limbs) is induced to secrete Pax 1 and Scleraxis: activate cartilage specific genes
- transcription factors: promote transcription of other genes downstream
- have to be present, genes downstream will not function without them
- unless the genes function in a redundant manner
mesenchyme
Endochondral bone formation
First Phase
- mesenchyme (in sclerotome, _____) is induced to secrete Pax 1 and Scleraxis: activate cartilage specific genes
- transcription factors: promote transcription of other genes downstream
- have to be present, genes downstream will not function without them
- unless the genes function in a redundant manner
limbs
Endochondral bone formation
First Phase
- mesenchyme (in sclerotome, limbs) is induced to secrete _____ and Scleraxis: activate cartilage specific genes
- transcription factors: promote transcription of other genes downstream
- have to be present, genes downstream will not function without them
- unless the genes function in a redundant manner
Pax 1
Endochondral bone formation
First Phase
- mesenchyme (in sclerotome, limbs) is induced to secrete Pax 1 and _____ : activate cartilage specific genes
- transcription factors: promote transcription of other genes downstream
- have to be present, genes downstream will not function without them
- unless the genes function in a redundant manner
Scleraxis
Endochondral bone formation
First Phase
- mesenchyme (in sclerotome, limbs) is induced to secrete Pax 1 and Scleraxis: activate _____ _____ genes
- transcription factors: promote transcription of other genes downstream
- have to be present, genes downstream will not function without them
- unless the genes function in a redundant manner
cartilage specific
Endochondral bone formation
First Phase
- mesenchyme (in sclerotome, limbs) is induced to secrete Pax 1 and Scleraxis: activate cartilage specific genes
- ______ ______: promote transcription of other genes downstream
- have to be present, genes downstream will not function without them
- unless the genes function in a redundant manner
transcription factors
Endochondral bone formation
First Phase
- mesenchyme (in sclerotome, limbs) is induced to secrete Pax 1 and Scleraxis: activate cartilage specific genes
- transcription factors: promote transcription of other genes _________
- have to be present, genes downstream will not function without them
- unless the genes function in a redundant manner
downstream
Endochondral bone formation
First Phase
- mesenchyme (in sclerotome, limbs) is induced to secrete Pax 1 and Scleraxis: activate cartilage specific genes
- transcription factors: promote transcription of other genes downstream
- have to be ______, genes downstream will not function without them
- unless the genes function in a redundant manner
present
Endochondral bone formation
First Phase
- mesenchyme (in sclerotome, limbs) is induced to secrete Pax 1 and Scleraxis: activate cartilage specific genes
- transcription factors: promote transcription of other genes downstream
- have to be present, genes downstream will not function without them
- unless the genes function in a ________ manner
redundant
Endochondral Bone Formation
______ Phase
- committed mesenchyme cells condense into compact nodules and differentiate into chondrocytes
- N-cadherin - important in the initiation of these condensations, and N-CAM seems to be critical for maintaining them
Second
Endochondral Bone Formation
Second Phase
- ______ ______ _____ condense into compact nodules and differentiate into chondrocytes
- N-cadherin - important in the initiation of these condensations, and N-CAM seems to be critical for maintaining them
committed mesenchyme cells
Endochondral Bone Formation
Second Phase
- committed mesenchyme cells _____ into compact nodules and differentiate into chondrocytes
- N-cadherin - important in the initiation of these condensations, and N-CAM seems to be critical for maintaining them
condense
Endochondral Bone Formation
Second Phase
- committed mesenchyme cells condense into ______ ____and differentiate into chondrocytes
- N-cadherin - important in the initiation of these condensations, and N-CAM seems to be critical for maintaining them
compact nodules
Endochondral Bone Formation
Second Phase
- committed mesenchyme cells condense into compact nodules and ______ into chondrocytes
- N-cadherin - important in the initiation of these condensations, and N-CAM seems to be critical for maintaining them
differentiate
Endochondral Bone Formation
Second Phase
- committed mesenchyme cells condense into compact nodules and differentiate into ________
- N-cadherin - important in the initiation of these condensations, and N-CAM seems to be critical for maintaining them
chondrocytes
Endochondral Bone Formation
Second Phase
- committed mesenchyme cells condense into compact nodules and differentiate into chondrocytes
- _________ - important in the initiation of these condensations, and N-CAM seems to be critical for maintaining them
N-cadherin
Endochondral Bone Formation
Second Phase
- committed mesenchyme cells condense into compact nodules and differentiate into chondrocytes
- N-cadherin - important in the _______ of these condensations, and N-CAM seems to be critical for maintaining them
initiation
Endochondral Bone Formation
Second Phase
- committed mesenchyme cells condense into compact nodules and differentiate into chondrocytes
- N-cadherin - important in the initiation of these ___________, and N-CAM seems to be critical for maintaining them
condensations
Endochondral Bone Formation
Second Phase
- committed mesenchyme cells condense into compact nodules and differentiate into chondrocytes
- N-cadherin - important in the initiation of these condensations, and ______ seems to be critical for maintaining them
N-CAM
Endochondral Bone Formation
Second Phase
- committed mesenchyme cells condense into compact nodules and differentiate into chondrocytes
- N-cadherin - important in the initiation of these condensations, and N-CAM seems to be _______ for maintaining them
critical
Endochondral Bone Formation
Second Phase
- committed mesenchyme cells condense into compact nodules and differentiate into chondrocytes
- N-cadherin - important in the initiation of these condensations, and N-CAM seems to be critical for ______ them
maintaining
Endochondral Bone Formation
_____ _____
- the chondrocytes proliferate rapidly to form the model for the bone. As they divide, chondrocytes secrete a cartilage-specific extracellular matrix.
Third Phase
Endochondral Bone Formation
Third Phase
- the _______ proliferate rapidly to form the model for the bone. As they divide, chondrocytes secrete a cartilage-specific extracellular matrix.
chondrocytes
Endochondral Bone Formation
Third Phase
- the chondrocytes _______ rapidly to form the model for the bone. As they divide, chondrocytes secrete a cartilage-specific extracellular matrix.
proliferate
Endochondral Bone Formation
Third Phase
- the chondrocytes proliferate rapidly to form the _____ for the bone. As they divide, chondrocytes secrete a cartilage-specific extracellular matrix.
model
Endochondral Bone Formation
Third Phase
- the chondrocytes proliferate rapidly to form the model for the ____ . As they divide, chondrocytes secrete a cartilage-specific extracellular matrix.
bone
