Diabetes (II) Flashcards
Do not use if CrCl <30
metformin
SGLT-2
exenatide
glyburide
do not use if HF
TZD
alogliptin
saxagliptin
Do not use if peripheral neuropathy, PAD, ulcer
canagliflozin
Do not use if GI disorders
GLP-1
pranlintide
sulfa allergy, GPPD deficiency
SU
risk of lactic acidosis
metformin
risk of hepatotoxicity
tzd, alogliptin
risk of hypotension/dehydration/UTI/gentital infections
SGLT-2
risk of hyperkalemia
canagliflozin
risk of hypokalemia
insulin
risk of pancreatitis
DDP-4
GLP-1
risk of hypersensitivity reaction
SU
DPP-4
insulin
risk of ketoacidosis
SGLT-2
risk of bladder cancer
pioglitazone
dapagliflozin
risk of thyroid cancer
GLP-1
results in biggest decrease in A1c
insulin
metformin, SU
TZD
results in the greatest weight loss
SGLT2
GLP-1
pramlintide
results in hypoglycemia
insulin
SU
meglitinides
pramlintide
results in weight gain
insulin
SU
TZD
meglitinides
CVD benefit in patients with T2DM
empagliflozin
liraglutide
canagliflozin
cheapest drug options
metformin
SU
TZD
injectable formulations
insulin
GLP-1
pramlintide
SS scale adjustments
2 U every 50 starting from 150
inpatient glucose
140-180
hypoglycemic
<70
room temperature stability 3 days
opened alfreeza
room temperature stability 10 days
unopened alfreeza
humalog mix,humilin mix, pen
room temperature stability 14 days
humulin n, novolog mix pens, trulicity/adlyxin pens
room temperature stability 21 days
xultophy
room temperature stability 28 days
rapid acting, mix vials, r pen, lantus, basaglar, bydureon, soliqua
room temp stability 30 days
byetta, victoza
room temp stability 31 days
humulin r vials
room temp stability 40 days
humulin r u 500
room temp stability 42 days
novolin r, toujeo, levemir
room temperature stability 56 days
tresiba, ozempic
basal insulin dosing
0.1-0/2 U/kg/day or 10U/day
rapid correction factor
1800/TDD
regular correction factor
1500/TDD
correction dose
BG now- bg target/correction factor
TDD=
0.6 U/kg/day *based on TBW
insulin carb ratio for rapid
500/TDD
insulin carb ratio for regular
450/TDD
insulin pens that do not contain 100U/ml
humalog kwikpen:200
humulin R U 500
tresiba 200
toujeo 300
insulin pens that do not contain 3 ml
toujeo 1.5ML
alpha glucosidase inhibitor
acarbose (precose)
migilitol (glyset)
SU
glipizide (glucotrol)
glimepride (amaryl)
glyburide (glynase)
melitinides
repaglinide (prandin)
nateglinide (starlix)
TZDs
pioglitazone (actos)
rosiglitazone (avandia)
SGLT-2
canagliflozin (invokana)
empagliflozin (jardiance)
DPP-4
sitagliptin (januvia)
linagliptin (Trajenta)
Bile Acid Binding Resins
chlesevelam (whelcol)
dopamaine agonist
bromocriptine (cycloset)
GLP-1
exenatide (byetta)
exenatide er (bydureon)
liraglutide (victoza, saxenda)
dulaglutide (trulicity)
amylin analog
pramlintide (sylmlinPen)
rapid acting insulin
aspart (novolog)
lispro ( humalog, admelog)
afrezza
short acting insulin
regular insulin (humulin R, novolin R) concentrated regular ( Humulin R U 500)
intermediate acting insulin
NPH insulin ( Humulin N)
long acting
determir (levemir)
glargine (lantus, toujeo,basaglar)
degludec (tresiba)