Diabetes Mellitus Management Flashcards
Hyperglycemia
Elevated blood glucose levels
What are the characteristics of hyperglycemia?
Polyuria, polyphagia, nausea, fatigue, and blurred vision.
Hypoglycemia
Low blood glucose.
What are the characteristics of hypoglycemia?
Characterized by pallor, tremor, diaphoresis (sweating), palpations, hunger, visual disturbances, weakness, paresthesias, confusion, agitation, coma, and death.
Diabetic ketoacidosis (DKA) is
A complication most common if pt that have type 1 diabetes, is categorized by hyperglycemia, ketones in the urine, increased respiratory rate and fruity breath odor.
Ketoacidosis
Abnormally high concentration of ketones in the blood and urine. Typically, greater than 300mg/dl. A medical emergency.
Hyperglycemic-hyperosmolar state (HHS)
A coma. A medical emergency, more common in pt that have type 2 diabetes. Characterized by severe hyperglycemia, only slight or no ketosis and profound dehydration.
Polyphagia
Excessive hunger
Polydipsia
excessive thirst
Polyuria
Excessive urine output
What are the chronic complications of diabetes?
Macrovascular complications- including coronary artery disease, cerebrovascular accident, and peripheral vascular disease. Microvascular complications- including retinopathy, neuropathy, and nephropathy.
Infections- of the skin, urinary tract, and vagina.
Neuropathy
Any kidney disease
Sulfonylureas
(Oral) Class of antihyperglycemic agents that stimulate the release of insulin from pancreatic islets.
Thiazolidinediones
(Oral) Increases the cellular response to insulin by decreasing insulin resistance.
Meglitinides (glinides)
(Oral) Works by increasing insulin secretion by the beta cells of the pancreas
Biguanides
(Oral) Works by reducing haptic glucose production while increasing insulin action on muscle glucose intake.
Examples include Metformin
Alpha-glucosidase inhibitors
(Oral) Works by delaying carbohydrate digestion.
Dipeptidyl peptidase-4 (DPP-4) inhibitors
(Oral) Works by augmenting naturally occurring incretin hormones
Rapid-acting insulin
Examples: Lispro (Humalog), Aspart (Novolog), Glulisine (Apidra)
Onset: 15-30 minutes
Peak: 30-150 minutes
Duration: 3-6 hours
Use: Taken just before or after meals to control blood sugar spikes.
Short-acting insulin
Examples: Regular (Humulin R, Novolin R)
Onset: 30 minutes to 1 hour
Peak: 1-5 hours
Duration: 5-10 hours
Use: Taken 30 minutes before meals.
Intermediate-acting insulin
Examples: NPH (Humulin N, Novolin N)
Onset: 1-2 hours
Peak: 6-14 hours
Duration: 16-24 hours
Use: Often used once or twice a day to provide basal insulin coverage.
Long-actin insulin
Examples: Glargine (Lantus, Basaglar), Detemir (Levemir), Degludec (Tresiba)
Onset: 1-2 hours
Peak: 12-24
Duration: Up to 24 hours or more
Use: Provides steady insulin levels throughout the day and night.
What is type 1 diabetes mellitus?
Previously called insulin dependednt. It involves the complete destruction of the beta cells. Beta cells produce insulin.
What is type 2 diabetes mellitus?
Insulin resistance and impaired insulin secretion. The pancreas is producing insulin but not enough to sustain the body.