Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

endocrine > diabetic drugs > Flashcards

diabetic drugs Flashcards

1
Q

metformin mechanism of action

A

inhibits complex 1 in the mitochondrial respiratory chain
lowering ATP > rise in AMP
then a reduction in gluconeogenesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

side effects of metaformin

A

diarrhoea and abdominal pain
lactic acidosis
weight neutral

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

is metformin a biguanide

A

yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

most common sulphonylureas

A

gliclazide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

mechanism of action of sulphonylureas

A

glucose stimulated insulin secretion

causes insulin release independent of glucose > hypoglycaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

side effects of sulphonylureas

A

weight gain
hypoglycaemia
increased risk of MI and CVD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

PPARgamma ligands

A

regulator of lipid and glucose metabolism and therefore its synthetic ligands such as glitazones - the derivatives of thiazolidinediones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

mechanism of action of TZD

A

Activate PPAR-gamma receptor in adipocytes to promote adipogenesis and fatty acid uptake

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

side effects of TZD

A

weight gain
fluid retention
fracture risk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

example of TZD

A

pioglitazone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

mechanism of action of GLP-1 agonists

A

incretin mimetic which inhibits glucagon secretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

how is incretins given

A

Subcutaneously

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

DPP-4 inhibitors mechanism of action

A

increases incretin levels which inhibit glucagon secretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

SGLT-2 inhibitors mechanism of action

A

inhibits reabsorption of glucose in the kidneys

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what type of drug is sitagliptin

A

DDP-4 inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly

endocrine (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions