Diabetes Flashcards
1
Q
How is insulin secreted?
A
0.4 ng/ml is basal []
Rises 5-10 fold when glucose increases.
2
Q
What is the half life of insulin?
A
5 minutes
3
Q
When was T1D first treated?
A
In 1922
Ted Ryder
Islet transplant in 2005.
(Difficult to obtain sufficient pancreas –> only used in very severe cases!)
4
Q
How is central adiposity linked to T2DM?
A
Release of TNF / alpha resistin
Ins resistance
Beta cell dysfunction.!
5
Q
How do alpha-glucosidase inhibitors work?
A
Slow down carb digestion
Less pressure for beta cells to secrete insulin.
6
Q
What is the most common cause of MODY?
A
50-60% have mutations in HNG alpha –> insufficient insulin synthesis.
