Disorders Of Renal Failure & Kidney—USE** Flashcards
Kidney Funtions
Regulate electrolytes
Eliminate wastes
Filter blood
Regulate fluid volume & blood pressure
Secrete erythropoietin
Metabolize vitamin D
Maintain bone calcification
Renal Failure
Inability of nephrons to maintain:
Fluid, electrolyte, and acid-base balance
Excretion of nitrogenous waste
Regulatory functions (erythropoietin production)
Types:
Acute Kidney Injury (AKI)
Chronic Kidney Disease (CKD)
Acute Kidney Injury (AKI)
Sudden, rapid decrease in renal function
Potentially reversible with early treatment
Causes: Prerenal (decreases blood flow); Intrarenal (tissue damage); Postrenal (obstruction)
Pathophysiology: decreases GFR —> oliguria, increases BUN & creatinine —> waste buildup
Phase of AKI: Onset, oliguric (anuric), diuretic, recovery
Chronic Kidney Disease (CKD)
Progressive & irreversible kidney damage
Top causes: diabetes, hypertension, glomerulonephritis
Stages: 1 —> 5
Clinical features: decreased urine output, azotemia, uremia, uremic frost, proteinuria, edema, hypertension, hyponatremia (diluted sodium, anemia, SOB
Electrolytes Imbalance: hyperkalemia, hyperphosphatemia, hypermagnesemia, hypocalcemia, metabolic acidosis
Dialysis
Purpose: Clean and filter blood
Semipermeable membrane
Diffusion, osmosis, filtration, ultrafiltration
Dialysate creates concentration gradient
Hemodialysis
AV fistula/graft (feel for thrill, listen for bruit)
Central/femoral catheter access
Nursing management:
-Monitor for: SOB, hypotension, N/V, tachycardia, muscle cramps, Dysrhythmias, disequilibrium syndrome, bleeding risk (client is heparinized)
Peritoneal dialysis
Uses peritoneum as filter
CAPD: 3-5 exchange/day
APD: machine at night
Nursing Management:
Monitor for peritonitis (major complication)
Weight client regularly
Watch for: N/V, abdmonial pain, rigidity, tenderness
Kidney Transplant
Complications:
Rejection
Hemorrhage
Renal artery thrombosis
Infection
Antirejection drugs necessary
Polycystic Kidney Disease (PKD)
*Hereditary; Multiple bilateral kidney cysts —> interfere with function —> renal failure
Assessment findings: HTN, lumbar/abdominal pain, tenderness, colic, Hematuria, renal stones, headaches, increased abdominal girth
Diagnostics: UA: proteinuria, Hematuria, pyuria, CBC (decreased) or RBC (elevated), enlarged kidneys, BUN & creatinine (elevated)
Treatment:
HTN: antihypertensives, diuretics, sodium restriction
UTI: antibiotics
Anemia: iron, erythropoietin (Epogen)
Acute Glomerulonephritis
Inflammation of glomeruli; often post-infectious (bacterial/viral); permeability (increased), RBCs/protein leak into urine
Symptoms: often asymptomatic; fever, nausea, malaise, HA, edema (periorbital, generalized); Hematuria (cola-colored), proteinuria (foamy urine); HTN, fatigue; pain over kidneys, nocturnal, SOB, anemia, CHR, oliguria/anuria
Diagnostics: Hematuria, proteinuria, antistreptolysin O (ASO) tiger (elevated), Hgb (decreased); slight (increased) BUN & creatinine; ESR (elevated); If renal insufficiency: hyperkalemia, hypermagnesemia, hypocalcemia, dilutional hyponatremia
NOTE specific treatment
Chronic Glomerulonephritis
Slow progression —> irreversible nephron damage; third leading cause of end-stage kidney disease
Symptoms: sometimes asymptomatic, Anasarca, fatigue, HA, dizziness, HTN, dyspnea, visual disturbances, weight loss, GI issues, decreased strength, nocturia
Diagnostics: RBCs (decreased); Azotemia; BUN, creatinine, uric acid (all elevated); hyperkalemia; phosphorus (increased); calcium (decreased); chest X-ray will show cardiac enlargement; ECG: LVH, tall peaked T waves
Pyelonephritis
Acute or Chronic: infection of kidneys and collecting system
Acute: kidney enlargement, inflammation; later fibrosis/scarring
Chronic: after repeated acute infections
Symptoms: flank pain; fever; chills; malaise; cloudy; bloody, foul-smelling urine; polyuria; nocturia; chronic cases may have vague GI complaints or be asymptomatic
Diagnostics: urine culture; VCUG; KUB x-ray; DMSA scan; BUN & creatinine
Treatment: Antibiotics: ciprofloxacin, sulfamethoxazole/Trimethoprim; ceftriaxone; Gentamicin—Nephrectomy (if severe HTN & other kidney is functional)
What medication is used to treat anemia in chronic kidney disease?
Erythropoietin (Epogen)
What class of medications is used to manage hypertension in kidney disease?
Antihypertensives (ACE inhibitors, ARBs)
What medication type is often used alongside antihypertensives to manage fluid volume in polycystic kidney disease?
Diuretics
What is given along with erythropoietin to support RBC production in kidney disease?
Iron supplements
Name antibiotics used to treat pyelonephritis
Ciprofloxacin, Sulfamethoxazole/Trimethoprim (Bactrim), Ceftriaxone, Gentamicin
Why must you monitor Gentamicin levels in patients with kidney impairment?
Risk of nephrotoxicity & ototoxicity
What is used to prevent transplant rejection after kidney transplant?
Antirejection drugs (corticosteroids, calcineurin inhibitors)
What must you monitor closely in patients receiving hemodialysis & heparin?
Signs of bleeding due to anticoagulation
What is a key medication-related complication of peritoneal dialysis?
Peritonitis—requires prompt antibiotic treatment
What are the three causes of acute kidney injury?
Prerenal (decreased blood flow); Intrarenal (tissue damage); postrenal (obstruction)
What are the four phases of acute kidney injury?
Onset, Oliguric, Diuretic, Recovery