Disorders Affecting White Blood Cells

Question 1

Chédiak-Higashi Syndrome

Answer 1

Inherited (autosomal recessive) disorder causing many large, greenish primary cytoplasmic granules or many
large, reddish-purple secondary cytoplasmic granules. Can cause complete or partial albinism and is usually
fatal.

Question 2

Chronic Granulomatous Disease

Answer 2

• Etiology: caused by inability of phagocytes to produce superoxide and reactive oxygen species. Formation of
  granulomas during chronic inflammatory reactions. Patients normally have a history of recurrent infections.
• Laboratory Diagnosis:
  o Neutrophilia
  o Increased WBC count
  o Nitroblue tetrazolium reduction test negative