Disorders of Hemostasis

Question 1

-Autoimmune disorder in which antibodies bind platelets , inactivating
-Primarily idiopathic
Dx: Thrombocytopenia–>Diagnosis of exclusion

Answer 1

Immune/Idiopathic Thrombocytopenia Purpura

Question 2

• Thrombocytopenia due to incorporation of platelets into thrombi in microvasculature
• Idiopathic

Answer 2

Thrombotic Thrombocytopenia Purpura (TTP)

Question 3

• Triad of concurrent microangiopathic hemolytic anemia (hemolysis due to small vessel thrombi), thrombocytopenia and acute kidney injury
• Mostly seen in children
• Most often preceded my hemorrhagic enteritis

Answer 3

Hemolytic Uremic Syndrome

Question 4

• Small vessel vasculitis–>thought due to immune complex deposition
• More common in children
• Often assoc. with inflammatory arthritis

Answer 4

Henoch-Schönlein Purpura

Question 5

-Antibody formation to platelet-heparin factor

Answer 5

Heparin-Induced Thrombocytopenia (HIT)