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Pharmacology > Antidepressants > Flashcards

Antidepressants Flashcards

1
Q

What class of drug is Fluxetine?

A

SSRI

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2
Q

What class of drug is Paroxetine?

A

SSRI

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3
Q

What class of drug is Atomoxentine?

A

SSRI

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4
Q

What class of drug is Citalopram?

A

SSRI

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5
Q

What class of drug is Escitalopram?

A

SSRI

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6
Q

What is the mechanism of action of SSRIs?

A

inhibit reuptake of serotonin

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7
Q

Adverse effects of Fluxetine include cardiovascular and suicide risk in the elderly as well as anorexia in the first few months of use

A

true

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8
Q

SSRIs A/E:

A

N & V, D, anxiety, restlessness, insomnia, sexual dysfunction

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9
Q

What class of drug is Venlafaxine?

A

SNRIs

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10
Q

What class of drug is Desvanlafaxine?

A

SNRIs

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11
Q

What class of drug is Duloxetine?

A

SNRIs

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12
Q

SNRIs mechanism of action?

A

prevent reuptake of serotonin, NE and DA

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13
Q

A/E of SSRIs

A

N, D, anxiety, restlessness, insomnia, sexual dysfunction, increased BP & HR, orthostatic hypotension

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14
Q

What class of drug is Imipramine?

A

TCA

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15
Q

What class of drug is Clomipramine?

A

TCA

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16
Q

What class of drug is Amitriptyline?

A

TCA

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17
Q

What class of drug is Amoxapine?

18
Q

What class of drug is Doxepin?

19
Q

What class of drug is trimipramine?

20
Q

What class of drug is Mirtazapine?

21
Q

What class of drug is Mianterin?

22
Q

What is the mechanism of action of TCAs?

A

Prevent the reuptake of serotonin and NE

23
Q

A/E of TCAs

A

N, D, anxiety, restlessness, insomnia, sexual dysfunction, increased BP & HR, orthostatic hypotension

24
Q

What class of drug is Tranylcypromine?

25
Q

What class of drug is Moclobemide?

26
Q

What class of drug is phenelzine?

27
Q

What drug class had this MOA? inhibit the oxidative deamination of NA, DA and serotonin

A

Monoamine oxidase Inhibitors (MOI)

28
Q

What drug class has these adverse effects? Sedation, postural hypotension (sympathetic block), insomnia, impotence, anxiety, restlessness, confusion

29
Q

What is the mechanism of action of action of Bupropion?

A

inhibit the reuptake of NE and dopamine

30
Q

What are the A/E of bupropion?

A

N & V, headaches, activation, agitation, hypertension and insomnia (less sexual dysfunction)

31
Q

Which drug do these contraindications belong to? Risk for seizures, seizure disorder, history of anorexia or bulimia, using or withdrawing from alcohol or benzos

32
Q

Mirtazapine has no action at histamine receptors

A

False. Mitrazapine antagonizes adrenergic, 5-HT2, 5-HT3 receptors- increased NE and 5-HT. Also has activity at histamine receptors

33
Q

What drug has these contraindications? Pregnancy, lactation, <18 yrs, MAOIs

A

Mirtazapine

34
Q

A/E of Mirtazapine

A

Sedation, weight gain, constipation, dry mouth, appetite
Decreased risk for sexual dysfunction compared to SSRIs

35
Q

Trazadone MOA?

A

Inhibit serotonin reuptake

36
Q

Contraindications for trazadone?

A

Alcohol or hypnotics intoxication, acute MI, < 18 yrs

37
Q

A/E of trazadone

A

Sedation, N, sexual dysfunction and orthostatic hypotension

38
Q

What drug has a similar MOA to trazadone?

A

Nefazodone

39
Q

What is the first line drug for depression?

A

Nefazodone

40
Q

What are the adverse effects of Nefazodone?

A

Dry mouth, nausea, constipation, visual alterations, orthostatic hypotension, sedation
Hepatic failure- most common

Pharmacology (11 decks)

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