Disease & Associated antigens/antibodies Flashcards
Dr. N somehow said in passing that it was a waste of time for CT/MS to make us learn these markers, so I think it's a good idea to review them a few times.
Churg-Strauss OR Microscopic Polyarteritis
pANCA
Major Sx for Henoch-Schloen?
Henoch
- J - Joints
- A - Abdominal pain
- R - Renal
- S - Skin
RA (2)
HLA-DR4
ACPA
Polymyositis (2)
anti-Jo1 (anti-tRNA synthetase)
Anti-SRP
Evaulate this ANA (4)
Speckled
- CREST/Scleroderma (anti-centromere)
- Neonatal Lupus (due to Subacute Lupus) (Anti-Ro/SSA)
- SLE (Anti-Smith)
- Sjogren’s (Anti-Ro/SSA, Anti-La/SSB)
*remember that this is the most common pattern, but is also the least specific* BUT NOTE THEY ALL START WITH S = S FOR SPECKLED
If you get speckeled pattern, test further for
- Anti-smith (SLE)
- Anti-Topo I (Scleroderma-diffuse)
- Anti-La (Sjogrens, SLE)
also - connective tissue disease” (MCTD) - “overlap” condition that is a mix among SLE, scleroderma, and polymyositis features, but without serious renal or pulmonary disease. We were never taught this so w/e.
SLE ANA
peripheral pattern
Anti-smith
3 Diagnostic Tests for Fibromyalgia
CBC
ESR
TSH
Henoch Schoenlen Purpura
IgA
SLE markers(2)
ANA pattern?
Anti-dsDNA - highly associated with GN in SLE
Anti-Smith - VERY SPECIFIC for SLE
peripheral “rim” pattern
Marker for:
JIA - Pauci-articular early onset
JIA - Pauci-articular later onset
What does it each indicate?
early onset: ANA (+) - chronic uveitis
later onset: HLA-B27 (+) - acute uveitis, lower limb enthesis and/or sacroiliitis
ANA (+), (3)
Myopathies (Dermatomyositis, Polymyositis)
Juvenile Idiopathic Arthritis, pauci, early onset; indicates increased likelihood of anterior uveitis
Raynaud’s Phenomenon - typically associated with what?
High ANA titer (>160), specifically anti-centromere due to CREST (Scleroderma)
ANA for CREST
anti-centromere
Lupus Nephritis
Anti-DNA
Ca pyrophosphate dihydrate crystals (CPPD)
Type of Crystals and association
blue when parallel to the light
yellow when perpendicular to light
(+) birefringence
rhomboid shape
CHONDROCALCINOSIS
Evaulate this ANA.
Rim “Peripheral”
SLE
urate crystals
yeLLow when paraLLel to the light
bLue when perpendicular to the light
(-) birefringence
pencil shape
Dermatomyositis (2)
anti-Jo1
anti-Mi2
Marker for:
JIA - systemic
elevated ESR, CRP
RF (-)
Wegener’s “Granulomatosis w. Polyangiitis” GPA
cANCA
Marker for:
JIA - OLIGO-articular early onset
JIA - OLIGO-articular later onset
What does it each indicate?
early: no specific marker, but tenosynovitis
late: RF(+), early erosions, joint destructions, poor functional outcomes; treat with DMARDs early
ANA for drug-induced lupus
Anti-histone
Osteogenica Imperfecta
COLIA1, COLIA2 (Type I collagen)
Scleroderma - limited form (2)
Anti-topoisomerase II
Anti-centromere (CREST)
