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Hematology > Diseases and Malignancy > Flashcards

Diseases and Malignancy Flashcards

1
Q

Also known as the Childhood Acute Lymphoblastic Leukemia

FAB Classification

A

L1

Lymphoblastic Leukemia with homogeneity (Small & Homogenous cells)
BEST

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2
Q

Also known as Adult Acute Lymphoblastic Leukemia

FAB Classification

A

L2

Lymphoblastic leukemia w/ HETEROGENEITY (Large & Heterogenous)

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3
Q

Also known as the Burkitt’s type Acute Lymphoblastic Leukemia

FAB Classification

A

L3

Large & Homogenous
POOR PROGNOSIS

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4
Q

B-cell leukemia (B-cell ALL) represents what in the FAB classification

A

L3 (Burkitt’s Leukemia)

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5
Q

This subtype of ALL is positive for CD 10 or common ALL antigen

A

Early pre-B cell
or
Common ALL

Represents FAB L1 (Childhood ALL)

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6
Q

The blasts of the subtype of this form of ALL form spontaneous rosettes w/ sheep red blood cells

A

T-cell Leukemias (T-cell ALL)

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7
Q

Subtype of ALL that is negative for T-cell, B-cell, and CALLA surface antigen

A

Null Cell ALL

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8
Q

Acute Undifferentiated Myeloblastic Leukemia/ Acute Myeloid Leukemia, Minimally differentiated

>30% Myeloblast, Cytochemical profile is usually negative

A

M0

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9
Q

Acute myeloblastic leukemia w/out Maturation/ Acute Myeloblastic Leukemia w/ minimal maturation

>30% myeloblast
<10% granulocytic cells

A

M1

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10
Q

Acute Myeloblastic Leukemia w/ Maturation

>30% Myeloblast
>10% granulocytic cells

A

M2

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11
Q

Acute Promyelocytic Leukemia

> 10% granulocytic cells
30% promyelocytes
w/ Faggot cells

>30% blasts

A

M3

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12
Q

Acute Myelomonocytic Leukemia
aka Naegeli’s

>30% Myeloblast
>20% Granulocytes
20 - <80% promonocytes and monocytes

A

M4

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13
Q

Acute Myelomonocytic Leukemia w/ Eosinophilia

Asssociated w/ 16q Karyotype

A

M4 e

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14
Q

Acute Monoblastic Leukemia Poorly Differentiated/
Schilling’s

>80% monocytic cells
>80% monoblasts

A

M5 a

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15
Q

Acute Monocytic Leukemia Well Differentiated

>80% monocytic Cells
<80% monoblasts

A

M5 b

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16
Q

Erythroleukemia/Di Guglielmo’s Syndrome/
Erythemic Myelosis

>30% myeoblasts
>50% erythroid precursors

A

M6

17
Q

Acute Megakaryocytic Leukemia
(AMegL)

>30% megakaryoblasts

A

M7

18
Q

Most common chronic leukemia in adults

Cytogenic abnormalities: 12 & 14
Increased Smudge cells

A

Chronic Lymphocytic Leukemia

19
Q

Hairy cells
Tartrate-Resistant Acid Phosphatase (TRAP) Positive

A

Hary Cell Leukemia or Leukemic Reticuloendothelesis

20
Q

Cells reacting to neoplasms predominate more than the neoplastic cells themselves

Reed-Sternberg cells

A

Hodgkin’s Lymphoma

21
Q

Proliferation of malignant lymphocytes that are arrested at certain stages of maturation

B-cells

A

Non-Hodgkin’s Lymphoma

22
Q

Cutaaneous lymphoma causing itching, leading to ulecerative tumors

A

Mycosis Fungoides

23
Q

Sezary syndrome

A

Variant of mycosis fungoides presenting as disseminated disease with widespread skin involvement and circulating lymphoma cells

24
Q

-Malignant plasma cells in marrow
-Rare abnormal plasma cell on peripheral smear

A

Multiple Myeloma

25
Q

Abnormal plasma cells in the peripheral blood (>20% circulating plasma or plasma cell counts >2.0 x10^9/L)

A

Plasma Cell Leukemia

Rare disorder generally found only as an acute terminal stage in multipl

26
Q

Monoclonal gammopathy due to increased IgM

A

Waldenstrom’s macroglobulinemia

27
Q

-Philadelphia chromosome
-q arm of chromosome 22 is found to be translocated q arm of chromosome 9
-WBC count is usually 50,000 - 300,000/uL

A

Chronic Myelogenous Leukemia (CML, CGL)

28
Q

-Benign Leukocyte proliferation with WBC count >50,000/uL resulting from certain types of infection or tumors
-Increased LAP score

A

Leukemoid Reaction

29
Q

-Granulocytic & Megakaryocytic proliferation in liver and spleen
-(+) Teardrop-shaped RBC’s

A

Agnogenic Myeloid Metaplasia

Old name: Myelofibrosis with Myeloid metaplasia (MMM)

30
Q

-Absolute polycythemia
-Marked increase incidence of peptic ulcer among patients with PV
-Treatment include phlebotomies at regular interval to reduce hyperviscocity and total red cell mass

A

Polycythemia Vera

Hematology (3 decks)

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