Diabetes Mellitus Flashcards
Other names for Type 2 DM: (7)
Non-Insulin Dependent
Adult Type
Mature Onset
Stable Diabetes
Ketosis-Resistant
Receptor-Deficient DM
Geneticist’s Nightmare
Why is Type 2 DM is regarded as the Geneticist’s Nightmare?
because the classical pattern of genetic transmission does not apply to Type 2 DM
Other names for Type of 1 DM: (4)
Insulin Dependent DM
Juvenile Onset DM
Brittle Diabetes
Ketosis-Prone Diabetes
Pathogenesis of Type 1 DM:
Occurs only if 80-90% of beta-cell is destroyed
Pathogenesis of Type 2 DM:
Insulin Resistance (due to alteration/ absence
of insulin receptors)
Match:
Type 1 DM
Type 2 DM
a. Children/Teens
b. Adults
Type 1 DM - Children/Teens
Type 2 DM - Adults
Risk factors:
Type 1 DM
Type 2 DM
Type 1 - Autoimmunity
Type 2: Genetics, Race, Obesity, Sedentary Lifestyle, Ethnicity, Polycystic Ovarian Syndrome, Hypertension
Ketosis:
Controlled poorly; common
Type 1 DM
Ketosis:
RARE
Type 2 DM
Medication:
Type 1 DM
Insulin
Medication:
Type 2 DM
Oral agents
Symptoms:
Abrupt
Type 1 DM
Symptoms:
Gradual
Type 2 DM
Cause of DM is UNKNOWN
Idiopathic Type 1 DM
Diabetes mellitus that does not have β-cell autoantibodies and have episodic requirements for insulin replacement
Idiopathic Type 1 DM