DISORDERS OF THE SCROTUM & TESTES Flashcards
CRYPTORCHIDISM
- What is it?
- Incidence is directly related to what? 2
- Undescended testes or absent testes (agenesis)
- Occurs when one or both of the testicles fail to move down into the scrotal sac. - Incidence is directly related to -birth weight and
- gestational age:
CRYPTORCHIDISM
- ___ of premature males
- The cause in full term infants is poorly understood - ____% of full term infants are born with undescended testicles:
Most cases are idiopathic
Some may be genetic or hormonal
- 1/3
2. 3-5
CRYPTORCHIDISM PATHOLOGY
1. Testes develop intra-abdominally in the fetus and usually descend into the scrotum through the___________ during the _________ month of gestation
- Undescended testicles remain where? 2
- inguinal canal, 7th to 9th
- in the lower abdomen or
- at a point of descent into the inguinal canal
CRYPTORCHIDISM PATHOLOGY
- The scrotal sac is what?
- The testis can be felt how? 2
- Spontaneous decent often occurs during when?
- By age what, the incidence decreases to 0.8%?
- Spontaneous decent rarely occurs after when?
- empty
- either is
- not palpable or
- can be felt external to the inguinal ring - first 3 months of life
- 6 months
- 6 months of age!
- Pathological changes to the undescended testicle can be demonstrated when?
- What are these patholoic changes? 3
- When the disorder is unilateral, it also may produce morphologic changes in what?
- at 6-12 months
- Delay in germ cell development
- Changes in the spermatic tubules
- Reduced number of Leydig cells
- contralateral descended testicle
CONSEQUENCES OF CRYPTORCHIDISM
4
- Infertility:
- Malignancy—risk is increased!!!
- Indirect inguinal hernias
- Increased incidence of testicular torsion
Why is infertility decreased in CRYPTORCHIDISM? 3
- Increases if disorder is bilateral
- Decreased sperm counts
- Poorer quality sperm
CRYPTORCHIDISM EXAM AND DIAGNOSIS
4
- Careful examination of genitalia in male infants
- Differentiate between undescended testes from retractable testes:
- Ultrasound occasionally
- Laparoscopy for diagnosis and treatment
Differentiate between undescended testes from retractable testes: How?
4
- Retract into the inguinal canal with cremasteric muscle reflex
- Are usually palpable at birth
- Careful palpation in warm room can bring them down
- Usually assume a scrotal position during puberty**
CRYPTORCHIDISM Treatment goals?
3
- Enhance future fertility potential
- Placement of the gonad in a favorable place for cancer detection
- Improved cosmetic appearance
CRYPTORCHIDISM
1. Orchiopexy should be considered after when, as the rate of descent diminishes considerably after this point?
2.What is it?
- 6 months of life
- Surgical placement and fixation of the testes in the scrotum
- 95% of orchiopexy patients will be fertile
CRYPTORCHIDISM Lifelong follow-up:
2
What should we educate about?
- Infertility issues
- Testicular cancer issues
**Upon reaching puberty, instruct boys in the necessity of testicular self-examination
This should be done monthly
HYDROCELE
1. What is it?
- Unilateral or bilateral?
- Usually due to?
- Excess fluid collects between the layers of the tunica vaginalis usually peritoneal fluid due to a weakness in the patent processus vaginalis**
- Can be both
- Due to a primary congenital defect or secondary condition
HYDROCELE Primary congenital: 1. Found in who? 2. Associated with what? 3. Prognosis? 4. When is surgical treatment indicated?
- Male infants and children
- Associated with indirect inguinal hernia
- Infant hydroceles usually close spontaneously
- If persists beyond 2 years of age, surgical treatment is indicated
HYDROCELE: Secondary causes?
7
- Trauma
- Epididymitis
- Testicular torsion
- Orchitis
- Infection
- Testicular cancer
- Appendiceal torsion
HYDROCELE
- On palpation feels how?
- Can be mistaken for what?
1 .Palpated as cystic mass(es)
Can become quite large
2. Mass can be mistaken for a solid tumor
HYDROCELE
Dx? 2
- Transillumination
2. US
HYDROCELE
1. Hydrocele develops in a young man without apparent cause: How should we
- In an adult male, hydrocele is a relatively benign condition
- Presents how?
- Feeling of heaviness where?
- Pain where?
- Hydrocele develops in a young man without apparent cause:
- It should be considered cancer until proven otherwise
- Careful evaluation is needed to exclude cancer or infection - In an adult male, hydrocele is a relatively benign condition:
- Is often asymptomatic
- Feeling of heaviness in the scrotum
- Pain in the lower back
HEMATOCELE
1. What is it?
- What can it cause?
