Diabetes Flashcards
> 65 years old have diabetes
~25% of people
> 65 years old have prediabetes
~50% of people
Diabetes Increased risk of geriatric syndromes
Polypharmacy • Cognitive impairment • Depression • Urinary Incontinence • Falls and Pain
Diabetes Diagnostic Criteria 2021 ADA
A1C>6.5% or 8hr FPG >126mg/dL, 2hr plasma glucose >200mg/dL, Random plasma glucose >200mg/dL
A1C correlation
5= 97 mg/dL
6= 126
7= 154
8=183
Glycemic Goals Healthy Older Adult
A1C <7-7.5% (7-7.5%)
Complex/intermediate (multiple chronic illness, ADL impairment or mild-moderate cognitive impairment)
A1C <8% (90-150)
Poor Health (end stage chronic illness)
avoid hypoglycemia
End of life
comfort, avoid hypoglycemia or symptomatic hyperglycemia
Time to benefit of low A1C
benefit of A1C 7 or less declines after 9 years, if life expectancy is short, tight control has no benefit
Blood Glucose Monitoring • Basal insulin or oral agents
Insufficient evidence
• Varies by patient, but consider in: suspected or frequent hypoglycemia, prior
to exercise or critical tasks
Blood Glucose Monitoring • Intensive insulin
• Fasting, prior to meals/snacks, bedtime, occasionally post-prandial,
hypoglycemia suspected; also consider prior to exercise or other critical tasks
• At least 3 times daily, may require 6-10 times per day
Continuous Glucose Monitoring (CGM) Real-Time CGM (rtCGM)
• Most data from RCTs • Continuous reporting, alarms for excursions • Calibrate BID with fingersticks • Newest Dexcom G6 does not require • Reduced time in hypoglycemia rtCGM > isCMG
Continuous Glucose Monitoring (CGM)
• Reports only on demand (swiped by a reader or smart phone) • No fingerstick calibration needed • Does not have alarms for excursions • FreeStyle Libre 2 has real time alarms for high or low glucose levels • Must be scanned at least every 8 hours to avoid gaps in glucose trends
Continuous Glucose Monitoring (CGM) benefits and coverage
Best A1C ↓ if high baseline
• NOT shown to reduce hypoglycemia in T2DM
• May ↓ nocturnal hypoglycemia (rtCGM)
• MAY ↑ satisfaction, time in range
• Medicare covers Dexcom G6 and FreeStyle Libre 2 for T1D/T2D
• Prescribed insulin four times daily
• Checking blood glucose four times daily
Lifestyle and Psychosocial Care for diabetes
Aerobic activity • ~30 min/day most days of the week • No more than 2 days between exercise sessions • Resistance training • 2-3 sessions per week • Flexibility and balance exercises particularly important for > 65 years Optimal nutrition and protein intake • Diabetes is an independent risk factor for frailty • Referral to psychology or counselor if concerns with emotional health
Diabetes Medication Therapy in Older Adults
- Medication classes with low risk of hypoglycemia are preferred
- Avoid overtreatment of diabetes
- Simplify complex regimens
Entry A1C <9%
start monotherapy Metformin
Entry A1C >9% <10%
Dual or Triple Therapy
Entry A1C >10%
Combination injectable
Metformin+Lifestyle+atherosclerotic cardiovascular disease (ASCVD)
Metformin+ Agent with
proven CVD benefit
1. GLP-1 RA (dulaglutide, liraglutide, semaglutide (inj only)) or
2. SGLT2i (canagliflozin, empagliflozin, dapagliflozin)
Metformin+Lifestyle+HF (LVEF <45%)
Metformin+SGLT2i with proven benefit (canagliflozin, empagliflozin, dapagliflozin)
Metformin+Lifestyle+CKD
Preferred: Metformin+ SGLT2i
(canagliflozin, empagliflozin, apagliflozin)
or
Metformin+GLP-1 RA (dulaglutide, liraglutide, semaglutide (inj only);
Metformin+Lifestyle+ minimize hypoglycemia
DPP-4i
GLP-1 RA
SGLT2i
TZD
Metformin+Lifestyle+ minimize weight gain or increase weight loss
GLP-1 RA
or
SGLT2i
Metformin+Lifestyle+ low cost
TZD pioglitazone
or
SU (Glyburide, Glipizide, Glimepiride)
Diabetic medication combinations to avoid
- GLP-1 RAs with DPP4-I
* SUs with insulin
Oral diabetic med with BBW for HF
pioglitazone
Vitamin deficiency caused by Metformin
B12
SU 2nd gen adverse affects
Hypoglycemia increased in older adults • Weight gain • Glyburide contraindicated in older adults
Preferred SU in older adults
Glipizide is preferred SU
Pioglitazone: favorable CVD profile
• Insulin sensitization
• ↓TG, ↑HDL, ↓atherogenic LDL
• ↓ Blood pressure
• ↓ Inflammatory markers and pro- coagulant factors
PROACTIVE: Reduced risk of MACE (major adverse cardiac events) in
T2DM with existing CVD
• IRIS: Reduced CV events in insulin- resistant non-diabetics with recent
cerebrovascular event
• TOSCA-IT: Did NOT reduce CV
outcomes in SU-treated, T2DM
without ASCVD
• Decreases risk of restenosis after stent
placement
Which GLP-1 RA have benefit in ASCVD
Neutral: lixisenatide
Benefit: liraglutide, semaglutideᶧ
(Inj), dulaglutide
Which DPP-4i is NOT recommended with CHF
Potential Risk: saxagliptin
Which GLP-1 RA is beneficial in CKD
Benefit: liraglutide
Renal dosing for GLP-1RA
• Exenatide: NR eGFR < 30
• Lixisenatide: caution when eGFR < 30
• Increased risk of SE in patients with renal
impairment