Development--Sievert Flashcards
Somites give rise to what 2 things?
dermatomyotome & sclerotome
What does sclerotome make?
bone
How do you developmentally form a vertebral body?
the sclerotomal cells migrate around the notochord & neural tube & form the vertebral body.
If vertebral body formation doesn’t work out well, what could you end up w/?
spina bifida
**& bad lamina & spinous process formation
What is spina bifida occulta?
this means that you can’t immediately tell that the child has spina bifida…the spine is just bulging out of the back & susceptible to injury.
What is a meningocele?
some of the meninges of the spinal cord are bulging out
What is a myelomeningocele?
a little more severe, the spinal cord is kind of bulging out the back.
What is Rachischisis?
this is where the neural tube doesn’t fully close
Sclerotomal segments must _____ to make up vertebrae. If this doesn’t happen correctly you could get _______.
fuse
scoliosis
When do the limbs develop?
Early!
Day 24 for the upper limb
Day 28 for the lower limb
What is the sequence for limb development?
rostral –>caudal
upper limb before the lower limb
T/F The developmental process in the formation of limbs is molecularly regulated by proteins. Give examples.
True
Ex:
positioning of the limb, what migrates to the anterior & posterior compartments, where the thumb goes
T/F Congenital defects of the limb are quite common b/c it develops early on in gestation.
False. Even tho they develop early on, defects are NOT common.
T/F Limb development is susceptible to teratogens.
TRUE drugs etc can have a huge effect b/c the limbs are developing in the 4th & 5th week
When congenital defects do occur in the limbs, they are usu associated w/ severe defects. Give examples.
cardiovascular
genitourinary
craniofacial
