Developmental Pathways in Cancer Flashcards
1
Q
Shh signaling
A
2
Q
Invasion and Metastasis Diagram
A
3
Q
Targeting CSCs
A
Wnt blockade!
4
Q
Vismodegib
A
Smoothened inhibitor. Effective anti-cancer drug for patients with Shh pathway mutations in Shh or in Patched, usually resulting in basal cell carcinoma. Also useful for treating Patched LOF mutations.
WARNING: Teratogen, mandatory pregnancy testing and stringent contraception.
