Diabetes PHARM Flashcards
Metformin
Indications
Type 2 DM (non-insulin dependent) A1C > 6.5%
Safe in pregnancy and childhood (A1C > 9%)
PCOS to increase fertility
(insulin insensitivity, increases insulin = increase androgens = decrease fertility)
Metformin
MOA
- GI: Decrease GI absorption of glucose
- Muscle/Fat: Increase insulin sensitivity in periphery
- Liver: Prevents liver from synthesizing glucose (gluconeogenesis, glycogenolysis)
Metformin
SE/AE
- GI: N/V/D/anorexia
- start low, go slow - Macrocytic anemia (absorption vitamin B12 and folic acid inhibited)
- pre-disposed to anemia - Lactic acidosis
- prevent mitochondria from oxidizing lactic acid
Metformin
Pros/Cons
Pros
- Cardioprotective: decrease MI
- Weight neutral
- Low risk hypoglycemia
Cons
- Toxicity (not metabolized, excreted by kidney)
- liver disease
- lactic acidosis
Metformin
Contraindications
- Kidney disease and nephrotoxic medications
- high risk toxicity
- D/C contrast dyes - Liver disease
- high risk toxicity and lactic acidosis - Risk or history of lactic acidosis
- Liver disease
- alcoholism
- hypoxia
- sepsis
PRN medications
Metformin
- Vitamin B12
- Folic Acid
- drink water to flush out
Patient Education
Metformin
- Take PRNs
- vitamin B12
- Folic acid
- monitor S&S anemia - Inform MD before contrast dyes
- Monitor for S&S lactic acidosis
- hyperventilation
- malaise
Metformin
Drug class
Biguanide
Sulfonylureas
Examples
Glyburide
Glimepiride
Glipizide
Insulin secretagogue
Sulfonylureas
Indication
Type 2 DM
non-insulin dependent
*Insulin secretagogues
Sulfonylureas
MOA
- increase insulin secretion
- Blocks K ATPase islet cell
- Depolarization
- influx of calcium
- release of insulin
*Insulin secretagogue
Sulfonylureas
SE/AE
- Hypoglycemia
- increases release of insulin regardless of BG
- *Glyburide > - Hypoglycemic shock
- Weight gain
Sulfonylureas
Con
Weight gain
- increases insulin release
- anabolic hormone
Hypoglycemia
* do not combine with meglitinides or insulin
Cardio- neutral
Sulfonylureas
Contraindications
Liver or kidney disease
- accumulation drug to toxic levels
Hypoglycemia
Pregnancy and breast feeding
Insulin
Rx. Meglitinides (same mechanism, hypoglycemia)
Meglitinide
Examples
RepaGLINIDE
NateGLINIDE
Insulin secretagogues
Meglitinide
Indication
Lower post-prandial glucose
Taken TID with meals
Type 2 DM (non insulin dependent)
*insulin secretagogue
Meglitinide
MOA
*Same as sulfonylureases (faster acting, must be taken with meals)
- Increase insulin secretion
- Block K ATPase
- depolarization
- influx calcium
- release insulin
Meglitinide
SE/AE
Hypoglycemia and hypoglycemic shock
- must be dosed with meals
Meglitinide
Pros/Cons
Cons
- weight gain
- hypoglycemia
- cardio neutral