Diabetes exam Flashcards

1
Q

Exocrine Vs Endocrine

A

Exocrine = pancreatic juices
Endocrine = protein-derived pancreatic hormones ( insulin B cells) and glucagon (A cells)

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2
Q

What are the cells called that produce insulin and glucagon?

A

Islets of Langerhans

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3
Q

What metabolic processes does the release of glycogen stimulate?

A

Glycogenolysis
Gluconeogenesis
Lipolysis

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4
Q

What part of the triglyceride can be used in gluconeogenesis

A

the glycerol backbone

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5
Q

Explain T1DM

A

An autoimmune disorder where white blood cells attack beta cells of the pancreas resulting in little to no insulin production

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6
Q

What is the term for high glucose in urine?

A

Glucosuria

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7
Q

Prevalence of T1DM

A

5% of DM cases
genetic issues (genes) have been linked to the disorder

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8
Q

Clinical symptoms/manifestations of T1DM

A
  • Glucosuria
  • Hyperglycemia
  • Unexplained weight loss
  • Polyphagia (excessive hunger)
  • Polydipsia (excessive thirst)
  • Polyuria ( excessive urination)
  • diabetic ketoacidosis
  • fatigue
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9
Q

What is the main diagnostic criteria for T1DM

A

Diabetic ketoacidosis
When the body goes into lipolysis and ketones are formed as a by product.
- Acidic blood
- Fruity metallic (nail-polish remover) smelling breath
- deep shallow breathes

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10
Q

What is the breath smell called from diabetic ketoacidosis

A

kassmaul respirations

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11
Q

Prevalence of T2DM

A

90-95% of all cases

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12
Q

Why does nausea, abdominal pain, and vomiting occur during DKA

A

Inflammatory cytokines are released as a result of lipolysis which upsets the GI tract

This causes extra dehydration

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13
Q

What is the the name for dehydration caused by hyperglycemia?

A

Osmotic diuresis

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14
Q

Risk factors for T2DM

A
  • Family history
  • high birth weight 8.8 lbs!
  • obesity
  • altered glucose metabolism
  • physical inactivity
  • Gestational DM
  • older adults and people of color
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15
Q

T2DM Etiology

A

Insulin resistance and insulin deficiency (the pancreas makes insulin but cells cant use it and then at some point the pancreas gives up…results in deficiency)

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16
Q

Clinical manifestations or T2DM

A
  • Hyperglycemia
  • Polyuria
  • Blurred vision
  • Shaky/sweaty
  • Tingling extremities
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17
Q

What are the different testing ways to diagnose DM

A

Glycated Hemoglobin assays - Hemoglobin A1C (measure glucose bound to hemoglobin protein in RBC)

OGTT - used mainly with GDM

Islet cell autoantibodies - damaged Beta cells

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18
Q

List the mg/dL ranges for normal, pre-diabetes, and diabetes

A

hA1c % = normal: <5.7% ; pre: 5.7-6.4%; diabetes: >/= 6.5%

FPG (Fasting plasma glucose) = normal: <100 mg/dL; pre: 100-125 mg/dL; diabetes: >/= 126 mg/dL

RPG (random plasma glucose) = diabetes: >/= 200 mg/dL

OGTT = diabetes: >/= 200 mg/dL

19
Q

Goal ranges for T2DM

A

hA1c = < 7%
Preprandial = 80-130 mg/dL
Postprandial = <180 mg/dL

20
Q

Describe recombinant human insulin as a treatment form

A

Exogeneous insulin that starts at a baseline dosage and is dependent on the person.

Dosages are changed until the right amount is found for that person to properly control blood sugar levels.

21
Q

Types of recombinant insulin therapy? (delivery methods)

A

Insulin pumps, insulin pens, insulin syringes, and continuous glucose monitors

22
Q

Describe insulin therapy requirements and when they might be increased

A

0.4-1.0
Based on weight mostly
increase if pregnant, illness, and puberty
starting at 0.5
half is prandial (pre/post meal time) and the other half is basal ( long-acting…24 hours)

23
Q

What are the two different types of insulin and give the onset and duration of both

A

rapid-acting insulin (mostly administered via an insulin pump and given in bolus at meal-time) onset is 5-20 minutes and duration is 3-5 hours

Long-acting insulin (basal) has an onset of about an hour and duration of 24 hours.

24
Q

What is the cutoff “safe” blood glucose RPG level for post-prandial?

