CNS DEPRESSANTS, PSYCHOTROPICS, NARCOTICS/NON NARCOTICS Flashcards
CNS DEPRESSANTS/SEDATIVE/HYPNOTIC
- SEDATIVE: AN AGENT THAT PRODUCES A STATE OF CALMNESS WHEN GIVES IN DIVIDED DOSES. DOES NOT AFFECT LOC
- HYPNOTIC:AN AGENT GIVEN AT BEDTIME TO INDUCE SLEEP, USUALLY IN A LARGER DOSE THAN A SEDATIVE.
- DRUG TOLERANCE & DEPENDENCE
- USED FOR SLEEP: SHORT ACTING-ALLOW PTS TO WAKE UP EARLY IN THE MORNING.
- DO NOT ABRUPTLY WITHDRAW
- TYPES: BARBITUATES, BENZODIAZEPINES
CNS DEPRESSANTS/BARBITUATES
- PHENOBARBITAL, SECONBARBITAL
- USED FOR INTERRUPTED SLEEP, PREOP, ANTICONVULSANT AGENT
- MAJOR S/E: EXCESSIVE CNS DEPRESSION INCLUDING DROWSINESS, HANGOVER; RESTLESSNESS, DELIRIUM; REBOUND INSOMNIA, RESPIRATORY DEPRESSION
- IMPLICATIONS/EDUCATION: HOLD IF RR LESS THAT 10; NOT FOR CHRONIC USE
- OVERDOSE IS TREATED W/ROMAZICON
CNS DEPRESSANT/BENZODIAZEPINES
- USED FOR INSOMNIA, SLEEP INDUCTION; SCHEDULE IV DRUGS
- INCREASE THE ACTION OF GABA TO GABA RECEPTORS
- HAVE SEDATIVE, HYPNOTIC & ANTICONVULSANT PROPERTIES
- MAJOR S/E: CNS CHANGES=DROWSINESS, SLURRED SPEECH, MEMORY IMPAIRMENT, RESP DEPRESSION, HYPOTENSION
- IMPLICATIONS/EDUCATION: SAFETY MEASURES
- TYPES: FLORAZEPAM (DELMANE);TEMAZAPAM CHLORDIAZEPOXIDE (LIBRIUM)
SLEEPING MEDICATION
- NON BENZODIAZEPINES
- HELP TO FALL ASLEEP
- AMBIEN: S/E OLDER PTS SLEEPWALK; SMALL DOSES
- LUNESTA
STIMULANTS
- AMPHETAMINES
- USED TO TREAT NARCOLEPSY, ADHD
- EX. PROVIGIL
PSYCHOTROPICS
- ANTIPSYCHOTIC AGENTS (NEUROLEPTICS)
- ANTIANXIETY
- ANTIDEPRESSANTS
ANTIPSYCHOTICS
- CHLORPROMAZINE (THORAZINE); PROCHLOPERAZINE (COMPAZINE); HALOPERIDOL (HALDOL)
- USED FOR PSYCHIATRIC DISORDERS; ANTIEMETIC
- ACT BY BLOCKING d2 DOPAMINE IN THE BRAIN
- CONTROLS SYMPTOMS/NOT CURE
- NEUROLEPTICS (ANTIPSYCHOTICS)
- THORAZINE: FIRST ANTIPSYCHOTIC
SAFETY MEASURES/ANTIPSYCHOTICS
- EPS SYMPTOMS ARE MAJOR S/E
- STOOPED POSTURE, MASKLIKE FACE, TREMORS AT REST, SHUFFLING GAIT, PILL ROLLING
- MAY GIVE ANTICHOLINERGICS TO PREVENT SOME SYMPTOMS
- TARDIVE DYSKINESIA: SERIOUS-HAPPENS WHEN ANTIPSYCHOTICS ARE USE FOR OVER A YEAR - NOT REVERSABLE-PROTRUDING TONGUE, SMACKING OF LIPS, INVOLUNTARY MOVEMENTS
- PHOTOSENSITIVITY
- EX. CALDOL
