diabetes Flashcards
- Polydipsia and polyuria related to diabetes are primarily due to
b. fluid shifts resulting from the osmotic effect of hyperglycemia
Rationale: The osmotic effect of glucose cause the manifestations of polydipsia and polyuria.
- Which statement would be correct for a patient with type 2 diabetes who was admitted to the hospital with pneumonia?
d. The patient may have enough endogenous insulin to prevent ketosis but is at risk for hyperosmolar hyperglycemia syndrome.
Rationale: Hyperosmolar hyperglycemia syndrome (HHS) is a life-threatening syndrome that
can occur in a patient with diabetes who is able to make enough insulin to prevent diabetesrelated ketoacidosis (DKA) but not enough to prevent severe hyperglycemia, osmotic diuresis,
and extracellular fluid depletion.
- Analyze the following diagnostic findings for your patient with type 2 diabetes. Which result will need further assessment?
a. A1C 9%
Rationale: Lowering hemoglobin A1C (to less than 7%) reduces microvascular and neuropathic
complications. Keeping blood glucose levels in a tighter range (normal hemoglobin A1C level,
less than 6%) may further reduce complications but increases hypoglycemia risk.
- Which statement by the patient with type 2 diabetes is accurate?
a. “I will limit my alcohol intake to 1 drink each day.”
Rationale: The guideline for alcohol consumption in men with diabetes is 0-2 drinks per day.
For women with diabetes it is 0-1 drink per day.
- You are caring for a patient with newly diagnosed type 1 diabetes. What information is essential to include in your patient teaching before discharge from the hospital? (select all that apply)
a. Insulin administration
d. Use of a portable blood glucose monitor
e. Hypoglycemia prevention, symptoms, and treatment
Rationale: The nurse ensures that the patient understands the proper use of insulin. The nurse
teaches the patient how to use the portable blood glucose monitor and how to recognize and treat
signs and symptoms of hypoglycemia and hyperglycemia. These are referred to as “survival
skills.”
- What is the priority action for the nurse to take if the patient with type 2 diabetes reports blurred vision and irritability?
d. Check the patient’s blood glucose level.
Rationale: Check blood glucose whenever hypoglycemia is suspected so that immediate action
can be taken if necessary.
- A patient with diabetes has a serum glucose level of 824 mg/dL (45.7 mmol/L) and is unresponsive. After assessing the patient, the nurse suspects diabetes-related ketoacidosis rather than hyperosmolar hyperglycemia syndrome based on the finding of
c. rapid, deep respirations.
Rationale: Signs and symptoms of DKA include manifestations of dehydration, such as poor
skin turgor, dry mucous membranes, tachycardia, and orthostatic hypotension. Early symptoms
may include lethargy and weakness. As the patient becomes severely dehydrated, the skin
becomes dry and loose, and the eyeballs become soft and sunken. Abdominal pain is another symptom of DKA that may be accompanied by anorexia and vomiting. Kussmaul respirations (i.e., rapid, deep breathing associated with dyspnea) are the body’s attempt to reverse metabolic acidosis through the exhalation of excess carbon dioxide. Acetone is identified on the breath as a sweet, fruity odor. Laboratory findings include a blood glucose level greater than 250 mg/dL, arterial blood pH less than 7.30, serum bicarbonate level less than 15 mEq/L, and moderate to high ketone levels in the urine or blood.
- Which are appropriate therapies for patients with diabetes? (select all that apply)
a. Use of statins to reduce CVD risk
c. Use of ACE inhibitors to treat nephropathy
e. Use of laser photocoagulation to treat retinopathy
Rationale: In patients with diabetes who have albuminuria, angiotensin-converting enzyme
(ACE) inhibitors (e.g., lisinopril [Prinivil, Zestril]) or angiotensin II receptor antagonists (ARBs)
(e.g., losartan [Cozaar]) are used. Both classes of drugs are used to treat hypertension and delay
the progression of nephropathy in patients with diabetes. The statin drugs are the most widely
used lipid-lowering agents. Laser photocoagulation therapy is indicated to reduce the risk of
vision loss in patients with proliferative retinopathy, in those with macular edema, and in some
cases of Nonproliferative retinopathy
diabetes mellitus
Diabetes mellitus (DM), most often referred to as diabetes, is a chronic multisystem disease characterized by hyperglycemia from abnormal insulin production, impaired insulin use, or both.
