Diseases

Question 1

Describe Amyotrophic Lateral Sclerosis and corresponding lesion

Answer 1

Combination of UMN and LMN signs
Muscle weakness, atrophy, fibrillations, fasciculations combined with hyperreflexia

Lesion…both of the anterior horns of the grey matter (LMN lesion) and corticospinal tract (UMN lesion)

Question 2

Describe Tertiary Syphilis and corresponding lesion

Answer 2

Proprioceptive loss and pain, particularly lower extremities

Lesion…posterior columns of while matter…may extend to posterior roots and root ganglia

Question 3

Describe Pernicious Anemia and corresponding lesion

Answer 3

Proprioceptive loss and UMN weakness

Lesion…posterior columns and corticospinal tracts

Question 4

Describe Polio and corresponding lesion

Answer 4

LMN involved, weakness, atrophy, fasciculations, fibrillations, and hyporeflexia

Lesion…Anterior horn cells

Question 5

Describe Guillain-Barre Syndrome

Answer 5

Sensory and LMN loss

Lesion…peripheral nerve involvement