Diuretics

Question 1

Furosemide (Lasix)

Answer 1

Class: Loop diuretic

MOA: inhibits the reabsorption of sodium and chloride from the loop of Henle and distal renal tubule; increases the renal excretion of water, sodium, chloride, magnesium, potassium, and calcium

Pharmacokinetics: Onset –IV 5 min; duration- IV 2 hrs

Indications: edema due to heart failure; hypertension

AR/SE: dehydration, hypokalemia, hypovolemia, hypochloremia, hypomagnesemia, hyponatremia, metabolic alkalosis

Contraindications: known allergy, severe liver disease, diabetes

Dosage: 40 mg IV (or double pts daily dose up to 80 mg IV)