where’s insulin made
Insulin is a hormone made by the β cells in the islets of Langerhans of the pancreas
normal glucose level
normal glucose range of about 74 to 106 mg/dL (4.1 to 5.9 mmol/L).
insulin
Insulin promotes glucose transport from the bloodstream across the cell membrane to the cytoplasm of the cell (Fig. 48.2). Cells break down glucose to make energy. Liver and muscle cells store excess glucose as glycogen. The rise in plasma insulin after a meal inhibits gluconeogenesis, enhances fat deposition of adipose tissue, and increases protein synthesis. For this reason, insulin is an anabolic, or storage, hormone. The fall in insulin level during normal overnight fasting promotes the release of stored glucose from the liver, protein from muscle, and fat from adipose tissue.
type 1
Type 1 diabetes, formerly known as juvenile-onset diabetes or insulin-dependent diabetes mellitus (IDDM), accounts for about 5% to 10% of all people with diabetes. Type 1 diabetes generally affects people under 40 years of age, although it can occur at any age.3
Etiology and Pathophysiology
Type 1 diabetes is an autoimmune disorder in which the body develops antibodies against insulin and/or the pancreatic β cells that make insulin. This eventually results in not enough insulin for a person to survive. A genetic predisposition and exposure to a virus are factors that may contribute to the development of immune-related type 1 diabetes.
onset type 1
In type 1 diabetes, the islet cell autoantibodies responsible for β-cell destruction are present for months to years before the onset of symptoms. Manifestations develop when the person’s pancreas can no longer make enough insulin to maintain normal glucose. Once this occurs, the onset of symptoms is usually rapid. Patients often are initially seen with impending or actual ketoacidosis. The patient usually has a history of recent and sudden weight loss and the classic symptoms of polydipsia (excessive thirst), polyuria (frequent urination), and polyphagia (excessive hunger).
The person with type 1 diabetes requires insulin from an outside source (exogenous insulin) to sustain life. Without insulin, the patient will develop diabetes-related ketoacidosis (DKA), a life-threatening condition resulting in metabolic acidosis. Newly diagnosed patients may have a remission, or “honeymoon period,” for 3 to 12 months after starting treatment. During this time, the patient needs little injected insulin because β-cell insulin production is still sufficient for healthy blood glucose levels. Eventually, as more β cells are destroyed and blood glucose levels increase, the honeymoon period ends and the patient will require insulin on a permanent basis.
type 2
Type 2 diabetes is more prevalent in some ethnic populations. Blacks, Asian Americans, Hispanics, Native Hawaiians or other Pacific Islanders, and Native Americans have a higher rate of type 2 diabetes than whites.2
combination of inadequate insulin secretion and insulin resistance. The pancreas usually makes some endogenous (self-made) insulin. However, the body either does not make enough insulin or does not use it effectively, or both. The presence of endogenous insulin is a major distinction between type 1 and type 2 diabetes. In type 1 diabetes, there is an absence of endogenous insulin.
insulin resistence, type 2
first factor is insulin resistance, a condition in which body tissues do not respond to the action of insulin because insulin receptors are unresponsive, are insufficient in number, or both.
A second factor in the development of type 2 diabetes is a marked decrease in the ability of the pancreas to make insulin, as the β cells become fatigued from the compensatory overproduction of insulin or when β-cell mass is lost.
This leads to a third factor, which is inappropriate glucose production by the liver. Instead of properly regulating the release of glucose in response to blood levels, the liver does so in a haphazard way that does not correspond to the body’s needs at the time.
clinical manifestation type 1
type 1 diabetes is rapid, the first manifestations are usually acute. The classic symptoms are polyuria, polydipsia, and polyphagia. The osmotic effect of excess glucose in the bloodstream causes polydipsia and polyuria. Polyphagia is a result of cellular malnourishment when insulin deficiency prevents cells from using glucose for energy. Weight loss may occur because the body cannot get glucose and instead breaks down fat and protein to try to make energy. Weakness and fatigue may result because body cells lack needed energy from glucose. Ketoacidosis, a complication most common in those with untreated type 1 diabetes, is associated with additional manifestations. It is discussed later in this chapter.
clincal manifestation type 2
The manifestations of type 2 diabetes are often nonspecific. It is possible a person with type 2 diabetes will have classic symptoms associated with type 1 diabetes, including polyuria, polydipsia, and polyphagia. Some of the more common manifestations associated with type 2 diabetes are fatigue, recurrent infections, recurrent vaginal yeast or candida infections, prolonged wound healing, and vision problems.
