DISEASES OF INFANCY AND CHILDHOOD Flashcards
What are Childhood disease?
Childhood disease in the perinatal period are associated with significant morbidity and mortality.
A variety of different errors can affect the process of morphogenesis
Malformation: primary error involving intrinsic abnormal development process such as CHD, anenceephaly.
Disruption: Due to secondary destruction of a normal tissue arising from extrinsic disturbance in morphogenesis i.e amniotic band.
Deformation : Are extrinsic disturbances in morphogenesis. Pathologic abnormal compressive forces either acting locally or generalised leading to structural changes in a developing fetus seen clubfeet (Potter sequence component)
Sequence- A cascade of anomalies triggered by one initiating aberation. A single localised aberation in morphogenesis set in motion secondary effect in other organs such as oligohydramnios (Potter). The classic phenotypic feature of oligohydramnios: flatten facies,hypoplastic lungs,dislocated hip,breech,amnion nodosum etc
Malformation syndrome- pathologically related cascade of congenital abnormalies not explained by a single ,localised initiating agent but often caused by a single aetiologic agent such as virus or specific chromosomal abnormality.
6.Agenesis: complete organ absence and its primordium.
7.Aplasia: developmental failure of the primordium , resulting in organ absence
8. Atresia: Is absence of an opening of a hollow visceral organ i.e trachea and intestine.
- Hypoplasia: incomplete development or decreased size of an organ with decreased numbers of cells.
- Hyperplasia: enlargement of an organ due to increased numbers of cells.
11 Dysplasia: Disorganised arrangement of cells
Based on birth weight:
AGA- Appropriate for gestational age
SGA – Small for gestational age.
LGA – Large for gestational age.
Based on gestational age:
Preterm – born before 37weeks
Post term – after 42 weeks.
What are some causes of death under 1
Congenital malformations, deformations, and chromosomal anomalies
Disorders related to short gestation and low birth weight
Sudden infant death syndrome (SIDS)
Newborn affected by maternal complications of pregnancy
Newborn affected by complications of placenta, cord, and membranes
Respiratory distress of newborn
Accidents (unintentional injuries)
Bacterial sepsis of newborn
Intrauterine hypoxia and birth asphyxia
Diseases of the circulatory system
Stages of infant and childhood development
- Neonatal period : 1st four week of life.
- Infancy : 1st year of life.
- Age 1yr to 4years
- Age 5yrs to 14years.
Worldwide, infant mortality varies, 2.3 death per 1000 in Singapore to 160 in Africa continent
CAUSES OF DEATH 1-4 YEARS
Accidents and adverse effects
Congenital malformations, deformations, and chromosomal abnormalities
Malignant neoplasms
Homicide and legal intervention
Diseases of the heart
Influenza and pneumonia
CONGENITAL ANOMALIES
Definition: A morphologic defect a child is born with.
In USA, 1 in 33 live births has a defect.
Etiology: exact cause remains unknown
The known causes are grouped into 3: genetic, environmental, and multifactorial.
Aetiology
Genetic causes