ATYPICAL ANTIPSYCHOTICS
- EX. SEROQUEL, RESPERIDOL
* CAUSE LESS EPS SYMPTOMS BUT MAY CAUSE SEDATION
ANTIANXIETY MEDICATIONS
- DIAZEPAM (VALIUM), ALPRAZOLAM (XANAX)
- USED FOR ANXIETY, MUSCLE RELAXANT, PREOP
- DEPRESS THE CNS & INDUCE RELAXATION & THEY INCREASE NEUROTRANSMITTER CONCENTRATION LEVELS OF NOREPINEPHRINE & SEROTONIN
- MAJOR S/E: ABUSE, RESP. DEPRESSION, HYPOTENSION, DEPENDANCE, TOLERANCE,SEDATION
- IMPLICATIONS/EDUCATION: SAFETY MEASURES, AGENTS TREAT SYMPTOMS/DOES NOT CURE ANXIETY
- TREATS OCD, POST TRAMATIC STRESS DISORDER,
- TELLS THE BRAIN TO RELAX
PSYCHOTROPICS
- ANTIDEPRESSANTS: SSRI, TCA, MAOI
- THERE IS NO DIFFERENCE IN EFFICIENCY
- DEPRESSION CRITERIA
- CAUSES OF DEPRESSION
- DRUG SELECTION
- ONSET OF ACTION: SIX WEEKS ARE NEEDED TO EVALUATE ANY ONE DRUG AN ANY ONE DOSAGE
- ARD’S ARE A MAJOR REASON FOR NON-COMPLIANCE
- HERBAL REMEDIES: ST. JOHN’S WART
- SSRI: SAFTER, TAKE UP TO 6 WEEKS TO WORK,DO NOT STOP ABRUPTLY, WEIGHT GAIN, SEXUAL DISFUNCTION
PSYCHOTROPICS/SSRI
*PROZAC, PAXIL, LEXAPRO
*INCREASE THE LEVEL OF SEROTONIN; TREAT OCD & DEPRESSION
*S/E: GI, INSOMNIA, WEIGHT LOSS, HEADACHE, ADR, SEIZURE
*TCA’S AMITRYPTILINE (ELAVIL), IMIPRAMINE ( TOFRANIL)
*BLOCK THE UPTAKE OF NOREPINEPHRINE & SEROTONIN; TREAT DEPRESSION & SOMETIMES CHRONIC HEADACHE
S/E: ANTICHOLINERGIC EFFECTS (S.E. GREATER IN TCA’S THAN IN SSRI); EPS EFFECTS; SEDATION & WEIGHT GAIN
PSYCHOTROPICS/MAOI
- PHENALAZINE SULFATE (NARDIL)
- INACTIVATE NOREPINEPHRINE, DOPAMINE, EPINEPHRINE & SEROTONIN
- USED AS A LAST CHOICE TO TREAT DEPRESSION
- ADR: HYPERTENSIVE CRISIS WHEN TAKEN W/FOODS CONTAINING TYRAMINE(AGED CHEESE, WINE, BEER, AVACADOS, BANANAS, YOGURT, PEPPERONI
- S/E: CNS STIMULATION; ORTHOSTATIC HYPOTENSION, INSOMNIA AND ANTICHOLINERGI EFFECTS
- MANY FOOD AND DRUG INTERACTIONS
ATYPICAL ANTIDEPRESSANTS
- SIMILAR TO SSRI; BLOCK SEROTONIN REUPTAKE BUT HAVE LESS SIDE EFFECTS
*USED TO TREAT DEPRESSION, ANXIETY AND SMOKING
*EX. BUPROPION (WILLBUTRIN, ZYBAN)
S/E: HEADACHE, DROWSINESS, DECREASED BP; SEIZURES
MOOD STABILIZERS
- LITHIUM, TEGRETOL
- MUST CHECK RENAL FUNCTION
- MUST MONITOR DRUG LEVELS
- HIGH LEVELS ARE LIFE THREATENING
- LITHIUM TOXICITY: AFFECTS HEART