Diuretics Flashcards
Carbonic anhydrase inhibitors example
Acetazolamide
CA inhibitor MOA
Acts on PCT
Inhibits CA to inhibit sodium + bicarb reabsorption
CA inhibitor clinical use
Mountain sickness
Glaucoma
CA inhibitor SEs
Metabolic acidosis
Bone marrow suspension
Loop diuretic example
Furosemide
Bumetanide
Loop diuretic MOA
Thick ascending loop of henle
Inhibits NaCl transporter to prevent Na+ absorption (also increases Ca2+ absorption)
Loop diuretic clinical use
Hypertension
Loop diuretic SEs
Hypokalaemia Hypercalcaemia Hyponatraemia Hyperglycaemia Hypercholesterolaemia Impotence
Potassium sparing diuretics
ENaC antagonists
Aldosterone antagonists
ENaC antagonist example
Amiloride
Triamterene
ENaC antagonist MOA
Distal DCT
Blocks ENaC to reduce sodium absorption
ENaC antagonist clinical use
HF
Hypokalaemia
Cirrhosis
ENaC SEs
Hyperkalaemia
Hyponatraemia
Aldosterone antagonists example
Spironolactone
Eplenerone
Aldosterone antagonist MOA
Distal DCT
Blocks Na/K ATPase to reduce drive in Na absorption through ENaC