Disorders of Hemostasis - Green Flashcards
Which species get coagulopathies more frequently?
Dogs > cats
What is the most common bleeding disorder?
ITP
(Immune Mediated Thrombocytopenia)
What is the most common spontaneous bleeding disorder in DOGS?
Thrombocytopenia
Is DIC a primary disease?
NO!
It’s the end result of an inflammatory process that causes consumption of platelets & coagulation factors
vWD _______ causes spontaneous bleeding.
Rarely
Characteristics of the Primary hemostatic plug.
- Short-lived (secs)
- Unstable
- Forms the framework 2° hemostasis
- Platelets (deficiencies or malfxn)
What is the mediator of Secondary Hemostasis?
Clotting Factors
Which clotting factor has the shortest t1/2 of all the coagulation factors?
Factor VII
Which factors are involved in the Intrinsic Pathway?
“Not $12. It’s $11.98!”
- Factors 12, 11, 9 & 8
What factors are involved in the Extrinsic Pathway?
Factors 3 & 7
What DX test looks at the Extrinsic Pathway?
OSPT
1° Hemostatic defects cause _________ or ________.
Platelet or vascular disorders
2° Hemostatic defects cause _______________.
Clotting factor deficiencies
C/S of 1° Hemostatic Defects?
- Petechia, ecchymoses
- Melena
- Hematuria
- Hematochezia
- Epistaxis
- Prolonged bleeding time after venipuncture
What is the most common cause of 1° Hemostatic Defects?
Thrombocytopenia
What is the most common Thrombocytopathia?
vWD
C/S of 2° Hemostatic Defects?
- Deep bleeding (big bleeds)
- Hemoabdomen
- Hemothorax
- Deep hematomas