- Etiologies? 4
- Accumulation of blood in the tunica vaginalis
- Can compromise testicle - Causes scrotal skin to become dark red or purple
- Etiologies:
- abdominal surgical procedure
- scrotal trauma
- bleeding disorder
- testicular tumor
SPERMATOCELE
- What is it?
- Located where?
- Attached where?
- Usually how big?
- Freely movable and should do what?
- How can they be problematic?
- Painless, sperm-containing cyst that forms on the epididymis
- Located above and posterior to the testes
- Attached to the epididymis
- Separate from the testes
- May be solitary or multiple - Usually greater than 2cm
- Freely movable and should transilluminate
- Rarely cause problems
If large, may become painful and require excision
VARICOCELE
- What is it?
- If condition is persistent, what happens? 2
- What is decreased in 65% to 74% of men? 2
- Rarely found when?
- Highest incidence is what ages?
- Varicosities of the pampiniform plexus:
- The network of veins that supplying the testes - If condition is persistent,
- damage to the elastic fibers and
- hypertrophy of the vein wall occurs (like varicose veins in the legs) - Sperm concentration and
- motility are decreased in 65% to 74% of men
- Rarely found before puberty
- Highest incidence is men between 15 and 35 years of age
VARICOCELE
LEFT SIDE MORE COMMON
1. Left gonadal vein inserts where?
- Right gonadal vein enters where?
- Incompetent valves are more common in the left, causing what?
- The force of gravity resulting from the upright position also contributes to what?
- in the left renal vein at a right angle.
- inferior vena cava.
- reflux of blood back into the veins of the pampiniform plexus.
- venous dilatation.
VARICOCELE SYMPTOMS/EXAM
-Can present how? 5
- Usually readily Dx how?
- Exam should be done with the pt in what position?
- The varicocele typically disappears how?
- Scrotal palpation will feel how?
- Can be asymptomatic.
- Dull aching,
- atrophy, and
- infertility
- An abnormal feeling of heaviness in the left when standing and relieved when recumbent
- Usually readily diagnosed on PE:
- Exam should be done with the patient in the standing and recumbent position.
- The varicocele typically disappears in the supine position
- Scrotal palpation will feel like “a bag of worms”
- VARICOCELE TREATMENT
3 - Who is this necessary in?
- Obliteration of the dilated veins. How? 3
- For those who are not needing increased fertility— how should we treat? 2
- Surgical ligation of the gonadal vein**
- Interventional radiology
- Embolization of veins
- Necessary in young males who are showing testicular atrophy**
- Some improvement in infertility
- Relief of the “heavy” feeling
- Cosmetic improvement
- NSAIDS & scrotal support
TESTICULAR TORSION
- What is it?
- Two peak ages?
- Acute urological emergency?
- Twisting of the spermatic cord that suspends the testis
- Two age peaks:
- Perinatal and prepubertal
- Presents between ages 10-25 - Acute urological emergency—viability of the testes is at risk
What is pathogonomic for torsion of appendix testes?
Blue dot sign (of dangerous appendix testis)
TESTICULAR TORSION Congenital, neonates: 1. Prevalence? 2. How will it look? 3. Color? 4. Swelling? 5. Rule out?
- Less common
- Firm, smooth, painless scrotal mass
- Scrotal skin appears red
- Some edema
- Physical exam and exclude the presence of a hernia
WONT TRANSILLUMINATE
TESTICULAR TORSION
Pediatrics and Adolescents:
1. Severity?
2. PP? 2
- Rarely seen after age___?
- What is essential?
- This is a true surgical emergency
- Testes rotates on the long axis of the tunica vaginalis, rotates about the distal spermatic cord
- Cuts off blood supply to the testis
- 30
- Early recognition and treatment are
Symptoms of testicular torsion?
7
Degree on swelling and redness depends on what?
- Patients present in severe distress within hours of onset
- Often accompanied with nausea and vomiting
- Tachycardia
- Large, firm and tender testes
- Pain radiates to inguinal area
- Testicle is often high in the scrotum and in abnormal orientation
- Cremasteric reflex is frequently absent
Degree of swelling and redness depends on the duration of the symptoms
- IMAGING: testicular torsion?
2. What is our referral window?
- Color Doppler ultrasonography must be done right away
- Referral to urology!!!!
4-6 hour window
TESTICULAR TORSION
1. Attempt _________, which can be attempted with pain relief as the guide for successful detorsion
- The procedure is similar to the “what” when the provider is standing at the patient’s feet?
- Most torsions twist inward and toward the mid line; thus, manual detorsion of the testicle involves twisting how?
- manual detorsion
- opening of a book
- outward and laterally.
If manual detorsion doesnt work:
- First option?
- Second?
- Surgical detorsion and fixation of the testicle (orchiopexy)
- Orchiectomy
- When is a Orchiectomy done?
- Salvage rates are directly related to what?
- What prophylatic measure is performed?
