Developmental Genetics

Question 1

What are the three categories of developmental molecules? (broad)

Answer 1

TF
Signaling moleucles
Receptor molecules

Question 2

What are examples of homeobox containing genes?

Answer 2

Hox
Pax
POU
Lim protein genes
Dlx

Question 3

What do loss of function mutations in homeobox containing genes result in?

Answer 3

Posterior to anterior transformations

Question 4

What do gain of fxn mutations in homeobox containing genes result in?

Answer 4

Anterior to posterior transformation

Question 5

What do T box genes do? (Tbx)

Answer 5

Play role in inducing mesodermal germ layer and coordinating outgrowth of arm or leg

Question 6

What do helix loop helipx genes do?

Answer 6

Code for basic helix loop helix TF. Important in myogenesis

Question 7

Forkhead (Fox) genes?

Answer 7

Expressed in developing organs throughout body. Type of helix loop helix family

Question 8

What are two gene families within the Zince finger TF’s?

Answer 8

Sox genes which include SRY gene

Wt1 important for development of embryonic kidney and adult kidney

Question 9

Where does WT1 and Wnt get their name from?

Answer 9

Wilms tumor which is a kidney tumor that develops in kids