Diuretics

Question 1

inhibits reabsorption of sodium and chloride in the distal renal tubules, increasing the excretion of sodium, chloride and water by the kidneys

Answer 1

MOA of Hydroclorothiazide

Question 2

adjunctive therapy for edema associated with HF, cirrhosis, corticosteroid or estrogen therapy, renal dysfunction, treatment for hypertension in conjunction with antihypertensices

Answer 2

Indications of Hydroclorothiazide

Question 3

dizziness, vertigo, orthostatic hypotension, nausea, anorexia, vomiting, dry mouth, diarrhea, polyuria, nocturia, muscle cramps, and spasms

Answer 3

Adverse effects of Hydroclorothiazide

Question 4

inhibits reabsorption of sodium and chloride from the distal tubules and loop of Henle, leading to sodium rich diuresis.

Answer 4

MOA of Furosemide – Lasix

Question 5

treatment for edema associated with HF, acute pulmonary edema, hypertension

Answer 5

Indications of Furosemide – Lasix

Question 6

dizziness, vertigo, paresthesia, orthostatic hypotension, rash, urticaria, nausea, anorexia, vomiting, glucosuria, urinary bladder spasm

Answer 6

Adverse effects of Furosemide – Lasix

Question 7

“potassium sparing diuretic” competitively blocks effects of aldosterone in the renal tubule, causing loss of sodium and water and retention of K

Answer 7

MOA of Spironolactone

Question 8

primary hyperaldosteronism, adjunctive therapy treatment of edema associated with HF, nephrotic syndrome, hepatic cirrhosis, hypokalemia, hypertension

Answer 8

Indications of Spironolactone

Question 9

dizziness, headache, drowsiness, rash, cramping, diarrhea, hyperkalemia, hirsutism, gynecomastia, deep voice, irregular menses

Answer 9

Adverse effects of Spironolactone