diabetes Flashcards

1
Q

diabetes mellitus

A
  • chronic disease w/ deficit glucose metabolism
  • normal range:60-100 & serum glucose is 70-110; BS above 200 is diabetic
  • s/s polyuria (increase urine) polydipsia (increase thirst) polyphagia (increase hunger)
  • fasting: 126 twice-diabetic
  • random: 200 twice-diabetic
  • balance of glucagon & insulin
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2
Q

insulin

A
  • commercially prepared insulin: beef, pork and human (less allergic)
  • 90% of time human
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3
Q

admin of insulin

A
  • insulin syringes must be used for accuracy
  • reg insulin-ONLY insulin admin IV
  • reg insulin for sliding scrale coverage
  • roll don’t shake insulin
  • cannot be admin orally
  • site and depth injection will affect absorption
  • exercise decreases the need for insulin; stress, fever or infection increase the need
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4
Q

rotation of sites

A
  • rotation of sites to avoid lepodystrophy; (apathy of tissue); develop site rotation pattern (ADA)
  • lipodystrophy: tissue atrophy or hypertrophy; can interfere w/absorption
  • lipohypertrophy: raised bump for know on skin surface because of injection is same site
  • lipoatrophy: a depression under the skin surface; frequent cause is animal insulin
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5
Q

types of insulin

A
  • rapid acting insulin
  • short acting insulin
  • intermediate acting insulin
  • long acting insulin
  • combinations
  • when drawing up NPH & reg in same syringe draw up regular first
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6
Q

rapid acting insulin

A
  • Ex. lispro, humalog, novolog
  • always clear, no additives that prolong the duration of activity
  • onset 5-30 minutes
  • peak 30 minutes to 1 hr
  • duration: 3-5 hrs
  • do not give Humolog or Lispro any sooner that 5 min. before eating
  • sq
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7
Q

short acting insulin

A
  • Ex. humulin R. novolin R
  • always clear, no additives that prolong the duration of activity
  • onset of action 30 min to 1 hr
  • peak is 2-4 hrs
  • duration is 6-8 hrs
  • given 30 AC(before meals)
  • only insulin given IV
  • can be given sq
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8
Q

intermediate acting insulin

A
  • Ex. NPH, Humulin N, Lente
  • contains a protein (protomine) that prolongs the action
  • onset: 1-2 hrs
  • peak 6-12 hrs
  • duration 18-24 hrs
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9
Q

Lantus

A
  • insulin glargine; long acting
  • onset: 1 hr
  • given daily at bedtime
  • evenly distributed over 24 hrs
  • made from human insulin
  • little chance for hypoglycemia
  • available pen form
  • given alone;no mixing in same syringe
  • no peaks or low
  • works more like the pancreas
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10
Q

Levemir

A
  • long acting insulin
  • peaks: 6-8 hrs & lasts 12-24 hrs
  • made from human insulin
  • available in pen form
  • treats both type 1 & 2
  • sq
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11
Q

Glargine

A
  • long-lasting insulin
  • human insulin
  • treats type 1 & 2 DM
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12
Q

combination insulin(premixed)

A
  • Ex. humulin 70/30, novolin 70/30
  • 70% of dose long lasting
  • 30% of dose short acting
  • contain intermediate & short acting insulin
  • other combos avail
  • avail in pen form
  • easier for pt. to use/no mixing
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13
Q

implications/education

A
  • schedule snacks around peak action time (glucose at lowest)
  • teach regarding admin (rotation of sites, shaking vials, storing vials)
  • teach about foot care, exercise, diet.
  • encourage compliance to prevent the complications of the disease process to the eyes, heart, kidneys.
  • insulin is avail in pump & pen forms.
  • insulin pump: for a person who is on insulin for a long time (cath)
  • teach signs of hypoglycemia
  • rapid acting insulin: make sure they eat
  • snack before bed
  • need to see podiatrist
  • effects peripheral vascular system
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14
Q

insulin storage

A
  • unopened vials in refrigerator
  • once opened it can be kept unrefrigeration for 1 month or in fridge for 3 months
  • do not freeze or put in sun
  • inject insulin at room temp
  • opened vials should not be used for more than 3 months
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15
Q

insulin reactions

A

*hypoglycemia: when more insulin is admin than is needed; can kill someone;low bp, tacycardia, seizures, pt can go into coma; run marathon-decrease insulin

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16
Q

clinical manifestations

A
  • hunger/nausea
  • anxiety/headache/inability to concentrate
  • pale/cool skin
  • shakiness, irritability
  • hypotension/rapid pulse
  • decreasing LOC/seizures/coma
17
Q

treatment for hypoglycemia

A

*Hypoglycemic agents: glucagon, D50 sol
*action: stimulate glucose synthesis to raise the glucose level and provide immediate glucose for use
*use: severe hypoglycemic state
*s/e hyperglycemia (3 P’s), n/v, coma
*milk better than oj
keep monitoring pt. for hypoglycemia

18
Q

insulin reactions(implications)hyperglycemic agents

A
  • consciousness should return within 15-20 min after initial dose; mr dose w/dextrose 50% by iv route
  • glucagon will raise blood sugar levels 5-20 min after admin
  • pts who do not LOC; offer soda instead instead of or in addition toglucon
19
Q

oral antidiabetics (hypoglycemic)drugolbuts

A

sulfonylureas; lowers bs by stimulating the beta cells in the pancreas to release insulin
*1st generation: tells beta cells to produce more insulin; long half-life; short: tolbutamide(orinase); intermediate-acetphexamide (Dymelor); long-chlorpropamide (Diabinese)
2nd generation: shorter half-life; safer to use;tells beta cells to produce more insulin
S/E hypoglycemia (same as insulin)

20
Q

oral antidiabetics

A

Nonsulfonylureas: effect the hepatic and GI production of glucose

21
Q

oral antidiabetic types

A
  • metformin (glucophage) usually first pill; risk of lactic acidosis if given x ray dye;stop 48-72 hrs before test; liver and kidney function normal
  • acarbose (precose) works in stomach
  • miglitol (glyset)
  • rosiglitazone(avandia)
  • rapaglinide (prandin)
  • nateglinide (starfix)very popular
22
Q

oral antidiabetics

A
  • januvia (pill) less hypoglycemia
  • 1-2/day
  • an incretin modifier: increases the level of the incretin hormone so that insulin secretion is increased and glucogan production is decreased
  • reduces FBS & post prandial levels
23
Q

other hormonal drugs

A

*glucocortoroids used to treat inflammatory, allergic & debilitating diseases & conditons
SEVERAL ROUTES: IV, PO, IM & TOPICAL
*dosage needs to be tapered given iv or po routes
*ex. hydrocortisone, decadron, florinef
*po & iv forms may raise BS & cause moon face & weight gain, muscle wasting & euphoria
*do not stop them cold turkey
*steroids will increase blood sugar
*affects healing
*mood swings
* osteoporosis

24
Q

drugs treat thyroid

A
  • hypothyroidism:
    ex. synthroid: increase T3 & T4
  • watch levels
  • hyperthyroidism: ex. PTU; tapazole-reduce the excess secretion of thyroid hormone

*both drugs have many drug interactions: coumadin, dilantin, digoxin