A

Anything 180 mg/dL or above for prolonged periods of time is what can be detrimental and cause long-term complications (blindness, neurological damage, kidney damage, narrowing of blood vessels, heart complications…)

25
Describe and name the oral medications for blood glucose control mentioned in class
1. Insulin Secretagogues (also called Meglatinides) - stimulate insulin secretion in the presence of glucose and is short-acting. 2. Suffonylurea - stimulates insulin secretion and is more long-acting 3. Biguanides (Metformin)- is the initial medication. It decreases hepatic glucose production and increases muscle uptake of insulin. No extra pancreatic secretion of insulin. Both medications put patient at risk for hypoglycemia...so need to educate on what to do in a situation of hypoglycemia
26
What to do in a state of hypoglycemia?
< 70 mg/dL and responsive then administer 15g of fast-acting carbs such as oral glucose tablets, fruit juice, or sugar candy wait 15 minutes if symptoms (shakiness, clammy hands, sweating, dizziness, fatigue, brain fog, rapid heart-beat) still occur, then do the same until blood sugar is > 70 mg/dL If unresponsive... use a glucose gel or glycogen shot
27
What to avoid when on medications?
Alcohol!
28
Surgery options for control of T2DM
Bariatric surgery Islet cell transplantation
29
What does nutrition assessment, nutrition diagnosis, follow-up, and treatment look like?
Assessment should look at dietary intake, lifestyle, and blood glucose panels and other blood panel like lipid panels. Nutrition diagnosis should focus on intake. (excessive, inadequate, etc) Intervention = nutrient intake is most influential, lifestyle factors, carbohydrate counting (45%), and nutrition intervention follow up every or every-other month and MNT needs are decided by the RDN
30
When should the patient receive insulin?
Blood glucose of >300 mg/dL or hA1c of >10%
31
When is insulin started in the hospital?
at > 140 mg/dL
32
Benefits of exercise
improved glycemic control, blood lipids, and blood pressure reduced risk for t2DM reduced risk for CVD
33
Complications of exercise?
For people on secretagogues such as Suffonylurea... if exercise is >1 hour then there is a risk for hypoglycemia and also for 24 hours after long strenuous exercise So...eat a snack every 30-60 minutes If blood glucose is < 100 mg/dL then extra carbs before working out is needed How to fix? decrease insulin or eat more snacks and make sure to monitor glucose before, during, and after exercise.
34
What is the term for hyperglycemia around 5 am-9 am?
Dawn phenomenon from hormones that deal with circadian rhythm.
35
What are the counter-regulatory hormones that could cause hyperglycemia/dawn phenomenon?
Glucagon Cortisol Epinephrine (adrenaline) Growth hormone Norepinephrine
36
What does HHS stand for and explain it
Hyperglycemic Hyperosmolar (non-ketotic) Syndrome when blood glucose levels are >600 mg/dL and occurs over a period of time but no acidosis Due to counterregulatory hormones More deadly than DKA Polydipsia and Polyurea
37
Nutrition Diagnosis for acute illnesses from DM
inadequate fluid intake, altered nutrition-related laboratory values, or self-monitoring deficit Patients need to stay on track with carbohydrate intake (carbohydrates that are fast acting and tolerable) consistent with insulin
38
Long-term DM Macrovascular complications
Dyslipidemia CVD HTN Damage to blood vessels
39
Microvascular DM Complications
Nephropathy Retinopathy Neuropathy Gastroparesis
40
Common causes of hypoglycemia
- inadequate carbohydrate intake - inconsistent insulin dosages - increased/prolonged physical activity Inadvertent or deliberate errors in insulin doses * Excessive insulin or oral secretagogue medications * Improper timing of insulin in relation to food intake * Intensive insulin therapy * Inadequate food intake * Omitted or inadequate meals or snacks * Unplanned or increased physical activities or exercise * Prolonged duration or increased intensity of exercise * Alcohol intake without food
41
Hypoglycemia clinical manifestations
- Neuroglycopenia (low glucose to brain) * Sweating * Palpitations * Anxiety * Blurred vision * Headache * Slurred speech * Weakness
42
GDM risk factors
obesity history of GDM family history Hispanic
43
Describe the OGTT for GDM
Drink glucose solution, and get blood drawn every 30 minutes for 2 hours
44
GDM Intervention
- Nutrition counseling * MNT should be individualized with focus on energy and nutrient needs for pregnancy * Insulin therapy is preferred to ensure glycemic control * Oral meds are not recommended