Dimension Of Time Flashcards
Rhythms (maintenance repair other processes)( hours days weeks months)
Homeostasis (maintenance of steady state) (sec min hours)
Energy and info flow ( action potential and enzymatic reactions) ( nanosecond to sec )
Yep
Trajectory
Growth development aging
Months years decades
Lifespan
Average lisp an in canada 80.7 years highly variable
Okay
If we can find things to measure objectively then we can track ageing/disease process
We refer to these as
Bio markers or indicators of the biological state of the organism
Growth tables are important tools in assessing health early in life
Slow growth - infectious disease hormonal probs
Fast growth - over nutrition hormonal probs (excess growth hormone)
As you age osteoporosis occurs
Chronic pain which could lead to wheel chair
Muscle mass is lost
Males -associated with decrease in testosterone and IGF-1 and inactive
Females - associated with inactivity
Prevent resistance training 2-3 times per week for each major muscle group
Diet - protein creatine fish oil
Oral glucose load of 75 grams - trutol
Shows proper levels no matter what
Costly
Glycosylated hemoglobin
Around 5-7% of total Hb
Hard to cheat because Non enzymatic reaction with glucose Lysine and serine residues Non reversible Give longer view (life do rbc)
Problem
Not consistent in labs
Cost
Bio marker
Need to
- reflect normal function or disease processes or predict the risk of future development of disease
- have a predictive range across an identifiable category of individuals or must be routinely monitored over time within each individual
- have methods available for accurate and precise measurement
-many kinds
-most have normal range and diagnostic values
Can change during the life span in relationship to age sex physiological state of patient
New era of bio markers
Can now look at genes proteins metabolites at once
Can look for change in clusters of genes proteins metabolites relative to a norm
