Cardiac Glycosides Flashcards
1
Q
Digoxin (lanoxin)
A
Class: inotropic, Cardiac glycoside
MOA: increased force of myocardial contraction, prolongs refractory period of AV node and decreases conduction through the SA and AV nodes
Pharmacokinetics: onset 5-30 min, duration 3-4 days; HL: 34-44 days
Indications: afib and aflutter to slow ventricular rate, atrial tachycardia
AR/SE: arrhythmias, fatigue, anorexia, N/V/D
Contraindications: known allergy, uncontrolled ventricular arrhythmias, aV block, constrictive pericarditis, pts showing signs of dig toxicity
Dosage: 0.25 mg slow IV every 2 hours up to a total loading dose of 1.5 mg (per physician order)
Special Considerations: (P class C) geriatric pt are very sensitive to toxic effects