diagnose diabetes
- A1C of 6.5% or higher
- Fasting plasma glucose (FPG) level of 126 mg/dL (7.0 mmol/L) or greater. Fasting is defined as no caloric intake for at least 8 hours
- A 2-hour plasma glucose level of 200 mg/dL (11.1 mmol/L) or greater during an OGTT, using a glucose load of 75 g
- In a patient with classic symptoms of hyperglycemia (polyuria, polydipsia, unexplained weight loss) or hyperglycemic crisis, a random plasma glucose level of 200 mg/dL (11.1 mmol/L) or greater
diabetes drug therapy
- Insulin (Fig. 48.3 and Tables 48.3 and 48.4)
- OAs and noninsulin injectable agents (Table 48.7)
- Enteric-coated aspirin (81–162 mg/day)
- ACE inhibitors (see Table 32.6)
- Angiotensin II receptor blockers (ARBs) (see Table 32.6)
- Antihyperlipidemic drugs (see Table 33.6)
type 1 long/intermediate acting insulin
Without 24-hour background insulin, people with type 1 diabetes are more prone to developing DKA. Many people with type 2 diabetes who use OAs will need basal insulin to adequately manage blood glucose levels.
intermediate acting
typically cloudy. must roll in hands to disolve
insulin injection site
abdomen, back arms, thighs, buttock
somogi effect
hyperglycemia in the morning.. high dose of insulin given at night decreases glucose at night, stimulates release counterregulatory hormones (glucagon, epi, GH, cortisol) which stimulates lipolysis, gluconeogenesis, and glycogenolysis, which causes rebound hyperglycemia
tx:
snack at night and insulin reduction
dawn phenomenon
hyperglycemia upon waking. GH and cortisol may be the cause.
oral insulin
see
metformin
Drug Alert
Metformin
- Do not use in patients with kidney disease, liver disease, or heart failure. Lactic acidosis is a rare complication of metformin accumulation.
- IV contrast media that contain iodine pose a risk for CIN, which could worsen metformin-induced lactic acidosis.
- To reduce risk for CIN, discontinue metformin 2 days before the procedure.
- May be resumed 48 hours after the procedure, assuming kidney function is normal.
- Do not use in people who drink excess amounts of alcohol.
- Take with food to minimize GI side effects.
nutrition diabetes 1
People with type 1 diabetes base their meal planning on usual food intake and preferences balanced with insulin and exercise patterns. The patient coordinates insulin dosing with eating habits and activity pattern in mind. Day-to-day consistency in timing and amount of food eaten makes it much easier to manage blood glucose levels, especially for those using conventional, fixed insulin regimens. Patients using rapid-acting insulin can adjust the dose before each meal based on the current blood glucose level and the carbohydrate content of the meal. Intensified insulin therapy, such as multiple daily injections or the use of an insulin pump, allows considerable flexibility in food selection and can be adjusted for changes from usual eating and exercise habits. This does not diminish or replace the need for healthy food choices and a well-balanced diet.
nutrition diabetes 2
emphasizes achieving glucose, lipid, and BP goals. Modest weight loss has been associated with improved insulin sensitivity. Therefore weight loss is recommended for all persons with diabetes who are overweight or obese.13
There is no one proven strategy or method. A nutritionally adequate meal plan with appropriate serving sizes, a reduction of saturated and trans fats, and low carbohydrates can decrease calorie consumption. Spacing meals is another strategy that spreads nutrient intake throughout the day. A weight loss of 5% to 7% of body weight often improves blood glucose levels, even if desirable body weight is not achieved. Weight loss is best achieved by a moderate decrease in calories and an increase in caloric expenditure. Regularly exercising and adopting new behaviors and attitudes can promote long-term lifestyle changes. Monitoring blood glucose levels, A1C, lipids, and BP gives feedback on how well the goals of nutrition therapy are being met.
exercise
The ADA recommends that people with diabetes engage in at least 150 min/wk (30 minutes, 5 days/week) of a moderate-intensity aerobic physical activity (Table 48.9). The ADA encourages people with type 2 diabetes to perform resistance training 3 times a week unless contraindicate
glucose monitoring
self-monitoring blood glucose - finger sticks
continuous monitoring - insulin pump and sub q monitor injection
**use rapid acting (lispro) insulin
**programmed to deliver continuous infusion rapid acting for 24hrs a day, known as basal rate
teaching is essential for monitoring