Diabetes (II) Flashcards
Do not use if CrCl <30
metformin
SGLT-2
exenatide
glyburide
do not use if HF
TZD
alogliptin
saxagliptin
Do not use if peripheral neuropathy, PAD, ulcer
canagliflozin
Do not use if GI disorders
GLP-1
pranlintide
sulfa allergy, GPPD deficiency
SU
risk of lactic acidosis
metformin
risk of hepatotoxicity
tzd, alogliptin
risk of hypotension/dehydration/UTI/gentital infections
SGLT-2
risk of hyperkalemia
canagliflozin
risk of hypokalemia
insulin
risk of pancreatitis
DDP-4
GLP-1
risk of hypersensitivity reaction
SU
DPP-4
insulin
risk of ketoacidosis
SGLT-2
risk of bladder cancer
pioglitazone
dapagliflozin
risk of thyroid cancer
GLP-1
results in biggest decrease in A1c
insulin
metformin, SU
TZD
results in the greatest weight loss
SGLT2
GLP-1
pramlintide
results in hypoglycemia
insulin
SU
meglitinides
pramlintide
results in weight gain
insulin
SU
TZD
meglitinides
CVD benefit in patients with T2DM
empagliflozin
liraglutide
canagliflozin
cheapest drug options
metformin
SU
TZD
injectable formulations
insulin
GLP-1
pramlintide
SS scale adjustments
2 U every 50 starting from 150