Diabetes and obesity Flashcards
Name the main source of energy for the brain
Glucose
What can the brain use instead of glucose
Ketones
How much glucose does the brain use
80mg glucose/ minute
How much glucose do tissues other than the brain use
50mg glucose/ minute at rest
Can glucose diffuse accorsi cll membranes
no
How is glucose transported if it can’t diffuse across cell membranes
Transported via the GLUT transported
Describe theGLUT transporters
They are uniporters
they work by providing facilitated transport across cell membranes
Name soem different types of GLUT transporters
- glut 3
2. GLUT 4
Describe GLUT 3
It is NOT insulin dependent
Present in Neuronal cells
Describe GLUT 4
It is insulin dependent
Present in muscle and fat cells
What are ketones synthesised from
Fatty acids
What is the co transporter for glucose
Sodium
How are ketones transported
They can simply diffuse across the blood brain barrier
Describe how blood glucose is maintained after meal
- Eating increases blood glucose
2. Insulin stores the glucose as glycogen
How Is glycogen broken down at rest between meals
Glucagon breaks down glycogen
How Is glycogen broken down under stress
Cortisol and adrenal are related to mobilise stored glycogen
Insulin is the _________ pathway
Anabolic
Glucagon, cortisol, adrenaline are the _________ pathway
Catabolic
Name the key organ In charge of maintain blood glucose between meals
Liver
Describe glycogen
It is a polysaccharide of glucose
Where is glycogen found
- LIVER
2. muscles
Can muscle glycogen be mobilised into the blood stream
NO it is for muscle use only
What is the break down of glucose called
Glycolysis
What is the building of glucose called
Gluconeogenesis
Name a common disease affecting glucose maintenance
Diabetes mellitus
What is diabetes mellitus
A group of disorders with many caused which are characterised by a persistently raised blood glucose level
What is diabetes mellitus a result of
- A lack of insulin
- An inability to respond to insulin
(can be both)
Name the different types of diabetes
- Type 1 diabetes mellitus
- Type 2 diabetes mellitus
- Gestational diabetes
- Other
Give examples of other types of diabetes mellitus
- Monogenic diabetes
- Diabetes secondary to pathological conditional such a as trauma or pancreatic surgery
- Drug induced
What is monogenic diabetes
Single gene defect or associated with genetic condition like Down syndrome or turners
Which drugs can lead to drug induced diabetes
long-term corticosteroid treatment
What does type 1 diabetes result in
An absolute insulin deficiency due to destriction of the beta islet cells in the pancreas
What causes beta islet cell destruction
Usually auto immune so T cells mediated destruction of the beta cells in the islets of Langherhans in the pancreas
Where are the beta islets cells found
In the pancreas
What type of function does the pancreas have
Both endocrine and exocrine
When does type 1 diabetes manifest
Usually at 90% destruction of the beta cells
Is diabetes type 1 fatal
Yes if patient doesn’t receive replacement insulin
What are some of the clinical signs that a patient may have type 1 diabetes
- Polyuria
- Polydipsia
- Weight loss (despite an increase in appetite)
- Fatigue
What is polyuria
Excess urination
Why is polyuria dangerous
Glucose in the urine causes osmoticdiuresis as urine osmotic pressure increases so kidneys cant retain the water and the patient becomes fluid depleted
What is polydipsia caused by
Fluid depltion
What is polydipsia
Extreme thirst
Why might a patient with type 1 diabetes lose weight without trying
As insulin isn’t present to do the anabolic pathway so the catabolic pathways are used to generate energy and they use fat sources
What can type 1 diabetics develop if their diabetes isnt controlled
Diabetic ketoacidosis (DKA)
What is Diabetic ketoacidosis (DKA)
Increased production of ketones which are acidic, high levels accumulate so metabolic acidosis leads to a fall in blood pH
Is Diabetic ketoacidosis (DKA) serious
YES it is a medical emergency with a 5-10% mortality
How do we monitor any type of diabetes
Monitor HbA1c blood test every 3 months to check glycated haemoglobin
What is the idea level of HbA1c
Ideally below 48mmol/mol or 6.5%
What is Diabetic ketoacidosis (DKA)
It is a complication of type 1 diabetes mellitus
Describe the presentation of Diabetic ketoacidosis (DKA)
- Rapid deterioration
- Confusion
- Nausea, vomiting
- Abdominal pain and shaking
- Diminshed consciousness in later stages
When is Diabetic ketoacidosis (DKA) more likely to happen
- Infection
- Missed insulin dose
- Surgery
- Binge drinking
What should you advise people with type one diabetes if you carry treatment on them
Make sure you tell patients that they still need to take their insulin and check their Especiallyif you have provided an intervention whereby they may not be able to eat or want to eat.
What is type 2 diabetes mellitus
It is a complex metabolic characterised by varying degrees to insulin resistance
What causes type 2 diabetes mellitus
dysfunction of beta cells in pancreas
Does DKA happen to patients with type 2 diabetes
NO they get Hyperosmolar hyperglycemic syndrome (HHS)