Diffusion through placental membrane Flashcards

1
Q

Simple diffusion from sinuses through villus membrane down pressure gradient to fetus
from maternal blood − _____ mm Hg

mean PO2 in villus _____mm Hg

mean PO2 in fetal blood _____mm Hg

A

from maternal blood − 100 mm Hg
mean PO2 in villus − 50 mm Hg
mean PO2 in fetal blood − 30 mm Hg

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2
Q

Fetal Hb (Hb F- 22) has higher affinity for O2: can carry ____more O2 than maternal Hgb

A

20-30%

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3
Q

____shift of Oxy-Hb curve (newborn) ; later shift to ____

A

left, right

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4
Q

Fetal Hb concentration in blood is ____ greater than in mother

A

50%

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5
Q

Anemia when Hb ___g/dl (newborn) and ___ g/dl in older than 3 months

A

<13, < 10

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6
Q

CO2: builds up until it is slightly higher in fetus umbilical arteries_____ than in intervillous space ______

A

(48 mm Hg), (43 mm Hg)

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7
Q

Affinity for CO2 is _____ in fetus, favoring transfer from fetus to mother

A

lower

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8
Q

Receptor mediated endocytosis from mother: ____

A

LDL

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9
Q

Renin increases late in gestation due to

A
  1. Renal sympathetic nerve activity
  2. Reduction in Na and blood volume
  3. Change in renal perfusion pressure
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10
Q

Diagnosis of fetal well-being:

Noninvasive

A

Transvaginal ultrasound: visualize vertebrae, kidneys,

bladder, fingers and toes by 12 wks gestation

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11
Q

Diagnosis of fetal well-being

Invasive

A

Amniocentesis: 14-16 wks; when amniotic cavity contains 150-200 ml (remove 20 ml); with simultaneous ultrasound; karyotyping, biochemical analyses, DNA

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12
Q

cytogenetic and biochemical testing recommended after 10 wks gestation; usually 2nd and 3rd trimester

A

Chorionic villus sampling

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13
Q

transabdominal; from 17 wks into umbilical vein about 1 cm from placental cord insertion site

A

Fetal blood sampling

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