Diseases of the Pleura Flashcards

1
Q

What is a pleural effusion?

When can it be detected on CXR? And clinically?

A
  • Pleural effusion is an excessive accumulation of fluid in the pleural space.
  • It can be detected on X-Ray when ≥300mL of fluid is present, and clinically, when ≥500mL is present.
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2
Q

Describe the appearance of a pleural effusion on CXR.

A
  • The CXR appearances range from obliteration of the costophrenic angle to dense homologous shadows occupying part or all of the hemithorax.
  • Fluid below the lung (a subpulmonary effusion) can stimulate a raised hemidiaphragm.
  • Fluid in the fissures may resemble an intrapulmonary mass.
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3
Q

Define transudate.

A
  • Effusions that are transudates can be bilateral but are often larger on the right.
  • The protein content is <30g/L, the lactate dehydrogenase (LDH) is <200IU/L and the fluid to serum ratio is <0.6.
  • Transudates are watery.
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4
Q

What are the causes of transudates?

A
  • Heart failure
  • Hypoproteinaemia (e.g. nephrotic syndrome)
  • Constrictive pericarditis
  • Hypothyroidism
  • Ovarian tumours producing right-sided pleural effusion – Meigs syndrome
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5
Q

Define exudate.

A
  • The protein content of exudates is >30g/L and the LDH is >200IU/L.
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6
Q

What are the causes of exudates?

A
  • Bacterial pneumonia
  • Carcinoma of the bronchus and pulmonary infarction – fluid may be blood-stained
  • TB
  • Autoimmune rheumatic diseases
  • Post-MI syndrome
  • Acute pancreatitis
  • Mesothelioma
  • Sarcoidosis
  • Yellow-nail syndrome (effusion due to lymphoedema)
  • Familial Mediterranean fever
  • Exudates are thick and pusy.
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7
Q

What is Light’s criteria?

A
  • Criteria to distinguish between exudative effusion and transudative effusion.
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8
Q

Describe the diagnosis of pleural effusion.

A
  • Diagnosis is by pleural aspiration, usually done with ultrasound guidance.
  • This is necessary for all but very small effusions.
  • A needle is inserted under local anaesthetic through an intercostal space towards the top of the area identified on USS.
  • Fluid is withdrawn and the presence of any blood is noted.
  • Samples are sent for cytology, protein estimation, LDH and bacteriological examination, including culture and Ziehl-Neelsen / auramine staining for TB.
  • Large amounts of fluid can be aspirated through a large-bore needle to help relieve extreme breathlessness.
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9
Q

What is a pneumothorax?

What are the 2 types?

A
  • Pneumothorax is air in the pleural space.
  • Either spontaneous or post-trauma to the chest.
    • Spontaneous pneumothorax most common in young males (male:female 6:1); often they are tall and thin.
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10
Q

What is the cause of spontaneous pneumothorax?

A
  • Spontaneous pneumothorax is caused by the rupture of a pleural bleb, usually apical, and is thought to be due to congenital defects in the connective tissue of the alveolar walls.
  • In patients >40, the usual cause is COPD.
  • Rarer causes include bronchial asthma, carcinoma, breakdown of a lung abscess leading to bronchopleural fistula, and severe pulmonary fibrosis with cyst formation.
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11
Q

What causes a pneumothorax to be localised or generalised?

A
  • Pneumothorax may be localised if the visceral pleura has previously become adherent to the parietal pleura, or generalised if there are no pleural adhesions.
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12
Q

How does a bronchopleural fistula develop?

A
  • Normally, the pressure in the pleural space is negative but this is lost once a communication is made with atmospheric pressure; the elastic recoil pressure of the lung then causes it to deflate partially.
  • If the communication between the airways and the pleural space remains open, a bronchopleural fistula results.
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13
Q

How long does it take for a pneumothorax to resolve?

A
  • Once the communication between the lung and the pleural space is closed, air will be reabsorbed at a rate of 1.25% of the total radiographic volume of the hemithorax per day.
  • Thus, a 50% collapse of the lung will take ~40 days to reabsorb completely once the air leak is closed.
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14
Q

What is a tension pneumothorax?

A
  • It has been postulated that a valvular mechanism may develop through which are can be sucked into the pleural space during inspiration but not expelled during expiration.
  • The intrapleural pressure remains positive throughout breathing, the lung deflates further, the mediastinum shifts, and venous return to the heart decreases, with increasing respiratory and cardiac embarrassment.
  • This is tension pneumothorax, and is very rare, except in patients on positive pressure ventilation.
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15
Q

Outline the presentation and evaluation of suspected pneumothorax.

A
  • The usual presenting features are sudden onset of unilateral pleuritic pain or progressively increasing breathlessness.
  • If the pneumothorax enlarges, the patient becomes more breathless and may develop pallor and tachycardia.
  • There may be few physical signs if the pneumothorax is small.
  • Evaluated using CXR.
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16
Q

Outline the treatment options for pneumothorax.

A