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M2 Musculoskeletal > Disease & Associated antigens/antibodies > Flashcards

Disease & Associated antigens/antibodies Flashcards

Dr. N somehow said in passing that it was a waste of time for CT/MS to make us learn these markers, so I think it's a good idea to review them a few times.

1
Q

Churg-Strauss OR Microscopic Polyarteritis

A

pANCA

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1
Q

Major Sx for Henoch-Schloen?

A

Henoch

  • J - Joints
  • A - Abdominal pain
  • R - Renal
  • S - Skin
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2
Q

RA (2)

A

HLA-DR4

ACPA

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3
Q

Polymyositis (2)

A

anti-Jo1 (anti-tRNA synthetase)

Anti-SRP

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3
Q

Evaulate this ANA (4)

A

Speckled

  1. CREST/Scleroderma (anti-centromere)
  2. Neonatal Lupus (due to Subacute Lupus) (Anti-Ro/SSA)
  3. SLE (Anti-Smith)
  4. Sjogren’s (Anti-Ro/SSA, Anti-La/SSB)

*remember that this is the most common pattern, but is also the least specific* BUT NOTE THEY ALL START WITH S = S FOR SPECKLED

If you get speckeled pattern, test further for

  • Anti-smith (SLE)
  • Anti-Topo I (Scleroderma-diffuse)
  • Anti-La (Sjogrens, SLE)

also - ​connective tissue disease” (MCTD) - “overlap” condition that is a mix among SLE, scleroderma, and polymyositis features, but without serious renal or pulmonary disease. We were never taught this so w/e.

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4
Q

SLE ANA

A

peripheral pattern

Anti-smith

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4
Q

3 Diagnostic Tests for Fibromyalgia

A

CBC

ESR

TSH

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5
Q

Henoch Schoenlen Purpura

A

IgA

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5
Q

SLE markers(2)

ANA pattern?

A

Anti-dsDNA - highly associated with GN in SLE

Anti-Smith - VERY SPECIFIC for SLE

peripheral “rim” pattern

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7
Q

Marker for:

JIA - Pauci-articular early onset

JIA - Pauci-articular later onset

What does it each indicate?

A

early onset: ANA (+) - chronic uveitis

later onset: HLA-B27 (+) - acute uveitis, lower limb enthesis and/or sacroiliitis

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8
Q

ANA (+), (3)

A

Myopathies (Dermatomyositis, Polymyositis)

Juvenile Idiopathic Arthritis, pauci, early onset; indicates increased likelihood of anterior uveitis

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9
Q

Raynaud’s Phenomenon - typically associated with what?

A

High ANA titer (>160), specifically anti-centromere due to CREST (Scleroderma)

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11
Q

ANA for CREST

A

anti-centromere

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12
Q

Lupus Nephritis

A

Anti-DNA

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12
Q

Ca pyrophosphate dihydrate crystals (CPPD)

Type of Crystals and association

A

blue when parallel to the light

yellow when perpendicular to light

(+) birefringence

rhomboid shape

CHONDROCALCINOSIS

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13
Q

Evaulate this ANA.

A

Rim “Peripheral”

SLE

14
Q

urate crystals

A

yeLLow when paraLLel to the light

bLue when perpendicular to the light

(-) birefringence

pencil shape

15
Q

Dermatomyositis (2)

A

anti-Jo1

anti-Mi2

16
Q

Marker for:

JIA - systemic

A

elevated ESR, CRP

RF (-)

17
Q

Wegener’s “Granulomatosis w. Polyangiitis” GPA

A

cANCA

19
Q

Marker for:

JIA - OLIGO-articular early onset

JIA - OLIGO-articular later onset

What does it each indicate?

A

early: no specific marker, but tenosynovitis
late: RF(+), early erosions, joint destructions, poor functional outcomes; treat with DMARDs early

21
Q

ANA for drug-induced lupus

A

Anti-histone

22
Q

Osteogenica Imperfecta

A

COLIA1, COLIA2 (Type I collagen)

23
Q

Scleroderma - limited form (2)

A

Anti-topoisomerase II

Anti-centromere (CREST)

24
Q

Present in both Polymyositis and Dermatomyositis

A

anti-Jo1

25
Q

Sjogren’s Syndrome (2)

A

Anti-Ro/SSA

Anti-La/SSB

26
Q

elevated CPK (4)

A

Rhabdomyolysis

Drug-induced myopathy (statins only; steroids causes normal CPK)

Polymyositis

Dermatomyositis

27
Q

Major Sx for kawasaki

A
  • kawasaki dz:
  • children = coronary artery aneurysm
  • really = rash (desquamting)
  • like = lymphadenopathy of cervical nodes
  • eating = eye (conjunctivitis)
  • fresh = fever
  • strawberries = tongue
28
Q

HLA-B27 (3)

A
  1. SpA
  2. Reactive Arthritis
  3. Juvenile Idiopathic Arthritis - pauci form, late onset (50% of these patients develop SpA
29
Q

RF (5)

A
  1. RA
  2. elderly
  3. bacterial endocarditis
  4. HepC patients
  5. Juvenile Idiopathic Arthritis - polyarticular, late onset
31
Q

Neonatal Lupus

ANA pattern?

A

Anti-Ro/SSA

speckled

32
Q

Scleroderma - diffuse form

A

Anti-topoisomerase I

33
Q

Ankylosing Spondylitis (SpA) OR Reactive Arthritis

A

HLA-B27

34
Q

Major sx for neonatal lupus

A
  • lupus
  • likes = leukopenia
  • to = thrombocytopenai
  • ruin = rash
  • hearts = heart block

M2 Musculoskeletal (27 decks)

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