Diseases of the Pleura Flashcards
1
Q
What is a pleural effusion?
When can it be detected on CXR? And clinically?
A
- Pleural effusion is an excessive accumulation of fluid in the pleural space.
- It can be detected on X-Ray when ≥300mL of fluid is present, and clinically, when ≥500mL is present.
2
Q
Describe the appearance of a pleural effusion on CXR.
A
- The CXR appearances range from obliteration of the costophrenic angle to dense homologous shadows occupying part or all of the hemithorax.
- Fluid below the lung (a subpulmonary effusion) can stimulate a raised hemidiaphragm.
- Fluid in the fissures may resemble an intrapulmonary mass.
3
Q
Define transudate.
A
- Effusions that are transudates can be bilateral but are often larger on the right.
- The protein content is <30g/L, the lactate dehydrogenase (LDH) is <200IU/L and the fluid to serum ratio is <0.6.
- Transudates are watery.
4
Q
What are the causes of transudates?
A
- Heart failure
- Hypoproteinaemia (e.g. nephrotic syndrome)
- Constrictive pericarditis
- Hypothyroidism
- Ovarian tumours producing right-sided pleural effusion – Meigs syndrome
5
Q
Define exudate.
A
- The protein content of exudates is >30g/L and the LDH is >200IU/L.
6
Q
What are the causes of exudates?
A
- Bacterial pneumonia
- Carcinoma of the bronchus and pulmonary infarction – fluid may be blood-stained
- TB
- Autoimmune rheumatic diseases
- Post-MI syndrome
- Acute pancreatitis
- Mesothelioma
- Sarcoidosis
- Yellow-nail syndrome (effusion due to lymphoedema)
- Familial Mediterranean fever
- Exudates are thick and pusy.
7
Q
What is Light’s criteria?
A
- Criteria to distinguish between exudative effusion and transudative effusion.
8
Q
Describe the diagnosis of pleural effusion.
A
- Diagnosis is by pleural aspiration, usually done with ultrasound guidance.
- This is necessary for all but very small effusions.
- A needle is inserted under local anaesthetic through an intercostal space towards the top of the area identified on USS.
- Fluid is withdrawn and the presence of any blood is noted.
- Samples are sent for cytology, protein estimation, LDH and bacteriological examination, including culture and Ziehl-Neelsen / auramine staining for TB.
- Large amounts of fluid can be aspirated through a large-bore needle to help relieve extreme breathlessness.
9
Q
What is a pneumothorax?
What are the 2 types?
A
- Pneumothorax is air in the pleural space.
- Either spontaneous or post-trauma to the chest.
- Spontaneous pneumothorax most common in young males (male:female 6:1); often they are tall and thin.
10
Q
What is the cause of spontaneous pneumothorax?
A
- Spontaneous pneumothorax is caused by the rupture of a pleural bleb, usually apical, and is thought to be due to congenital defects in the connective tissue of the alveolar walls.
- In patients >40, the usual cause is COPD.
- Rarer causes include bronchial asthma, carcinoma, breakdown of a lung abscess leading to bronchopleural fistula, and severe pulmonary fibrosis with cyst formation.
11
Q
What causes a pneumothorax to be localised or generalised?
A
- Pneumothorax may be localised if the visceral pleura has previously become adherent to the parietal pleura, or generalised if there are no pleural adhesions.
12
Q
How does a bronchopleural fistula develop?
A
- Normally, the pressure in the pleural space is negative but this is lost once a communication is made with atmospheric pressure; the elastic recoil pressure of the lung then causes it to deflate partially.
- If the communication between the airways and the pleural space remains open, a bronchopleural fistula results.
13
Q
How long does it take for a pneumothorax to resolve?
A
- Once the communication between the lung and the pleural space is closed, air will be reabsorbed at a rate of 1.25% of the total radiographic volume of the hemithorax per day.
- Thus, a 50% collapse of the lung will take ~40 days to reabsorb completely once the air leak is closed.
14
Q
What is a tension pneumothorax?
A
- It has been postulated that a valvular mechanism may develop through which are can be sucked into the pleural space during inspiration but not expelled during expiration.
- The intrapleural pressure remains positive throughout breathing, the lung deflates further, the mediastinum shifts, and venous return to the heart decreases, with increasing respiratory and cardiac embarrassment.
- This is tension pneumothorax, and is very rare, except in patients on positive pressure ventilation.
15
Q
Outline the presentation and evaluation of suspected pneumothorax.
A
- The usual presenting features are sudden onset of unilateral pleuritic pain or progressively increasing breathlessness.
- If the pneumothorax enlarges, the patient becomes more breathless and may develop pallor and tachycardia.
- There may be few physical signs if the pneumothorax is small.
- Evaluated using CXR.