- Done when testis is deemed nonviable after surgical detorsion
- Salvage rates are directly related to the duration of the torsion
- Usually prophylactic fixation of the opposite testicle is performed!
What are the two major types of epididymitis?
- Sexually transmitted infections:
2. Primary non-sexually transmitted infections
Sexually transmitted infections:
- Associated with what? 2
- Bugs? 2
Primary non-sexually transmitted infections
- Associated with what? 3
- Bugs? 3
Other causes? 2
Sexually transmitted infections:
- Associated with urethritis
- Associated with young men
- N. Neisseria gonorrhea
- Chlamydia trachomatis
Primary non-sexually transmitted infections:
- Associated with UTI’s and
- Prostatitis
- Associated with men over 35
- E-coli
- Pseudomonas
- Gram-positive cocci
-Post vasectomy
-Trauma
*****Most cases of epididymitis are caused by
bacterial pathogens.
EPIDIDYMITIS
- What is it?
- Can also experience reactive hydrocele. How will this present?
- Symptoms? 4
- Unilateral pain and swelling in the epididymis over a period of days
- Erythema and edema of the overlying scrotal skin Can become extremely large (reactive hydrocoele)
- Tenderness over the groin or in the lower abdomen
- Fever
- Dysuria
- Could have urethral discharge if gonococcal
EPIDIDYMITIS LABS
4
- CBC
- Urinalysis and culture
- Urethral culture (or urine NAAT)
- Gram stain
EPIDIDYMITIS TREATMENT
4
- Scrotal elevation and support
- Antibiotics appropriate to age, physical findings, urinalysis, cultures or gram’s stain, sexual history
- Oral analgesics and antipyretics
- Sexual activity or physical strain should be avoided until symptoms resolve
HYPOGONADISM
Definition?
Etiologies? 5
- Definition:
- Testosterone deficiency with associated symptoms or signs, deficiency of spermatozoa production, or both
- Either primary or secondary
Etiology
- Primary hypogonadism
- Failure of testes to respond to FSH and LH
- Testosterone is low to inhibit production of FSH and LH
- Most common cause is Klinefelters Syndrome
Secondary hypogonadism
5. Failure of hypothalamus to produce gonadotropin-releasing hormone (GnRH) or pituitary gland to produce enough FSH and LH
Signs and Symptoms 3 categories 1. Congenital hypogonadism? 2 2. Childhood-onset? 1 3. Adult-onset? 3
Congenital hypogonadism
- 1st trimester- Results in inadequate male sexual differentiation
- 2nd or 3rd trimester- Results in microphallus and undescended testes
Childhood-onset
-Impairs development of secondary sexual characteristics
- Adult-onset
- Decreased libido
- ED
- Depression and anger
How will childhood onset hypogonadism affect them as adults?
5
As adults have:
- Poor muscle development
- High-pitched voice
- Small scrotum
- Decreased penis and testicular growth
- Sparse pubic and axillary hair
HYPOGONADISM
Dx? 3
Treatment? 1
Adverse affects? 5
1. Diagnosis Begin with; -FSH -LH -Free/Total testosterone levels
- Treatment
-Testosterone replacement therapy (TRT)
Gel 1% or 1.62%
Transdermal axillary solution
Transdermal patch
Sub-Q implants
IM injections (cheapest) - Adverse effects
- Erythrocytosis
- Venous thromboembolism
- Acne
- Gynecomastia
- Low sperm counts
INFERTILITY
- What is this?
- Causes? 4
- Male factors? 3
- Inability to get pregnant after trying for at least 1 year
- About one-third of cases are caused by male factor - Causes:
- Blockage of the reproductive system
- Medicines
- Undescended testicles
- Infections - Male factors
- Pretesticular
- Testicular
- posttesticular
INFERTILITY
1. Ask about medical history
Such as?4
- Physical Exam? 6
- Previous semen analysis
- ED or other sexual dysfunction
- Trauma
- Previous pregnancies
- Testicular size
- Vas deferens
- Spermatic cord
- Penis
- Rectum
- Body habitus
INFERTILITY
Dx?
5
- Semen analysis
- Antisperm antibody test
- Hormonal analysis
- Transrectal ultrasound
- Scrotal ultrasound
Semen analysis looks at what?
4
1. Semen volume 2-5ml pH level 7.2-7.8 2. Sperm density >20 million 3. Motility 50% forward progessive 4. Morphology >60% normal (
INFERTILITY
Tx?
- Boxer shorts
- Avoid hot tubs
- Timing of intercourse
- Avoid illegal drugs, chemicals, and spermicidals
- Medications
- Surgical
Infertility meds? 3
Surgica options? 4
- Medications
- Clomiphene citrate (Clomid)
- Imipramine
- Zoloft - Surgical
- Varicocelectomy
- Vasovasostomy
- Testicular biopsy (TESE)
- Transurethral resection of ejaculatory ducts