Developmental Flashcards
How many neurons does the adult brain comprise?
The adult brain comprises of 80 billion neurons.
At what rate are neurons added during early embryonic life?
Neurons are added at a rate of 250,000 neurons/min.
What percentage of adult brain size is achieved by 2 years after birth?
Growth at 2 years after birth is 80% of the adult size.
How many other cells does a single neuron interact with on average?
A single neuron interacts with an average of 15,000 other cells.
What happens to the brain’s surface area from 5 to 9 months?
The brain at 5 months is quite smooth; by 9 months it starts growing the surface area.
What are the three parts of gastrulation?
Ectoderm, Mesoderm, and Endoderm.
What does the ectoderm develop into?
The ectoderm becomes your CNS, PNS, and skin.
What does the mesoderm develop into?
The mesoderm develops into the skeletal system, muscles, and vascular region.
What does the endoderm develop into?
The endoderm develops into the gut, lungs, and liver.
When does the neural tube start forming?
The neural tube starts forming at 4 weeks.
What does the neural tube form?
The neural tube forms the basis of the brain and spinal cord.
What develops from the rostral front part of the neural tube?
The rostral front part develops into 3 chambers that eventually become the ventricles.
What does the hindbrain form?
The hindbrain forms the cerebellum.
What are the three stages of neurodevelopment?
Neurogenesis, Neural migration, and Neural differentiation.
What happens during neurogenesis?
Progenitor (stem) cells divide by mitosis in the neural tube.
What is the process of neural migration?
Neurons migrate to the outside of the tube, guided by radial glia cells.
What occurs during neural differentiation?
Immature neurons differentiate into different types of specialized neurons.
What is synaptogenesis?
Over-production of synapses, redundancy, beginning from about 17 weeks after conception but mostly postnatal.
What is apoptosis in the context of neurodevelopment?
Clearing of neurons whose axons don’t find their targets, activated by genetic processes.
When does synapse reorganization occur?
Synapse reorganization occurs from 26 weeks until after birth.
What is myelination?
Myelination is produced by glial cells and involves a gradual increase in the myelin sheath surrounding the axons.
What is DNA?
DNA is packed into chromosomes in the nucleus of our cells and contains our genetic information
How many pairs of chromosomes do humans have?
Humans have 23 pairs of chromosomes.
What is a gene?
A gene is an area of DNA which codes RNA.