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Drug cards > Diphenhydramine > Flashcards

Diphenhydramine Flashcards

1
Q

Diphenhydramine trade name

A

Benadryl

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2
Q

Diphenhydramine class

A

Antiemetic, antihistamine

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3
Q

Diphenhydramine MOA

A

Allergic reaction/anphylaxis-H1 R antagonist blocks histamine binding to endothelial cell receptors, decreases vascular permeability and vasodialation
Dystonic reactions- ACh-R antagonist supresses central cholinergic activity and inhibits dopamine reuptake- prolongs action of dopamine and restores cholinergic/ dopaminergic balance in basal ganglia

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4
Q

Diphenhydramine onset/ duration

A

Onset 10-15 (IV) 15-30 (PO) 20-30 (IM)
Duration 6-8 hours

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5
Q

Diphenhydramine indications

A

Allergic reaction
Dystonia/ Akathisia
Behavioral emergencies
Nausea/Vomiting
Pain management
Poisoning/Substance abuse

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6
Q

Diphenhydramine dose

A

Adult 25-50mg IV/IO/IM/PO
Pediatric 1.25mg/kg PO
1mg IV/IO/IM max 50

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7
Q

Diphenhydramine contraindications

A

Hypersensitivity to medication

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8
Q

Diphenhydramine side effects

A

Palpitations
Hypotension
Sedation
Drowsiness
Dizziness
Fatigue
Headache
Blurred vision
Dries bronchial secretions
Euphoria

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