Antiplatelet Agent

Question 1

what is the brand name for prasugrel?

Answer 1

Effient

Question 2

Prasugrel dosage form?

Answer 2

oral tablet

Question 3

Prasugrel indication?

Answer 3

prevention of thromboembolism after percutaneous coronary intervention (in combination with ASA)

Question 4

Prasugrel MOA?

Answer 4

Prasugrel is an inhibitor of platelet activation and aggregation through the irreversible binding of its active metabolite to the P2Y12 class of ADP receptors on platelets.

Question 5

Prasugrel contraindication?

Answer 5

Active bleeding, history of transient ischemic attack or stroke

Question 6

Prasugrel ADR?

Answer 6

Common: None

Less Common: HTN, hyperlipidemia, backache, headache, epistaxis (nosebleed)

Serious: atrial fibrillation, colon cancer, major bleeding, TTP (blood disorder that results in blood clots forming in the small blood vessels throughout the body), angioedema

Question 7

Prasugrel Monitoring:

Answer 7

efficacy: stent patency and prevention if clotting
toxicity: Monitor for signs and symptoms of bleeding. Consider periodic hematocrit/hemoglobin, as well as platelet function testing.

Question 8

Prasugrel key patient counseling point?

Answer 8

may be taken with or without food; tablets can be crushed but should not be split for purpose for dividing doses

**early d/c can lead to increased risk of subsequent CV events, pt weighs under 60 kg, consider 5 mg po qd due to increased risk of bleeding