Diabetes exam Flashcards
Exocrine Vs Endocrine
Exocrine = pancreatic juices
Endocrine = protein-derived pancreatic hormones ( insulin B cells) and glucagon (A cells)
What are the cells called that produce insulin and glucagon?
Islets of Langerhans
What metabolic processes does the release of glycogen stimulate?
Glycogenolysis
Gluconeogenesis
Lipolysis
What part of the triglyceride can be used in gluconeogenesis
the glycerol backbone
Explain T1DM
An autoimmune disorder where white blood cells attack beta cells of the pancreas resulting in little to no insulin production
What is the term for high glucose in urine?
Glucosuria
Prevalence of T1DM
5% of DM cases
genetic issues (genes) have been linked to the disorder
Clinical symptoms/manifestations of T1DM
- Glucosuria
- Hyperglycemia
- Unexplained weight loss
- Polyphagia (excessive hunger)
- Polydipsia (excessive thirst)
- Polyuria ( excessive urination)
- diabetic ketoacidosis
- fatigue
What is the main diagnostic criteria for T1DM
Diabetic ketoacidosis
When the body goes into lipolysis and ketones are formed as a by product.
- Acidic blood
- Fruity metallic (nail-polish remover) smelling breath
- deep shallow breathes
What is the breath smell called from diabetic ketoacidosis
kassmaul respirations
Prevalence of T2DM
90-95% of all cases
Why does nausea, abdominal pain, and vomiting occur during DKA
Inflammatory cytokines are released as a result of lipolysis which upsets the GI tract
This causes extra dehydration
What is the the name for dehydration caused by hyperglycemia?
Osmotic diuresis
Risk factors for T2DM
- Family history
- high birth weight 8.8 lbs!
- obesity
- altered glucose metabolism
- physical inactivity
- Gestational DM
- older adults and people of color
T2DM Etiology
Insulin resistance and insulin deficiency (the pancreas makes insulin but cells cant use it and then at some point the pancreas gives up…results in deficiency)
Clinical manifestations or T2DM
- Hyperglycemia
- Polyuria
- Blurred vision
- Shaky/sweaty
- Tingling extremities
What are the different testing ways to diagnose DM
Glycated Hemoglobin assays - Hemoglobin A1C (measure glucose bound to hemoglobin protein in RBC)
OGTT - used mainly with GDM
Islet cell autoantibodies - damaged Beta cells
List the mg/dL ranges for normal, pre-diabetes, and diabetes
hA1c % = normal: <5.7% ; pre: 5.7-6.4%; diabetes: >/= 6.5%
FPG (Fasting plasma glucose) = normal: <100 mg/dL; pre: 100-125 mg/dL; diabetes: >/= 126 mg/dL
RPG (random plasma glucose) = diabetes: >/= 200 mg/dL
OGTT = diabetes: >/= 200 mg/dL
Goal ranges for T2DM
hA1c = < 7%
Preprandial = 80-130 mg/dL
Postprandial = <180 mg/dL
Describe recombinant human insulin as a treatment form
Exogeneous insulin that starts at a baseline dosage and is dependent on the person.
Dosages are changed until the right amount is found for that person to properly control blood sugar levels.
Types of recombinant insulin therapy? (delivery methods)
Insulin pumps, insulin pens, insulin syringes, and continuous glucose monitors
Describe insulin therapy requirements and when they might be increased
0.4-1.0
Based on weight mostly
increase if pregnant, illness, and puberty
starting at 0.5
half is prandial (pre/post meal time) and the other half is basal ( long-acting…24 hours)
What are the two different types of insulin and give the onset and duration of both
rapid-acting insulin (mostly administered via an insulin pump and given in bolus at meal-time) onset is 5-20 minutes and duration is 3-5 hours
Long-acting insulin (basal) has an onset of about an hour and duration of 24 hours.
What is the cutoff “safe” blood glucose RPG level for post-prandial?
Anything 180 mg/dL or above for prolonged periods of time is what can be detrimental and cause long-term complications (blindness, neurological damage, kidney damage, narrowing of blood vessels, heart complications…)