DIT Renal 4. Glomerular Pathology

Question 1

What are the defining features of nephritic syndrome?

Answer 1

Hematuria
RBC casts in urine
HTN
Mild proteinuria (<3.5 gm/day)
Azotemia
Oliguria

Question 7

Why is it important to treat Strep throat in children or in those that could transmit Strep pyogenes to a child?

Answer 7

to avoid Rheumatic fever

Question 10

What are the 3 glomerular disorders that use up C3 –>

Answer 10

1. poststreptococcal glomerulonephritis
2. lupus nephritis
3. type II membranoproliferative glomerulonephritis

Question 11

What is the defining features of nephrotic syndrome?

Answer 11

Marked proteinuria (> 3.5gm/day = frothy urine)
Hyperlipidemia
Fatty casts
Edema

Associated with increased risk of infection and thromboembolism

Question 12

granular pattern of immune complex deposition; LM: hypercellular glomeruli

Answer 12

acute post-strep glomerulonephritis

Question 15

linear pattern of immune complex deposition

Answer 15

Goodpasture Syndrome

Question 18

deposition of IgG, IgM, IgA, and C3 in the mesangium

Answer 18

IgA nephropathy (Berger’s disease)

Question 21

anti-GBM antibodies, hematuria, hemoptysis

Answer 21

Goodpasture syndrome

Question 24

nephritis, deafness, cataracts

Answer 24

Alport Syndrome

Question 26

A 4 yo boy presents with facial edema and proteinuria. What is the appropriate treatment?

Answer 26

minimal change disease

tx: corticosteroids

Question 27

crescent formation in the glomeruli

Answer 27

Rapid Proliferative (crescentic) Glomerulonephritis

Question 30

wire-loop apperance

Answer 30

SLE

Question 40

most common nephrotic syndrome in children

Answer 40

minimal change disease

Question 44

LM: diffuse capillary thickening

Answer 44

membranous glomerulonephritis

Question 47

Kimmelstiel-Wilson lesions (nodular glomerulosclerosis)

Answer 47

diabetic glomerulonephropathy

Question 50

most common nephrotic syndrome in adults

Answer 50

focal segmental glomerulosclerosis

Question 53

EM: loss of epithelial foot processes

Answer 53

minimal change disease

Question 56

Nephrotic syndrome associated with Hep B

Answer 56

type I membrano-proliferative glomerulonephritis

Question 59

Nephrotic syndrome associated with HIV

Answer 59

focal segmental glomerulosclerosis

Question 62

EM: subendothelial humps and tram-track appearance

Answer 62

Type I membrano-proliferative glomerulonephritis

Question 65

LM: segmental sclerosis and hyalinosis

Answer 65

focal segmental glomerulosclerosis

Question 68

purpura on back of arms and legs, abdominal pain, IgA nephropathy

Answer 68

Henoch-Schonlein Purpura

Question 71

apple-green birefringence with Congo-red stain under polarized light

Answer 71

Renal Amyloidosis

Question 74

EM: spiking of the GBM due to electron dense subepithelial deposits

Answer 74

type II membrano-proliferative glomerulonephritis

Question 75

Glomerular histology reveals multiple mesangial nodules. This lesion is indicative of what disease?

Answer 75

Diabetic Glomerulonephropathy

Question 76

A teenager presents with nephrotic syndrome and hearing loss. What is the disease?

Answer 76

Alport Syndrome