Disorders of Synapses

Question 1

Myasthenia Gravis:

Answer 1

AI disorder with Abs against AcH receptor in NMJ —> no AcH binding

Question 2

Botulinum:

Answer 2

types A/E cleave SNAP25, type C cleaves syntaxin and types B,D,F,G cleave synaptobrevin –> ↓AcH
–> paralysis

Question 3

Tetanus:

Answer 3

cleaves synaptobrevin selectively targeting GABAergic synaptic transmission –> no inhibitory signal –> tetanus

Question 4

Multiple Sclerosis ~

Answer 4

AI Demyelination Disorder in Young Adults —> Neurodegeneration (↓axons) + Demyelination (white on MRI)