Diabetes Drugs

Question 1

Mechanism of action of Metformin?

Answer 1

Increases insulin sensitivity and decreases glucose production

Question 2

Side effect of Metformin?

Answer 2

GI symptoms

Question 3

MoA of SGLT2 inhibitor and example?

Answer 3

Eg. dapagliflozin. Blocks protein that normal reabsorbs glucose from urine - causes more urine to be excreted

Question 4

Side effects of SGLT2 inhibitors?

Answer 4

UTIs, diabetic ketoacidosis, weight loss, hypoglycaemia.

GOOD for CVD

Question 5

MoA of sulfonylurea and example?

Answer 5

Eg. gliclazide. Stimulates insulin release.

Question 6

Side effects of sulfonylureas?

Answer 6

Weight gain, hypoglycaemia

Question 7

MoA of pioglitazone?

Answer 7

Increases insulin sensitivity and decreases glucose production

Question 8

Side effects of pioglitazone?

Answer 8

Weight gain and heart failure

Question 9

MoA and example of DPP-4 inhibitors?

Answer 9

Inhibit DPP-4 so increase incretin activity. Eg. sitagliptin

Question 10

Side effects of DPP-4 Inhibitors?

Answer 10

Headaches