Coagulation

Question 1

Process of Hemostasis

Answer 1

1) Constriction of the blood vessel.
2) Formation of a temporary “platelet plug.”
3) Activation of the coagulation cascade.
4) Formation of “fibrin plug” or the final clot.

Question 2

Primary Hemostasis

Answer 2

Vasocontraction
Platelet adhesion
PlateletSe aggregation to form primary hemostatic plug at injury site

Question 3

Secondary Hemostasis

Answer 3

-Interaction of Coag Factors to produce fibrin (secondary hemostatic plug)
-Fibrin stabilization by Factor 13

Question 4

Fibrinolysis

Answer 4

-Release of tissue plasminogen activator
-Conversion of plasminogen to plasmin
-Conversion of fibrin-fibrin degradation products

Question 5

Factor I

Answer 5

Fibrinogen (I, E, C)
Converts to fibrin by thrombin

Question 6

Factor II

Answer 6

Prothrombin (I, E, C)
Precursor of thrombin

Question 7

Factor III

Answer 7

Tissue Factor (E)
Phospholipid released from injured vessel wall, not normally in blood

Question 8

Factor IV

Answer 8

Calcium Ions Ca2= (I, E, C)
Bound by anticoagulant sodium citrate.

Question 9

Factor V

Answer 9

Liable Factor (I, E, C)

Question 10

Factor VII

Answer 10

Stable Factor (E)

Question 11

Factor VIII

Answer 11

Antihemophilic Factor (I)
Critical in Hemophilia A deficiency
Circulates in association with VWF. VWF stabilizes VIII prolonging half life. VIII:C = Coagulant portion.

Question 12

Factor IX

Answer 12

Christmas Factor (plasma thromboplastin component) (I)
Critical in hemophilia B deficiency

Question 13

Factor X

Answer 13

Stuart Factor (I , E, C)

Question 14

Factor XI

Answer 14

Plasma thromboplastin antecedent (I)
Rare but critical in hemophilia C

Question 15

Factor XII

Answer 15

Hegeman Factor (I)

Question 16

Factor XIII

Answer 16

Fibrin stabilizing factor ( I, E, C)
Stabilizes fibrin clot

Question 17

HMWK

Answer 17

High molecular weight kiniogen (I)
Non part of the in vivo coagulation

Question 18

PK

Answer 18

Prekallikrein (Fletcher factor) (I)
Not part of in vivo coagulation

Question 19

Contact Group

Answer 19

PK, HMWK, XII, XI
Involved in initiation of intrinsic pathway

Question 20

Prothrombin Group

Answer 20

II, VII, IX, X
Vitamin K-Dependent Factors

Question 21

Fibrinogen Group

Answer 21

I, V, VIII, XIII
Factors acted on by thrombin (V, VII & XIII are activated; I is converted to fibrin)

Question 22

Factors in extrinsic pathway

Answer 22

TF, VII

Question 23

Factors in intrinsic pathway

Answer 23

PK, HMWK, XII,XI, IX, VIII

Question 24

Factors in the common pathwau

Answer 24

X, V, II, I

Question 25

extrinsic tenase complex

Answer 25

VIIa/TF Acts on X

Question 26

Intrinsic tenase complex

Answer 26

IXa/VIIIa Acts on X

Question 27

Prothombinase complex

Answer 27

Xa/Va Acts on prothrombin

Question 28

Factor VIII complex

Answer 28

VIII:C and von willebreand factor VIII:C is the procoagulant, VWF is the carrier rotein

Question 29

Where are all the factors produced?

Answer 29

In the liver

Question 30

Requires Vitamin K for synthesis

Answer 30

II, VII, IX, X

Question 31

Affected by the anticoagulant therapy (Coumadin)

Answer 31

II, VII, IX, X All the require Vitamin K, warfarin is an vitamin K antagonist

Question 32

Consumed during clotting

Answer 32

I, II, V, VIII, XIIII Not present in serum

Question 33

Labile Factors

Answer 33

V, VIII