Direct Oral Anticoagulant (DOAC)

Question 1

Brand name for dabigatran?

Answer 1

Pradaxa

Question 2

Class and MOA

Answer 2

class: direct oral anticoagulant

MOA: competitive reversible direct thrombin inhibitor and prevents the development of the thrombus; both free and clot-bound thrombin and thrombin-induced platelet aggregation are inhibited

Question 3

indications?

Answer 3

treatment and prevention of DVT and PE
prevention of stroke and systemic embolism in nonvalular Afib
prevention of DVT/PE after hip surgery

Question 4

contraindiction?

Answer 4

active bleeding, prosthetic heart valve, hypersensitivity

Question 5

Common ADR?

Answer 5

dyspepsia, gastritis

Question 6

Less common ADR?

Answer 6

Bleeding and GERD

Question 7

Rare but serious ADR?

Answer 7

major bleeding, MI, intracranial hemorrhage

Question 8

Monitoring?

Answer 8

Efficacy: prevention or recurrence of DVT/PE

Toxicity: S/S of bleeding, evaluate renal fxn, not recommended in nonvalvar heart disease