Development of Mouse Reporting Questions

Question 1

What is DPC? How does it work?

Answer 1

days post coitus; staging by days

Question 2

Presence of what is looked for to indicate start of DPC?

Answer 2

vaginal plug

Question 3

Staging of mouse embryo development based one external/internal morphological changes of the embryo that may not be dependent on the age or size of mosue

Answer 3

Theiler

Question 4

How many TS stages?

Answer 4

26

Question 5

Why is mouse not good model organism?

Answer 5

Not exactly human
In utero development
Comparatively large genome; there are organisms with more compact genomes
Long gestation period compared to other model organisms
Endocrinological, physiological, and environment influences cell function
Large storage areas needed

Question 6

How to improve Theiler staging?

Answer 6

In vitro dev’t
putting camera
Differentail gene expression analysis

Question 7

Why is mouse good model organism (5 lang siguro)

Answer 7

Small mammal. It's a mammal.
Short gestation period
Enter puberty relatively early
Large litter size
Long reproductive lifespan
Males do not harm pups
Easy to handle
Pregnancies are easily timed from insemination
Placentation and early development are similar to humans
Widely studied genetics