Differential & Work-up: Numbness/Weakness, Insomnia Flashcards
53 yo M presents following a 20·minute episode of right-sided arm and face numbness. His symptoms had totally resolved by the time he got to the emergency department. He has a history of hypertension, migraine, diabetes mellitus, and heavy smoking. Physical examination is within normal limits.
- Transient ischemic attack (TIA)
- Stroke
- Migraine with sensory aura
- Hypoglycemia
- Seizure with Todd paresis
WORK-UP FOR:
- Transient ischemic attack (TIA)
- Stroke
- Migraine with sensory aura
- Hypoglycemia
- Seizure with Todd paresis
- CT-head
- CBC
- Electrolytes, glucose
- Fasting lipid panel
- ECG
- MRI-brain, with DWI
- Doppler U/S-carotid
- Echocardiography
- EEG
68 yo M presents with slurred speech, right facial drooping and numbness, and right-hand weakness. Babinski sign is present on the right, he has weakness of the right side of his body. and his deep tendon reflexes are brisk. He has a history of hypertension, diabetes mellitus, and heavy smoking.
- Stroke
- TIA
- Seizure with Todd paresis
- Intracranial neoplasm
- Subdural or epidural
- hematoma
- Hypoglycemia
WORK UP FOR:
- Stroke
- TIA
- Seizure with Todd paresis
- Intracranial neoplasm
- Subdural or epidural
- hematoma
- Hypoglycemia
- CT-head
- CBC
- Electrolytes, glucose
- PT/PTT/INR
- Fasting lipid panel
- MRI-brain, with DWI
- MRA
- Doppler U/S-carotid
- Echocardiography
- ECG
33 yo F presents with ascending loss of strength and numbness in her lower legs over the past 2 weeks. She had a recent URI. Examination shows weakness of her lower limbs with reduced reflexes.
- Guillain-Barre syndrome
- Multiple sclerosis
- Transverse myelitis
- Spinal cord compression
- Peripheral neuropathy
WORK UP FOR:
- Guillain-Barre syndrome
- Multiple sclerosis
- Transverse myelitis
- Spinal cord compression
- Peripheral neuropathy
- CBC
- Electrolytes
- MRI-spine
- CPK
- Electromyography
- Nerve conduction studies
- LP-CSF analysis
- PFTs
- Serum B12
30 yo F presents with weakness, loss of sensation, and tingling in her left leg that started this morning. She also experienced right eye pain with reduced vision that resolved transiently 3 months ago. She reports feeling “electric shocks” down her spine upon flexing her head. Examination reveals left lower limb weakness and ataxia.
- Multiple sclerosis
- Stroke
- CNS vasculitis
- Conversion disorder
- Malingering
- CNS tumor
- Vitamin B12 deficiency
- Neurosyphilis
WORK UP FOR:
- Multiple sclerosis
- Stroke
- CNS vasculitis
- Conversion disorder
- Malingering
- CNS tumor
- Vitamin B12 deficiency
- Neurosyphilis
- CBC
- ESR
- ANA, ANCA
- VDRL/RPR
- SerumB12
- MRI-brain, spine
- LP-CSF analysis
- Visual evoked potentials
55 yo M presents with tingling and numbness in his hands and feet (glove-and-stocking distribution) for the past 2 months. He has a history of diabetes mellitus, hypertension, and alcoholism. There is decreased soft touch, vibratory, and position sense in the feet, reflexes are absent.
- Diabetic peripheral neuropathy
- Alcoholic peripheral neuropathy
- B12 deficiency
- Uremic nephropathy
- Hypocalcemia
- Hyperventilation
- Paraproteinemia/ myeloma
WORK UP FOR:
- Diabetic peripheral neuropathy
- Alcoholic peripheral neuropathy
- B12 deficiency
- Uremic nephropathy
- Hypocalcemia
- Hyperventilation
- Paraproteinemia/ myeloma
- HbA1C
- Glucose
- ESR
- Calcium
- SerumB12
- UA
- TFTs
- Urea, electrolytes
- Serum and urine protein electrophoresis
- Electromyography
- Nerve conduction studies
40 yo F presents with occasional double vision and droopy eyelids at night with normalization by morning. Her past medical history is significant for hypothyroidism.
- Myasthenia gravis
- Multiple sclerosis
- Intracranial neoplasm compressing CN III, IV, VI
- Horner syndrome
- Botulism
WORK UP FOR:
- Myasthenia gravis
- Multiple sclerosis
- Intracranial neoplasm compressing CN III, IV, VI
- Horner syndrome
- Botulism
- Ice pack test
- Tensilon ( edrophonium) test
- Anti-ACh receptor antibodies
- Electromyography
- Nerve conduction studies
- CXR
- CT-chest
- MRI-brain
25 yo M presents with hemiparesis after a tonic-clonic seizure that resolved within a few hours.
- Todd paralysis
- TIA
- Stroke
- Intracranial neoplasm
- Hemiplegic migraine
- Head injury
- Hypoglycemia
- Malingering
WORK UP FOR:
- Todd paralysis
- TIA
- Stroke
- Intracranial neoplasm
- Hemiplegic migraine
- Head injury
- Hypoglycemia
- Malingering
- CBC
- Glucose, electrolytes
- Toxin levels
- EEG
- CT-brain
- MRI-brain
- Doppler U/S-carotid
56 yo obese F c/o tingling and numbness of her thumb, index finger, and middle finger for the past 5 months. Her symptoms are constant, have progressively worsened, and are relieved with rest. She works as a secretary. She has a history of fatigue and a 20~lb (9~kg) weight gain over the same period.
- Carpal tunnel syndrome secondary to overuse
- Overuse injury of median nerve
- Cervical disc disease
- Medial epicondylitis