development of thyroid gland, tongue, and ear Flashcards
what is the first endocrine gland to develop in the embryo?
thyroid gland
when does thyroid gland development begin?
24 days after fertilization
the thyroid gland develops from a median endodermal thickening in the ___________
floor of a primordial pharynx
thyroid primordium
small outpouching that develops from the thickening in the floor of the primordial pharynx
the thyroid primordium comes from which pharyngeal pouch?
2nd
thyroglossal duct
narrow tube connecting the thyroid gland to the tongue that eventually dissolves
how are the two lobes of the thyroid gland connected?
isthmus of the thyroid gland
-lies anterior to the developing second and third tracheal rings
by what week does the thyroid assume definitive shape and reach its final site in the neck?
seventh week
the thyroglossal duct has normally degenerated by what week?
seventh week
foramen cecum
the proximal opening of the thyroglossal duct that persists
-small pit in tongue
the pyramidal lobe extends upward from the isthmus in about _____% of people
50%
levator of thyroid gland
fibrous tissue or smooth muscle that attaches the pyramidal lobe to the hyoid bone
the pyramidal lobe and associated smooth muscle represent a persistent part of the distal end of the _____
thyroglossal duct
site of origin of thyroglossal duct between floor of branchial arches 1 and 2
foramen cecum
what does the thyroid primordium consist of?
solid mass of endodermal cells
what does the cellular aggregation of the thyroid primordium break up into?
a network of epithelial cords
by what week do the cords divide into small cellular groups?
10
what forms in each cell cluster of the thyroid when the cells become arranged in a single layer?
lumen
what happens during the 11th week in thyroid development?
colloid begins to appear in each cell called thyroid follicles and iodine concentration and synthesis of thyroid hormones can be demonstrated
thyroid secretion reaches adult level by how many weeks?
35 weeks
congenital hypothyroidism (cretinism)
most common metabolic disorder in neonates
-common cause of intellectual disability
causes of congenital hypothyroidism
agenesis–failure of normal development of thyroid gland
ectopic thyroid–situated in a different location (e.g. beneath tongue)
signs and symptoms of congenital hypothyroidism
- retarded physical and mental growth
- spine curved and height is less than 3 ft
- head is large with wiry hair
- thick eyelids and large tongue
- abdomen protruding and sexual maturity not seen
treatment of congenital hypothyroidism
levothyroxine given to children