Digoxin Flashcards
mechanism of digoxin
inhibits Na/K ATPase to increase inotropy
stimulates vagus to decrease HR
List 6 side effects of digoxin
nausea vomiting diarrhoea dizziness gynaecomasria arrhythmia
Symptoms of digoxin toxicity? (7)
Yellow halo GI Disturbances Loss of appetite Brady cardia abdominal pain syncope hyperkalaemia
Risk factors for digoxin toxicity (5)
hypokalaemia elderly renal failure hypothyroid certain drugs
hypokalaemia elderly renal failure hypothyroid certain drugs
All risk factors for ..
Digoxin toxicity
What drugs increase the risk of digoxin toxicity? (5)
quinidine amiodarone verapamil diltiazem erythromycin
Why do certain drugs increase the risk of digoxin toxicity?
they affect p-glycoprotein which determines plasma concentration of digoxin
Why does HYPOkalaemia cause problems with digoxin?
Usually potassium is competing for ATPase pump binding site
When to measure digoxin levels?
6hrs after last dose
does concentration of digoxin correlate to toxicity features?
No
Can have toxicity in therapeutic window
Digoxin therapeutic window
The adverse effects of digoxin are frequently due to its narrow therapeutic window
Treating digoxin toxicity
Digibind
Correct electrolyte abnormalities
visual disturbance in which objects appear yellow?
xanthopsia
xanthopsia?
Xanthopsia is a color vision deficiency in which there is a predominance of yellow in vision due to a yellowing of the optical media of the eye. The most common cause is digoxin’s inhibitory action on the sodium pump, and the development of cataracts which can cause a yellow filtering effect.
