diseases of oral mucosa

Question 1

draw the classification of oral mucosa lesions according to clinical appearance

Answer 1

Question 2

what ulcers are associated iSight viral infections

Answer 2

multiple ulcers

Question 3

what are white lesions usually NOT caused by

Answer 3

no viral or immunological fungal cause

Question 4

what re infective and non infective lesions caused by

Answer 4

infective
- viral and fungi and bacteria
non infecitve- reaction/truama/ immunological,cancerous

Question 5

descrive herpes simplex

Answer 5

multiple vesicles that burst in ucler
0 infective viral lesion
- most common virus
- coldsore on lips

Question 6

describe the pathology of herpes simplex

Answer 6

• Lymphtocyes invade oral epitehlium causing inflammation
• intraepithelial vesicle formed of fluid
• when vesicle reaches certain size it bursts to produce ulcer

Question 7

how is herpes simplex diagnosed

Answer 7

Diagnosed by swab
Intracellular inclusion bodies- viral bodies present

Question 8

Describe oral thrush

Answer 8

• candida
  affect newly born children or old people -

Question 9

who does oral thrush affect

Answer 9

• newly born children or elderly people
• immunosuppressant due to high dose of anitbitoaitcs

Question 10

what are the clinical symptoms of oral thrush

Answer 10

tongue, throat , white lesion
when you remove it , it will leave a raw bleeding surface

Question 11

describe the pathology of candida

Answer 11

• candida hype penetrate eptiehul layer
• intrapeitehial abscess formed due to degeneration of epitehoul layer due to infection
  infllamtry infiltration of lymphocytes underneath
• disrupts plate and affect wall tissues

Question 12

name 3 types of non infective ulcers

Answer 12

aphthous ulcer
traumatic ucler
squamous cell carnoam

Question 13

what is the cause of recurrent authors ulcer

Answer 13

unknown cause, stress, Crohns disease, nutritional deficiencies such as vitamin B deficiencies

Question 14

what is the cause of traumatic ulcers

Answer 14

aused by dentist ,LA, rare , heal within 10 days to 2 weeks- well defined but ragged border
Both have loss of surface epithelial and inflammation in lamina propria or connectivity tissues

Question 15

what is the symptoms and cause of malignant ulcers

Answer 15

non healing ulcer , inflammation- underlying
Basement membrane is ruptured
epithelial islands that have grown into the connective tissue - sign of cancerous lesions

Question 16

what non infective ulcer does this show

Answer 16

apthourse and traumatic ulcer
- loss of surface epithelial and inflammation in lamina propria

Question 17

what non infective ulcer does this image show

Answer 17

squamous cell carcinoma

Question 18

name some white an d red lesions

Answer 18

Question 19

what is dysplasia

Answer 19

away form normal shape and size

Question 20

what is hyperplasia

Answer 20

overgrowth of epithelium

Question 21

what is acanthosis -

Answer 21

growth of prickle cell layer

Question 22

what Is hyperkeratosis

Answer 22

• whiteness - keratin block epithelial - overkertainisaiton - white leison
  Protective measure

Question 23

what feature is only present in white cell lesions

Answer 23

hyperkeratosis

Question 24

dsiitngusih between histopahtoglogy

Answer 24

Question 25

name 3 immunoligcla lesions

Answer 25

Question 26

describe lcihen plants

Answer 26

LICHEN PLANUS - t lymphocyte mediated inflammatory disease - CD4 and CD8 most common cells - Lichenoid caused by drugs but not lichen planus - 65% females above 40 White strain on surface of mucosa Small ulcers Sometimes in form of plaque To differentiate from others - the lichen planus happens laterally on buccal mucosa and on doral of tongue and rarely in gingiva Respond clinically to corticosteroids PATHOLOGICALLY THEY HAVE - very well known appearance Rete pegs are narrowed in form of saw Saw tooth tapered at end Characterised by thin band of lymphocytes - t lymphocytes and CD8 White lesions characterised by hyperkeratosiss na dlymphocytic ifnirliatiosn If lesion is atrophic - flattening epithelium and no rete pegs and destruction of basal cell layer and smaller band of infiltration aouion band It is a premalignant lesion which can turn malignant

Question 27

describe pathology of lichen planus

Answer 27

PATHOLOGICALLY THEY HAVE - very well known appearance Rete pegs are narrowed in form of saw Saw tooth tapered at end Characterised by thin band of lymphocytes - t lymphocytes and CD8 White lesions characterised by hyperkeratosiss na dlymphocytic ifnirliatiosn If lesion is atrophic - flattening epithelium and no rete pegs and destruction of basal cell layer and smaller band of infiltration aouion band It is a premalignant lesion which can turn malignant

Question 29

describe systemic lupus

Answer 29

mmunologicla /autoimmune disease connected to RA or liver Only skin and oral mucosa are affected Similar to lichen planus Orla lesions present in 20% of the cases Preceded by other manifestations first Differentiating factor Unilateral Lesions cna be white or red or ulceraitve 30% of cases sjdroegn syndrome is associated or developed - affects salivary glands Irregular e;epithelium atrophy Some inflammatory infiltrations

Question 30

describe the pathology of lupus

Answer 30

Thickening of BM, inflammatory infiltration band, degeneration of the epithelial cells

Question 31

describer erythema multiform

Answer 31

necrosis of prickle cell layer leading to intra epithelial bulla - no Clea cruise - 3-4 weeks with more lesion developing - recurrent in month and years - associated with ocular lesion - lead to loss of site

Question 32

list two immunological disorders

Answer 32

Question 33

describe the histopathology of pemphigus vulgars

Answer 33

- - Form vesicles that have clear fluid and bulla with clear vesicles - - Immunological - antibodies against substance Call quill detach from each other due to attack of intracellular semantic substance called acantholysis - prickle cell layer will loose connection with each other and form intraepithelial vesicles above the basal cell layer layer forming bulla Forging clefting above the basal cell layer forming intraepithelial vesicles that can lead to ulcers, acantholysis of the prickle cell layer ( loss of intercellular adherence), inflammatory infiltration in the underlying c.t. Binding antibodies to cells can be seen by fluorescence