Diarrhea

Question 1

What are the drugs that function as intestinal absorbants?

Answer 1

Kaolin, bismuth subcarbonate, pectin, diosmectite

Question 2

What is the MOA of intestinal absorbants?

Answer 2

Absorb intestinal toxins. They prevent toxin interaction with GIT

Question 3

What class of drugs do these drugs belong to? Diphenoxylate, loperamide, codeine

Answer 3

Antipropulsives

Question 4

What drug is Diphenoxylate usually administered with?

Answer 4

Atropine

Question 5

What is the onset and DOA of DIphenoxylate?

Answer 5

Onset:45-60 min
DOA: 3-4hrs

Question 6

What are the AE of antipropulsives?

Answer 6

constipation, abd cramps, drowsiness, dry mouth

Question 7

T or F: Diphenoxylate crosses the BBB which has the potential for abuse and is excreted in milk

Answer 7

True

Question 8

What are the CI for Diphenoxylate?

Answer 8

children <4 yrs, Down’s syndrome

Question 9

T or F: Loperimide has 100% oral absorption?

Answer 9

False. Poor oral absorption at 40%

Question 10

What are the CI of Loperimide?

Answer 10

Diarrhea of infective origin, pseudomembranous colitis, children <6 yrs, IBS